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Gene: Birc5 (baculoviral IAP repeat-containing 5) Rattus norvegicus
Symbol: Birc5
Name: baculoviral IAP repeat-containing 5
RGD ID: 70499
Description: Predicted to have several functions, including chaperone binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and protein dimerization activity. Involved in several processes, including cellular response to ethanol; cellular response to stem cell factor stimulus; and response to glucocorticoid. Localizes to apical plasma membrane; cytoplasm; and nucleus. Used to study endometriosis and pulmonary hypertension. Biomarker of acute pancreatitis; artery disease (multiple); congestive heart failure; malignant glioma; and stomach carcinoma. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5); PARTICIPATES IN histone modification pathway; colorectal cancer pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
Also known as: AP14; apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; survivin
Homo sapiens (human) : BIRC5 (baculoviral IAP repeat containing 5)  HGNC  Alliance
Mus musculus (house mouse) : Birc5 (baculoviral IAP repeat-containing 5)  MGI  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : BIRC5 (baculoviral IAP repeat containing 5)
Canis lupus familiaris (dog) : BIRC5 (baculoviral IAP repeat containing 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Birc5 (baculoviral IAP repeat containing 5)
Sus scrofa (pig) : BIRC5 (baculoviral IAP repeat containing 5)
Chlorocebus sabaeus (African green monkey) : BIRC5 (baculoviral IAP repeat containing 5)
Heterocephalus glaber (naked mole-rat) : Birc5 (baculoviral IAP repeat containing 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.010106,856,097 - 106,864,419 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,856,097 - 106,864,413 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,494,775 - 106,503,097 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10101,633,441 - 101,641,341 (+)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Birc5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 70499
Created: 2002-05-02
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.