BIRC5 (baculoviral IAP repeat containing 5) - Rat Genome Database

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Gene: BIRC5 (baculoviral IAP repeat containing 5) Canis lupus familiaris
Analyze
Symbol: BIRC5
Name: baculoviral IAP repeat containing 5
RGD ID: 12244289
Description: ENCODES a protein that exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN cell division (ortholog); cellular response to ethanol (ortholog); cellular response to stem cell factor stimulus (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH acute megakaryocytic leukemia (ortholog); acute necrotizing pancreatitis (ortholog); acute pancreatitis (ortholog); FOUND IN apical plasma membrane (ortholog); centriole (ortholog); chromosome passenger complex (ortholog); INTERACTS WITH masitinib
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; survivin
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,930,308 - 2,959,307 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,613,921 - 3,619,074 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.093,608,303 - 3,613,418 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.193,631,386 - 3,636,494 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,755,584 - 3,761,556 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,836,949 - 3,842,103 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute megakaryocytic leukemia  (ISO)
acute necrotizing pancreatitis  (ISO)
acute pancreatitis  (ISO)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
adrenocortical carcinoma  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
bladder urothelial carcinoma  (ISO)
brain glioma  (ISO)
Brain Injuries  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
chromophobe renal cell carcinoma  (ISO)
chronic myeloid leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
COVID-19  (ISO)
ductal carcinoma in situ  (ISO)
endometrial hyperplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
genetic disease  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Kidney Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant pleural mesothelioma  (ISO)
Mesothelioma  (ISO)
myocardial infarction  (ISO)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic adenocarcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
Refractory Anemia  (ISO)
Refractory Anemia with Excess of Blasts  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
small cell carcinoma  (ISO)
squamous cell carcinoma  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Testicular Germ Cell Tumor  (ISO)
thymoma  (ISO)
thyroid gland carcinoma  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
masitinib  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16243724   PMID:18479697   PMID:18647159   PMID:18672973   PMID:20178473   PMID:22681570   PMID:24800266   PMID:24923332   PMID:28865215  


Genomics

Comparative Map Data
BIRC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,930,308 - 2,959,307 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,613,921 - 3,619,074 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.093,608,303 - 3,613,418 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.193,631,386 - 3,636,494 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,755,584 - 3,761,556 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,836,949 - 3,842,103 (-)NCBIUU_Cfam_GSD_1.0
BIRC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,214,253 - 78,225,635 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,214,186 - 78,225,636 (+)EnsemblGRCh38hg38GRCh38
GRCh371776,210,334 - 76,221,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,721,872 - 73,733,311 (+)NCBINCBI36Build 36hg18NCBI36
Build 341773,721,871 - 73,733,310NCBI
Celera1772,806,306 - 72,817,744 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,634,433 - 71,645,847 (+)NCBIHuRef
CHM1_11776,274,801 - 76,286,240 (+)NCBICHM1_1
T2T-CHM13v2.01779,108,345 - 79,119,727 (+)NCBIT2T-CHM13v2.0
Birc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,740,063 - 117,746,569 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,740,077 - 117,746,569 (+)EnsemblGRCm39 Ensembl
GRCm3811117,849,237 - 117,855,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,849,251 - 117,855,743 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711117,710,551 - 117,717,057 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611117,665,327 - 117,671,833 (+)NCBIMGSCv36mm8
Celera11129,594,259 - 129,600,765 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.96NCBI
Birc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,567,369 - 103,580,069 (+)NCBIGRCr8
mRatBN7.210103,072,530 - 103,081,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,073,408 - 103,081,380 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,174,435 - 108,182,841 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,637,549 - 107,645,954 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010102,994,242 - 103,002,165 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,856,097 - 106,864,419 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,856,097 - 106,864,413 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,494,775 - 106,503,097 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10101,633,441 - 101,641,341 (+)NCBICelera
Cytogenetic Map10q32.2NCBI
BIRC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21994,265,019 - 94,276,237 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11799,094,471 - 99,105,679 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,292,332 - 72,303,493 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11777,842,724 - 77,854,159 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1777,842,724 - 77,854,159 (+)Ensemblpanpan1.1panPan2
Birc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,591,620 - 3,599,727 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365942,812,238 - 2,820,636 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365942,812,165 - 2,820,618 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BIRC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,747,279 - 3,755,215 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1123,747,276 - 3,755,214 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BIRC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,226,824 - 70,237,000 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607741,335,707 - 41,347,619 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Birc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248017,727,093 - 7,735,940 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248017,727,084 - 7,735,946 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BIRC5
291 total Variants

Expression


Sequence


RefSeq Acc Id: NM_001003348   ⟹   NP_001003348
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.192,930,308 - 2,935,461 (-)NCBI
Dog10K_Boxer_Tasha93,613,921 - 3,619,074 (-)NCBI
ROS_Cfam_1.093,608,303 - 3,613,418 (-)NCBI
UMICH_Zoey_3.193,631,386 - 3,636,494 (-)NCBI
UNSW_CanFamBas_1.093,755,584 - 3,761,556 (-)NCBI
UU_Cfam_GSD_1.093,836,949 - 3,842,103 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001003348 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAU89275 (Get FASTA)   NCBI Sequence Viewer  
  AMK38056 (Get FASTA)   NCBI Sequence Viewer  
  BAD20570 (Get FASTA)   NCBI Sequence Viewer  
  Q8I009 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001003348   ⟸   NM_001003348
- UniProtKB: Q5XPZ7 (UniProtKB/Swiss-Prot),   Q6L673 (UniProtKB/Swiss-Prot),   Q8I009 (UniProtKB/Swiss-Prot),   A0A140DDC9 (UniProtKB/TrEMBL),   A0A8C0K0Z7 (UniProtKB/TrEMBL)
- Sequence:

Promoters
RGD ID:13684404
Promoter ID:EPDNEW_C2472
Type:initiation region
Name:BIRC5_1
Description:baculoviral IAP repeat containing 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.192,935,431 - 2,935,491EPDNEW

Additional Information

Database Acc Id Source(s)
InterPro BIR_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:442936 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene BIRC5 ENTREZGENE
PANTHER BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DETERIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BIR_REPEAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Inhibitor of apoptosis (IAP) repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140DDC9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0K0Z7 ENTREZGENE
  BIRC5_CANLF UniProtKB/Swiss-Prot
  Q5XPZ7 ENTREZGENE
  Q6L673 ENTREZGENE
  Q8I009 ENTREZGENE
UniProt Secondary Q5XPZ7 UniProtKB/Swiss-Prot
  Q6L673 UniProtKB/Swiss-Prot
VGNC ID VGNC:38461 ENTREZGENE