GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Birc5 | decreases expression | ISO | Birc5 (Mus musculus) | 6480464 | CTD | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of BIRC5 mRNA | PMID:25566086 | Birc5 | increases expression | ISO | BIRC5 (Homo sapiens) | 6480464 | CTD | benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of BIRC5 protein | PMID:16328441 PMID:17510429 | Birc5 | multiple interactions | ISO | Birc5 (Mus musculus) | 6480464 | CTD | benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Topotecan results in increased degradation of BIRC5 protein] | PMID:19812371 | Birc5 | multiple interactions | ISO | BIRC5 (Homo sapiens) | 6480464 | CTD | [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with dihydromyricetin] results in increased ubiquitination of BIRC5 protein; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with MK 2206] results in increased ubiquitination of BIRC5 protein; AKT1 protein modified form inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with dihydromyricetin] results in increased ubiquitination of BIRC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [(+)-JQ1 compound results in decreased expression of BIRC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of BIRC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Capsaicin results in decreased expression of BIRC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [dihydromyricetin results in decreased expression of BIRC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Quercetin results in decreased expression of BIRC5 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased susceptibility to [Oxaliplatin results in decreased expression of BIRC5 protein] | PMID:17548900 PMID:19812371 PMID:19939880 PMID:20708607 PMID:23872705 PMID:36807944 | |
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