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Gene: Birc5 (baculoviral IAP repeat-containing 5) Rattus norvegicus
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Symbol: Birc5
Name: baculoviral IAP repeat-containing 5
Description: Predicted to have several functions, including chaperone binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and protein dimerization activity. Involved in several processes, including cellular response to ethanol; cellular response to stem cell factor stimulus; and response to glucocorticoid. Localizes to the apical plasma membrane; cytoplasm; and nucleus. Used to study endometriosis and pulmonary hypertension. Biomarker of acute pancreatitis; artery disease (multiple); congestive heart failure; malignant glioma; and stomach carcinoma. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5); PARTICIPATES IN histone modification pathway; colorectal cancer pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AP14; apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; survivin
Orthologs:
Homo sapiens (human) : BIRC5 (baculoviral IAP repeat containing 5)  HGNC  Alliance
Mus musculus (house mouse) : Birc5 (baculoviral IAP repeat-containing 5)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : BIRC5 (baculoviral IAP repeat containing 5)
Canis lupus familiaris (dog) : BIRC5 (baculoviral IAP repeat containing 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Birc5 (baculoviral IAP repeat containing 5)
Sus scrofa (pig) : BIRC5 (baculoviral IAP repeat containing 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.010106,856,097 - 106,864,419 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010106,494,775 - 106,503,097 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10101,633,441 - 101,641,341 (+)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Birc5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70499
Created: 2002-05-02
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.