Birc5 (baculoviral IAP repeat-containing 5) - Rat Genome Database

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Gene: Birc5 (baculoviral IAP repeat-containing 5) Rattus norvegicus
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Symbol: Birc5
Name: baculoviral IAP repeat-containing 5
RGD ID: 70499
Description: Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein dimerization activity; and small GTPase binding activity. Involved in several processes, including cellular response to ethanol; cellular response to stem cell factor stimulus; and response to glucocorticoid. Located in apical plasma membrane. Used to study endometriosis and pulmonary hypertension. Biomarker of acute pancreatitis (multiple); artery disease (multiple); congestive heart failure; high grade glioma; and stomach carcinoma. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5); PARTICIPATES IN histone modification pathway; colorectal cancer pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AP14; apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; survivin
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,567,369 - 103,580,069 (+)NCBIGRCr8
mRatBN7.210103,072,530 - 103,081,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,073,408 - 103,081,380 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,174,435 - 108,182,841 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,637,549 - 107,645,954 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010102,994,242 - 103,002,165 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,856,097 - 106,864,419 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,856,097 - 106,864,413 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,494,775 - 106,503,097 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10101,633,441 - 101,641,341 (+)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute megakaryocytic leukemia  (ISO)
acute necrotizing pancreatitis  (IEP)
acute pancreatitis  (IEP)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
adrenocortical carcinoma  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
bladder urothelial carcinoma  (ISO)
brain glioma  (ISO)
Brain Injuries  (IEP)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
chromophobe renal cell carcinoma  (ISO)
chronic myeloid leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (IEP)
COVID-19  (ISO)
ductal carcinoma in situ  (ISO)
endometrial hyperplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (IMP)
Experimental Liver Cirrhosis  (IEP)
Experimental Liver Neoplasms  (IEP)
genetic disease  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (IEP)
Kidney Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant pleural mesothelioma  (ISO)
Mesothelioma  (ISO)
myocardial infarction  (IEP)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic adenocarcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IEP,IMP)
Refractory Anemia  (ISO)
Refractory Anemia with Excess of Blasts  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP,IMP)
small cell carcinoma  (ISO)
squamous cell carcinoma  (ISO)
stomach carcinoma  (IEP)
Stomach Neoplasms  (ISO)
Testicular Germ Cell Tumor  (ISO)
thymoma  (ISO)
thyroid gland carcinoma  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(-)-noscapine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-monopalmitoylglycerol  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-diaminotoluene  (ISO)
2,4-Dihydroxychalcone  (ISO)
2-acetamidofluorene  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alvocidib  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
Antrocin  (ISO)
aprepitant  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
ATP  (ISO)
atrazine  (ISO)
azadirachtin A  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
barium sulfate  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoic acid  (ISO)
Berbamine  (ISO)
berberine  (ISO)
beta-naphthoflavone  (EXP)
betulin  (ISO)
betulinic acid  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
budesonide  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capillarisin  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
ceric oxide  (EXP)
chlorambucil  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chrysazin  (ISO)
chrysene  (ISO)
ciclopirox  (ISO)
ciglitazone  (ISO)
Cinobufagin  (ISO)
Cirsimarin  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
coumarins  (ISO)
coumestrol  (ISO)
crizotinib  (ISO)
crocin-1  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
dacarbazine  (ISO)
dactolisib  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
Destruxin B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazene  (ISO)
diazinon  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
digitoxin  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioscin  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (ISO)
epoxomicin  (ISO)
erlotinib hydrochloride  (ISO)
etacrynic acid  (ISO)
ethanol  (ISO)
etodolac  (ISO)
etoposide  (ISO)
everolimus  (ISO)
Evodiamine  (ISO)
fangchinoline  (ISO)
farnesyl diphosphate  (ISO)
fenhexamid  (ISO)
fenpyroximate  (ISO)
fisetin  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
fucoidan  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP,ISO)
furosemide  (EXP)
gamma-aminobutyric acid  (EXP)
gamma-tocopherol  (ISO)
gedunin  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
gingerol  (ISO)
glycochenodeoxycholic acid  (EXP)
gossypol  (ISO)
guggulsterone  (ISO)
Hexamethonium  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
inuviscolide  (ISO)
irinotecan  (ISO)
isoflurane  (EXP)
isotretinoin  (ISO)
Jatrorrhizine  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
lapatinib  (ISO)
LCL161  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
leptomycin B  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
lithium atom  (EXP)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP)
lonafarnib  (ISO)
lovastatin  (ISO)
lucanthone  (ISO)
LY294002  (EXP,ISO)
magnesium oxide  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
melatonin  (ISO)
melphalan  (ISO)
memantine  (ISO)
menadione  (ISO)
menaquinone  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methoxsalen  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
monocrotaline  (EXP)
monodansylcadaverine  (ISO)
morin  (ISO)
motexafin gadolinium  (ISO)
Myrtucommulone A  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
navitoclax  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel ferrite  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nimodipine  (ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
nocodazole  (ISO)
o-anisidine  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oridonin  (ISO)
osimertinib  (ISO)
osthole  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
palmatine  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
PD173074  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
picropodophyllotoxin  (ISO)
pifithrin-?  (ISO)
pinosylvin  (ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
potassium iodide  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prodigiosin  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
prostaglandin E2  (ISO)
puerarin  (ISO)
pyrethrins  (ISO)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
ritonavir  (ISO)
romidepsin  (ISO)
rotenone  (EXP,ISO)
ruxolitinib  (ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sepantronium  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sorafenib  (ISO)
stattic  (ISO)
staurosporine  (ISO)
sulfadimethoxine  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
syringin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
terameprocol  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
Tomentosin  (ISO)
topotecan  (EXP,ISO)
trans-pinosylvin  (ISO)
triadimefon  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
tyrphostin B42  (ISO)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
venetoclax  (ISO)
verteporfin  (ISO)
vinyl carbamate  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Myocardial expression of survivin, an apoptosis inhibitor, in aging and heart failure. An experimental study in the spontaneously hypertensive rat. Abbate A, etal., Int J Cardiol. 2006 Aug 28;111(3):371-6. Epub 2005 Oct 27.
2. Autoantibodies to survivin in the sera of patients with infiltrating ductal carcinoma of the breast. Al-Joudi FS and Iskandar ZA, Med J Malaysia. 2006 Aug;61(3):302-6.
3. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Ambrosini G, etal., Nat Med 1997 Aug;3(8):917-21.
4. The prognostic significance of COX-2 and survivin expression in ovarian cancer. Athanassiadou P, etal., Pathol Res Pract. 2008;204(4):241-9. Epub 2008 Jan 2.
5. Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence. Barnes N, etal., Br J Cancer. 2006 Jan 30;94(2):253-8.
6. Altered Cytoplasmic-to-Nuclear Ratio of Survivin Is a Prognostic Indicator in Breast Cancer. Brennan DJ, etal., Clin Cancer Res. 2008 May 1;14(9):2681-9.
7. Expression of inhibitor of apoptosis family proteins in human oral squamous cell carcinogenesis. Chen YK, etal., Head Neck. 2011 Jul;33(7):985-98. doi: 10.1002/hed.21582. Epub 2010 Oct 21.
8. NSAIDs enhance proteasomic degradation of survivin, a mechanism of gastric epithelial cell injury and apoptosis. Chiou SK and Mandayam S, Biochem Pharmacol. 2007 Nov 15;74(10):1485-95. Epub 2007 Jul 22.
9. Death receptor 5 (DR5) and a 5-gene apoptotic biomarker panel with significant differential diagnostic potential in colorectal cancer. Devetzi M, etal., Sci Rep. 2016 Nov 9;6:36532. doi: 10.1038/srep36532.
10. Expression of survivin, PTEN and p27 in normal, hyperplastic, and carcinomatous endometrium. Erkanli S, etal., Int J Gynecol Cancer. 2006 May-Jun;16(3):1412-8.
11. Zhonghua zhong liu za zhi [Chinese journal of oncology] Feng ZB, etal., Zhonghua Zhong Liu Za Zhi. 2007 Sep;29(9):662-5.
12. Angiogenic signal triggered by ischemic stress induces myocardial repair in rat during chronic infarction. Fukuda S, etal., J Mol Cell Cardiol. 2004 Apr;36(4):547-59.
13. Transcriptional expression of survivin and its splice variants in cervical carcinomas. Futakuchi H, etal., Int J Gynecol Cancer. 2007 Sep-Oct;17(5):1092-8.
14. Prostate-derived Ets transcription factor as a favorable prognostic marker in ovarian cancer patients. Ghadersohi A, etal., Int J Cancer. 2008 Sep 15;123(6):1376-84.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Expression patterns of inhibitor of apoptosis proteins in malignant pleural mesothelioma. Gordon GJ, etal., J Pathol. 2007 Mar;211(4):447-54. doi: 10.1002/path.2121.
17. Gene Data File Integration of LocusLink data, October 12, 2001
18. Expression of survivin in fetal and adult normal tissues of rat. Iskandar ZA and Al-Joudi FS, Malays J Pathol. 2006 Dec;28(2):101-5.
19. Expression of human telomerase reverse transcriptase and survivin gene in patients with myelodysplastic syndrome Jiao XL, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Apr;16(2):294-8.
20. Detection of autoantibodies to survivin in cervical mucus from patients with human papillomavirus-associated cervical cancer and precursor lesions. Jimenez LG, etal., Autoimmunity. 2007 Feb;40(1):66-72.
21. Cell-specific upregulation of survivin after experimental traumatic brain injury in rats. Johnson EA, etal., J Neurotrauma. 2004 Sep;21(9):1183-95.
22. Survivin is a key factor in the differential susceptibility of gastric endothelial and epithelial cells to alcohol-induced injury. Jones MK, etal., J Physiol Pharmacol. 2010 Jun;61(3):253-64.
23. Survivin expression in patients with non-muscle-invasive urothelial cell carcinoma of the bladder. Karam JA, etal., Urology. 2007 Sep;70(3):482-6.
24. Intracranial stereotaxic cannulation for development of orthotopic glioblastoma allograft in Sprague-Dawley rats and histoimmunopathological characterization of the brain tumor. Karmakar S, etal., Neurochem Res. 2007 Dec;32(12):2235-42. Epub 2007 Aug 15.
25. Gene Expression of Survivin and Its Spliced Isoforms Associated with Proliferation and Aggressive Phenotypes of Prostate Cancer. Koike H, etal., Urology. 2008 Mar 10;.
26. Survivin and b7-h1 are collaborative predictors of survival and represent potential therapeutic targets for patients with renal cell carcinoma. Krambeck AE, etal., Clin Cancer Res. 2007 Mar 15;13(6):1749-56.
27. The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney. Lechler P, etal., Am J Pathol. 2007 Nov;171(5):1483-98.
28. Survivin determines cardiac function by controlling total cardiomyocyte number. Levkau B, etal., Circulation. 2008 Mar 25;117(12):1583-93. Epub 2008 Mar 10.
29. [Expression of survivin gene in a rat model of acute pancreatitis]. Li ZD, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jun;29(6):1141-3.
30. Nimesulide inhibits the growth of human esophageal carcinoma cells by inactivating the JAK2/STAT3 pathway. Liu JR, etal., Pathol Res Pract. 2015 Jun;211(6):426-34. doi: 10.1016/j.prp.2015.01.007. Epub 2015 Jan 24.
31. [Effect of hypoxic preconditioning on the learning and memory ability and expressions of survivin and HSP-70 proteins in rats with focal cerebral ischemia/reperfusion injury] Lu N, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2007 Dec;27(12):1856-9.
32. Distinct in vivo expression patterns of survivin splice variants in renal cell carcinomas. Mahotka C, etal., Int J Cancer. 2002 Jul 1;100(1):30-6.
33. Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats. Marsillach J, etal., Mol Cell Biochem. 2008 Jan;308(1-2):101-9. Epub 2007 Oct 16.
34. Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. McMurtry MS, etal., J Clin Invest. 2005 Jun;115(6):1479-91.
35. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
36. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Nakahara T, etal., Cancer Res. 2007 Sep 1;67(17):8014-21.
37. Survivin and caspase-3 expression in breast cancer: correlation with prognostic parameters, proliferation, angiogenesis, and outcome. Nassar A, etal., Appl Immunohistochem Mol Morphol. 2008 Mar;16(2):113-20.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Functional pathway characterized by gene expression analysis of supraclavicular lymph node metastasis-positive breast cancer. Oishi Y, etal., J Hum Genet. 2007;52(3):271-9. Epub 2007 Feb 7.
40. Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in rats. Okazaki T, etal., Neurosci Lett. 2008 Jan 10;430(2):109-14. Epub 2007 Nov 6.
41. Expression of antiapoptotic survivin and aven genes in rat heart tissue after traumatic brain injury. Ozisik K, etal., Transplant Proc. 2006 Nov;38(9):2784-7.
42. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
43. Detection of survivin mRNA in urine of patients with superficial urothelial cell carcinomas. Pina-Cabral L, etal., Clin Transl Oncol. 2007 Nov;9(11):731-6.
44. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
45. GOA pipeline RGD automated data pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Comprehensive gene review and curation RGD comprehensive gene curation
49. Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. Singh RP, etal., Clin Cancer Res. 2008 Jan 1;14(1):300-8.
50. Inhibitor of apoptosis protein (IAP) survivin is upregulated by oncogenic c-H-Ras. Sommer KW, etal., Oncogene 2003 Jul 3;22(27):4266-80.
51. The survivin:fas ratio in pediatric renal tumors. Takamizawa S, etal., J Pediatr Surg. 2001 Jan;36(1):37-42.
52. Expression of survivin after acute necrohemorrhagic pancreatitis in rats. Tashiro M, etal., Pancreas. 2003 Mar;26(2):160-5.
53. Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice. Tyagi A, etal., Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3248-55.
54. Expression and prognostic significance of survivin in the progression of bladder transitional cell cancer. Wang Y, etal., J Huazhong Univ Sci Technolog Med Sci. 2007 Aug;27(4):444-7.
55. Survivin expression in rat testis is upregulated by stem-cell factor. Wang Y, etal., Mol Cell Endocrinol. 2004 Apr 15;218(1-2):165-74.
56. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban Wei SB, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Feb;28(2):139-41.
57. Analysis of molecular pathological factors of unfavorable prognosis for young cervical cancer patients. Yi L, etal., Onkologie. 2007 Oct;30(10):502-6. Epub 2007 Sep 21.
58. Detection of Survivin-expressing circulating cancer cells in the peripheral blood of breast cancer patients by a RT-PCR ELISA. Yie SM, etal., Clin Exp Metastasis. 2006;23(5-6):279-89. Epub 2006 Nov 3.
59. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Yin RT, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Mar;38(2):243-5.
60. Expression of survivin in human gastric carcinoma and gastric carcinoma model of rats. Zhu XD, etal., World J Gastroenterol. 2003 Jul;9(7):1435-8.
61. Diagnosis of bladder cancer by urine survivin, an inhibitor of apoptosis: a preliminary report. Ziaee SA, etal., Urol J. 2006 Summer;3(3):150-3.
Additional References at PubMed
PMID:9859993   PMID:10626797   PMID:10876248   PMID:10949039   PMID:11069302   PMID:11084331   PMID:11516652   PMID:12679106   PMID:12773388   PMID:12805209   PMID:15260989   PMID:15665297  
PMID:16049172   PMID:16239925   PMID:16291752   PMID:16322459   PMID:17099693   PMID:17428462   PMID:18086682   PMID:18358624   PMID:18591255   PMID:19018973   PMID:19035263   PMID:19073407  
PMID:19576024   PMID:19644667   PMID:20514400   PMID:20564420   PMID:20627126   PMID:20826784   PMID:20887644   PMID:21252625   PMID:21364656   PMID:21536684   PMID:21706383   PMID:21708067  
PMID:21976248   PMID:22139302   PMID:22819929   PMID:22883038   PMID:23251006   PMID:23658701   PMID:23884942   PMID:24935577   PMID:25318914   PMID:25323860   PMID:25539851   PMID:25744839  
PMID:25778398   PMID:25816072   PMID:25843524   PMID:25856227   PMID:26347229   PMID:26464661   PMID:26818429   PMID:27046449   PMID:27539959   PMID:28218735   PMID:30251448   PMID:33568044  
PMID:34783140   PMID:35202039  


Genomics

Comparative Map Data
Birc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,567,369 - 103,580,069 (+)NCBIGRCr8
mRatBN7.210103,072,530 - 103,081,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,073,408 - 103,081,380 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,174,435 - 108,182,841 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,637,549 - 107,645,954 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010102,994,242 - 103,002,165 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,856,097 - 106,864,419 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,856,097 - 106,864,413 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,494,775 - 106,503,097 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10101,633,441 - 101,641,341 (+)NCBICelera
Cytogenetic Map10q32.2NCBI
BIRC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,214,253 - 78,225,635 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,214,186 - 78,225,636 (+)EnsemblGRCh38hg38GRCh38
GRCh371776,210,334 - 76,221,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,721,872 - 73,733,311 (+)NCBINCBI36Build 36hg18NCBI36
Build 341773,721,871 - 73,733,310NCBI
Celera1772,806,306 - 72,817,744 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,634,433 - 71,645,847 (+)NCBIHuRef
CHM1_11776,274,801 - 76,286,240 (+)NCBICHM1_1
T2T-CHM13v2.01779,108,345 - 79,119,727 (+)NCBIT2T-CHM13v2.0
Birc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,740,063 - 117,746,569 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,740,077 - 117,746,569 (+)EnsemblGRCm39 Ensembl
GRCm3811117,849,237 - 117,855,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,849,251 - 117,855,743 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711117,710,551 - 117,717,057 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611117,665,327 - 117,671,833 (+)NCBIMGSCv36mm8
Celera11129,594,259 - 129,600,765 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.96NCBI
BIRC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21994,265,019 - 94,276,237 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11799,094,471 - 99,105,679 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,292,332 - 72,303,493 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11777,842,724 - 77,854,159 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1777,842,724 - 77,854,159 (+)Ensemblpanpan1.1panPan2
BIRC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,930,308 - 2,959,307 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,613,921 - 3,619,074 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.093,608,303 - 3,613,418 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.193,631,386 - 3,636,494 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,755,584 - 3,761,556 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,836,949 - 3,842,103 (-)NCBIUU_Cfam_GSD_1.0
Birc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,591,620 - 3,599,727 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365942,812,238 - 2,820,636 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365942,812,165 - 2,820,618 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BIRC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,747,279 - 3,755,215 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1123,747,276 - 3,755,214 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BIRC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,226,824 - 70,237,000 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607741,335,707 - 41,347,619 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Birc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248017,727,093 - 7,735,940 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248017,727,084 - 7,735,946 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Birc5
115 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:434
Count of miRNA genes:240
Interacting mature miRNAs:286
Transcripts:ENSRNOT00000072387
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 26 33 26 17 26 53 21 37
Low 15 24 15 2 15 4 7 21 14 4 11 4
Below cutoff 2 4 4 4

Sequence


RefSeq Acc Id: ENSRNOT00000072387   ⟹   ENSRNOP00000065784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,073,408 - 103,081,380 (+)Ensembl
Rnor_6.0 Ensembl10106,856,097 - 106,864,413 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096623   ⟹   ENSRNOP00000076513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,073,408 - 103,078,854 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106040   ⟹   ENSRNOP00000095300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,073,476 - 103,081,380 (+)Ensembl
RefSeq Acc Id: NM_022274   ⟹   NP_071610
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,572,146 - 103,580,069 (+)NCBI
mRatBN7.210103,073,459 - 103,081,382 (+)NCBI
Rnor_6.010106,856,097 - 106,864,419 (+)NCBI
Rnor_5.010106,494,775 - 106,503,097 (+)NCBI
Celera10101,633,441 - 101,641,341 (+)RGD
Sequence:
RefSeq Acc Id: XM_063269805   ⟹   XP_063125875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,567,369 - 103,580,067 (+)NCBI
RefSeq Acc Id: NP_071610   ⟸   NM_022274
- UniProtKB: Q9JHY7 (UniProtKB/Swiss-Prot),   A6HL35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065784   ⟸   ENSRNOT00000072387
RefSeq Acc Id: ENSRNOP00000076513   ⟸   ENSRNOT00000096623
RefSeq Acc Id: ENSRNOP00000095300   ⟸   ENSRNOT00000106040
RefSeq Acc Id: XP_063125875   ⟸   XM_063269805
- Peptide Label: isoform X1
- UniProtKB: M0R8I8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHY7-F1-model_v2 AlphaFold Q9JHY7 1-142 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697934
Promoter ID:EPDNEW_R8459
Type:multiple initiation site
Name:Birc5_1
Description:baculoviral IAP repeat-containing 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010106,856,074 - 106,856,134EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70499 AgrOrtholog
BioCyc Gene G2FUF-22534 BioCyc
Ensembl Genes ENSRNOG00000050819 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072387 ENTREZGENE
  ENSRNOT00000072387.2 UniProtKB/TrEMBL
  ENSRNOT00000096623.1 UniProtKB/TrEMBL
  ENSRNOT00000106040.1 UniProtKB/TrEMBL
InterPro BIR_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64041 UniProtKB/Swiss-Prot
NCBI Gene 64041 ENTREZGENE
PANTHER BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DETERIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Birc5 PhenoGen
PROSITE BIR_REPEAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050819 RatGTEx
SMART BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Inhibitor of apoptosis (IAP) repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5XV25_RAT UniProtKB/TrEMBL
  A0A8I6GLK0_RAT UniProtKB/TrEMBL
  A6HL35 ENTREZGENE, UniProtKB/TrEMBL
  A6HL36_RAT UniProtKB/TrEMBL
  A6HL37_RAT UniProtKB/TrEMBL
  BIRC5_RAT UniProtKB/Swiss-Prot
  M0R8I8 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHY7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Birc5  baculoviral IAP repeat-containing 5    baculoviral IAP repeat-containing 5 (survivin)  Name updated 1299863 APPROVED
2002-06-10 Birc5  baculoviral IAP repeat-containing 5 (survivin)      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in transformed cell lines and lung, colon, pancreas, prostate and breast cancer tissue 70286