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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70499
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Birc5
Name: baculoviral IAP repeat-containing 5
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Birc5decreases expressionISOBIRC5 (Homo sapiens)6480464CTDBortezomib results in decreased expression of BIRC5 mRNA; Bortezomib results in decreased expression of BIRC5 proteinPMID:17898295 PMID:18850583 PMID:19636294 PMID:20977926
Birc5increases expressionISOBIRC5 (Homo sapiens)6480464CTDBortezomib results in increased expression of BIRC5 proteinPMID:17510429
Birc5multiple interactionsISOBIRC5 (Homo sapiens)6480464CTD[Irinotecan co-treated with Bortezomib] results in decreased expression of BIRC5 protein; [romidepsin co-treated with Bortezomib] results in increased cleavage of BIRC5 protein; Bortezomib promotes the reaction [capillarisin results in decreased expression of BIRC5 protein]PMID:16373703 PMID:18223231 PMID:24333736
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