RGD Reference Report - Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats. - Rat Genome Database

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Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats.

Authors: Marsillach, J  Ferre, N  Camps, J  Rull, A  Beltran, R  Joven, J 
Citation: Marsillach J, etal., Mol Cell Biochem. 2008 Jan;308(1-2):101-9. Epub 2007 Oct 16.
RGD ID: 2293129
Pubmed: PMID:17938867   (View Abstract at PubMed)
DOI: DOI:10.1007/s11010-007-9617-0   (Journal Full-text)

Chronic liver diseases are accompanied by changes in the biochemical pathways related to the regulation of apoptosis and extra-cellular matrix deposition. The present study was designed to investigate, using low density arrays, changes in the hepatic gene expression together with hepatic biochemical and histological alterations in rats that had liver impairment induced by chronic exposure to CCl(4). Further, we examined the possible recovery of genetic and pathological changes following the cessation of the hepatotoxic injury. Experimental fibrosis was induced in male Wistar rats by CCl(4) administration. Animals were subdivided into two groups. One group was given CCl(4 )and animals were killed at 8 and 12 weeks of treatment. The other group was treated with CCl(4) for 6 weeks, the CCl(4 )was then stopped and, subsequently, subgroups of animals were killed after 1 and 2 weeks of recovery. CCl(4) administration over 12 weeks was associated with significant changes in B-cell leukemia/lymphoma 2, procollagen type I alpha 2, matrix metalloproteinases 3 and 8, tissue inhibitors of metalloproteinases 1, 2, and 3 and the inhibitor of apoptosis 4 gene expressions. Recovery after CCl(4) cessation was associated with changes in procollagen type I alpha 2, matrix metalloproteinase 7, tissue inhibitors of metalloproteinases 1 and 2, inhibitor of apoptosis 4, and survivin gene expressions. This study shows an association between changes in the expression of several genes regulating hepatic cell apoptosis, the fibrosis process, and the recovery of the hepatic function after removal of the toxic injury.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Liver Cirrhosis  ISOBcl2 (Rattus norvegicus)2293129; 2293129mRNA:increased expression:liver (rat)RGD 
Experimental Liver Cirrhosis  ISOBirc5 (Rattus norvegicus)2293129; 2293129 RGD 
Experimental Liver Cirrhosis  IEP 2293129mRNA:increased expression:liver (rat)RGD 
Experimental Liver Cirrhosis  IEP 2293129 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bcl2  (BCL2, apoptosis regulator)
Birc5  (baculoviral IAP repeat-containing 5)

Genes (Mus musculus)
Bcl2  (B cell leukemia/lymphoma 2)
Birc5  (baculoviral IAP repeat-containing 5)

Genes (Homo sapiens)
BCL2  (BCL2 apoptosis regulator)
BIRC5  (baculoviral IAP repeat containing 5)


Additional Information