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Gene: PTGS2 (prostaglandin-endoperoxide synthase 2) Homo sapiens
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Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Description: Exhibits enzyme binding activity and prostaglandin-endoperoxide synthase activity. Involved in cellular response to hypoxia and cyclooxygenase pathway. Localizes to the endoplasmic reticulum and neuron projection. Implicated in several diseases, including arthritis (multiple); avian influenza; cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Biomarker of several diseases, including carcinoma (multiple); functioning pituitary adenoma (multiple); in situ carcinoma (multiple); neurodegenerative disease (multiple); and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: COX-2; COX2; cyclooxygenase 2; cyclooxygenase 2b; cyclooxygenase-2; GRIPGHS; hCox-2; PGG/HS; PGH synthase 2; PGHS-2; PHS II; PHS-2; prostaglandin G/H synthase 2; prostaglandin G/H synthase and cyclooxygenase; prostaglandin H2 synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Orthologs:
Mus musculus (house mouse) : Ptgs2 (prostaglandin-endoperoxide synthase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptgs2 (prostaglandin-endoperoxide synthase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptgs2 (prostaglandin-endoperoxide synthase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PTGS2 (prostaglandin-endoperoxide synthase 2)
Canis lupus familiaris (dog) : PTGS2 (prostaglandin-endoperoxide synthase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptgs2 (prostaglandin-endoperoxide synthase 2)
Sus scrofa (pig) : PTGS2 (prostaglandin-endoperoxide synthase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,671,791 - 186,680,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371186,640,944 - 186,649,559 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361184,907,592 - 184,916,179 (-)NCBINCBI36hg18NCBI36
Build 341183,372,625 - 183,381,213NCBI
Celera1159,751,694 - 159,760,309 (-)NCBI
Cytogenetic Map1q31.1NCBI
HuRef1157,875,712 - 157,884,327 (-)NCBIHuRef
CHM1_11188,062,673 - 188,071,288 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model