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Gene: BIRC5 (baculoviral IAP repeat containing 5) Homo sapiens
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Symbol: BIRC5
Name: baculoviral IAP repeat containing 5
Description: Exhibits several functions, including chaperone binding activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; and protein dimerization activity. Involved in several processes, including G2/M transition of mitotic cell cycle; negative regulation of nitrogen compound metabolic process; and regulation of mitotic nuclear division. Localizes to several cellular components, including the chromosome; microtubule cytoskeleton; and midbody. Implicated in prostate cancer and transitional cell carcinoma. Biomarker of several diseases, including ductal carcinoma in situ; endometrial hyperplasia; prostate cancer; pulmonary hypertension; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: API4; apoptosis inhibitor 4; apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5; baculoviral IAP repeat-containing protein 5; EPR-1; survivin variant 3 alpha
Orthologs:
Mus musculus (house mouse) : Birc5 (baculoviral IAP repeat-containing 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Birc5 (baculoviral IAP repeat-containing 5)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : BIRC5 (baculoviral IAP repeat containing 5)
Canis lupus familiaris (dog) : BIRC5 (baculoviral IAP repeat containing 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Birc5 (baculoviral IAP repeat containing 5)
Sus scrofa (pig) : BIRC5 (baculoviral IAP repeat containing 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,214,253 - 78,225,635 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371776,210,277 - 76,221,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,721,872 - 73,733,311 (+)NCBINCBI36hg18NCBI36
Build 341773,721,871 - 73,733,310NCBI
Celera1772,806,306 - 72,817,744 (+)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1771,634,433 - 71,645,847 (+)NCBIHuRef
CHM1_11776,274,801 - 76,286,240 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on BIRC5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737482
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.