RGD Reference Report - The prognostic significance of COX-2 and survivin expression in ovarian cancer. - Rat Genome Database

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The prognostic significance of COX-2 and survivin expression in ovarian cancer.

Authors: Athanassiadou, P  Grapsa, D  Athanassiades, P  Gonidi, M  Athanassiadou, AM  Tsipis, A  Patsouris, E 
Citation: Athanassiadou P, etal., Pathol Res Pract. 2008;204(4):241-9. Epub 2008 Jan 2.
RGD ID: 2298936
Pubmed: PMID:18171606   (View Abstract at PubMed)
DOI: DOI:10.1016/j.prp.2007.11.004   (Journal Full-text)

We investigated the prognostic significance of cyclooxygenase-2 (COX-2) and survivin in ovarian carcinoma. Imprint smears were obtained from 100 ovarian carcinoma specimens and were studied immunocytochemically for the expression of COX-2 and survivin. The results were correlated with several clinicopathological parameters, including 5-year survival. Increased COX-2 staining pattern correlated with a non-mucinous histological type (p=0.008), increased stage (p<0.0001), high histological grade (p<0.0001), and reduced survival rates (p<0.00001). Survivin expression was strongly associated with increased stage (p<0.0001), increased histological grade (p<0.0001), and reduced survival (p<0.00001). Elevated survivin expression also correlated significantly with pre-menopausal status (p=0.033). In addition, COX-2 and survivin staining patterns correlated strongly with one another (p<0.0001). However, on multivariate analysis, an independent prognostic value was found only for tumor stage and grade. The findings of our study indicate that the increased expression of COX-2 and survivin in ovarian cancer is associated with one another and with several adverse clinicopathologic parameters, including reduced survival, thus suggesting a role of these molecules in disease progression. Further investigations of the exact prognostic and therapeutic implications of COX-2 and survivin expression are strongly warranted.




  
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Original Reference(s)
BIRC5HumanOvarian Neoplasms disease_progressionIEP  RGD 
Birc5RatOvarian Neoplasms disease_progressionISOBIRC5 (Homo sapiens) RGD 
Birc5MouseOvarian Neoplasms disease_progressionISOBIRC5 (Homo sapiens) RGD 
PTGS2HumanOvarian Neoplasms disease_progressionIEP  RGD 
Ptgs2RatOvarian Neoplasms disease_progressionISOPTGS2 (Homo sapiens) RGD 
Ptgs2MouseOvarian Neoplasms disease_progressionISOPTGS2 (Homo sapiens) RGD 


Genes (Rattus norvegicus)
Birc5  (baculoviral IAP repeat-containing 5) Ptgs2  (prostaglandin-endoperoxide synthase 2)

Genes (Mus musculus)
Birc5  (baculoviral IAP repeat-containing 5) Ptgs2  (prostaglandin-endoperoxide synthase 2)

Genes (Homo sapiens)
BIRC5  (baculoviral IAP repeat containing 5) PTGS2  (prostaglandin-endoperoxide synthase 2)