GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Birc5 | decreases expression | ISO | BIRC5 (Homo sapiens) | 6480464 | CTD | Sirolimus results in decreased expression of BIRC5 protein | PMID:19931998 PMID:21601561 | Birc5 | multiple interactions | ISO | BIRC5 (Homo sapiens) | 6480464 | CTD | [fulvestrant co-treated with Sirolimus] results in decreased expression of BIRC5 mRNA; Sirolimus inhibits the reaction [N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide results in increased expression of and affects the localization of BIRC5 protein]; Sirolimus promotes the reaction [Tamoxifen results in decreased expression of BIRC5 protein] | PMID:19016759 PMID:19931998 PMID:24444656 | |
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