Ptgs2 (prostaglandin-endoperoxide synthase 2) - Rat Genome Database

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Gene: Ptgs2 (prostaglandin-endoperoxide synthase 2) Rattus norvegicus
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Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
RGD ID: 620349
Description: Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and positive regulation of cytokine production. Acts upstream of or within bone mineralization. Located in cytoplasm. Part of protein-containing complex. Colocalizes with caveola. Used to study several diseases, including brain disease (multiple); hypertension (multiple); liver disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including carcinoma (multiple); glioblastoma (multiple); inflammatory bowel disease (multiple); pleurisy; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); avian influenza; cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (1->4)-beta-D-glucan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: COX-2; Cox2; cyclooxygenase 2; cyclooxygenase-2; PGH synthase 2; PGHS-2; PHS II; prostaglandin G/H synthase 2; prostaglandin H2 synthase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Ptgs2em1Mcwi   Ptgs2em2Mcwi  
Genetic Models: SS-Ptgs2em1Mcwi SS-Ptgs2em2Mcwi
Candidate Gene For: Bp329
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,714,063 - 64,722,320 (+)NCBIGRCr8
mRatBN7.21362,163,936 - 62,172,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1362,163,932 - 62,172,188 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1364,798,537 - 64,804,239 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01366,083,346 - 66,089,057 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,344,882 - 63,350,588 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,351,230 - 67,356,920 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,351,087 - 67,359,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,315,959 - 72,324,483 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,427,288 - 64,432,978 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11364,441,245 - 64,449,480 (+)NCBI
Celera1362,129,439 - 62,135,131 (+)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acute kidney failure  (IMP)
Acute Liver Failure  (IMP,ISO)
Acute Lung Injury  (IEP,ISO)
adenocarcinoma  (IMP,ISO)
Adrenal Gland Neoplasms  (ISO)
Albuminuria  (ISO)
Alcohol Withdrawal Delirium  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (IMP,ISO)
amyotrophic lateral sclerosis  (ISO)
Anaphylaxis  (IMP,ISO)
Anorexia  (IMP)
arteriosclerosis  (ISO)
asphyxia neonatorum  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
avian influenza  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
B-cell lymphoma  (ISO)
Barrett's esophagus  (IMP,ISO)
bipolar disorder  (ISO)
bladder neck obstruction  (ISO)
Bone Fractures  (IMP)
Bone Neoplasms  (ISO)
Brain Injuries  (IMP,ISO)
brain ischemia  (IDA,IEP,ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cachexia  (ISO)
Calcification of Aortic Valve  (ISO)
carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
cardiomyopathy  (ISO)
cardiovascular system disease  (ISO)
Cerebral Hemorrhage  (IEP,ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
cognitive disorder  (ISO)
colitis  (IEP,ISO)
Colonic Neoplasms  (IMP,ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Cough  (ISO)
COVID-19  (ISO)
Creutzfeldt-Jakob disease  (ISO)
Crohn's disease  (IEP)
cryptorchidism  (ISO)
cystic fibrosis  (ISO)
cystitis  (IMP)
demyelinating disease  (ISO)
depressive disorder  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IMP)
diabetic neuropathy  (IEP,IMP)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
ductal carcinoma in situ  (ISO)
duodenal ulcer  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (IDA,IMP,ISO)
Endotoxemia  (IEP)
Esophageal Neoplasms  (IEP,ISO)
esophagitis  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (IEP,IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (IEP,ISO)
Experimental Autoimmune Neuritis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (IEP,IMP,ISO)
Experimental Radiation Injuries  (IEP)
familial adenomatous polyposis  (ISO)
Fetal Growth Retardation  (IEP)
Fever  (IMP,ISO)
Fibrosis  (IMP,ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (IMP,ISO)
gastritis  (IMP)
gastroesophageal reflux disease  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
glioblastoma  (IEP,ISO)
gliosarcoma  (IEP)
granulosa cell tumor  (ISO)
Graves ophthalmopathy  (ISO)
growth hormone secreting pituitary adenoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (IEP)
Human Influenza  (ISO)
Huntington's disease  (IMP)
hydronephrosis  (ISO)
Hyperalgesia  (IMP,ISO)
Hyperemia  (ISO)
hyperglycemia  (ISO)
Hyperplasia  (ISO)
hypertension  (IAGP,ISO)
Hypoxia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
in situ carcinoma  (ISO)
Inflammation  (IMP,ISO)
inflammatory bowel disease  (ISO)
intestinal obstruction  (IEP)
Intestinal Polyps  (ISO)
invasive ductal carcinoma  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Laryngeal Neoplasms  (ISO)
Laryngeal Papillomatosis  (ISO)
Left Ventricular Hypertrophy  (IMP)
leiomyosarcoma  (ISO)
liver cirrhosis  (ISO)
lung cancer  (IMP)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (IEP)
mouth disease  (ISO)
Mouth Neoplasms  (IMP,ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IMP)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (IMP,ISO)
Neoplasm Recurrence, Local  (ISO)
nephroblastoma  (ISO)
nephrotic syndrome  (IMP)
nervous system disease  (ISO)
Neurogenic Inflammation  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
occupational asthma  (ISO)
open-angle glaucoma  (ISO)
oral mucosa leukoplakia  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (IEP,IMP,ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
papilloma  (ISO)
parathyroid carcinoma  (ISO)
Parkinsonism  (IDA,ISO)
pericardial effusion  (ISO)
Peripheral Nerve Injuries  (IEP,ISO)
pleurisy  (IDA,IEP)
polycystic kidney disease  (IMP)
portal hypertension  (IMP)
pre-malignant neoplasm  (ISO)
Precocious Puberty  (ISO)
Premature Birth  (ISO)
prolactinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (IEP)
proteinuria  (ISO)
pulmonary emphysema  (IMP)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IMP,ISO)
renal cell carcinoma  (IEP,ISO)
Reperfusion Injury  (IDA,IEP,IMP,ISO)
retrograde amnesia  (IMP)
rheumatoid arthritis  (ISO)
sarcoidosis  (ISO)
schizophrenia  (IEP)
secondary hyperparathyroidism  (IMP,ISO)
skin disease  (ISO)
Skin Neoplasms  (ISO)
Sleep Deprivation  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (ISO)
status epilepticus  (IMP,ISO)
steatotic liver disease  (IMP)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombosis  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
traumatic brain injury  (ISO)
type 2 diabetes mellitus  (IEP)
ulcerative colitis  (IMP)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
Uterine Cervical Neoplasms  (ISO)
Ventilator-Induced Lung Injury  (IMP)
visual epilepsy  (IEP)
Wernicke encephalopathy  (IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(+)-isolariciresinol  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-pinoresinol  (ISO)
(+)-syringaresinol  (ISO)
(+)-syringaresinol beta-D-glucoside  (ISO)
(+)-taxifolin  (ISO)
(-)-Arctigenin  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (EXP)
(1S)-bornane-2,3-dione  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid  (EXP)
(E)-thiamethoxam  (ISO)
(R)-adrenaline  (ISO)
(R)-amygdalin  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4-trimethylbenzene  (EXP,ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,2-dioctanoyl-sn-glycero-3-phosphate  (ISO)
1,2-naphthoquinone  (ISO)
1,3,5-trinitrobenzene  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-methylnicotinamide  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
1-Phenyl-6,7-dihydroxy-isochroman  (ISO)
11-deoxycorticosterone  (EXP)
11-deoxyprostaglandin E1  (ISO)
12(S)-HPETE  (ISO)
15-acetyldeoxynivalenol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
16,16-dimethylprostaglandin E2  (EXP,ISO)
17-hydroxyjolkinolide B  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2-(4-hydroxyphenyl)ethanol  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (ISO)
2-acetamidofluorene  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-acetyloxy-4-(trifluoromethyl)benzoic acid  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-Hydroxy-4-trifluoromethyl benzoic acid  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-Methoxy-4-methylphenol  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
22-Hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (EXP)
3',5'-di-O-methyltricetin  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dichloroaniline  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-acetyldeoxynivalenol  (ISO)
3-hydroxyphenylacetic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
3-phenylpropionic acid  (ISO)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-chlorobiphenyl  (ISO)
4-ethoxyaniline  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (EXP,ISO)
4-phenylbutyric acid  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-(N,N-hexamethylene)amiloride  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-oxoprostaglandin F1alpha  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7-NITROINDAZOLE  (EXP)
7alpha-hydroxycholesterol  (ISO)
8-Br-cAMP  (ISO)
8-epi-prostaglandin F2alpha  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
8-OH-DPAT  (ISO)
9,10-anthraquinone  (ISO)
9-(tetrahydrofuryl)adenine  (ISO)
9-cis-retinoic acid  (ISO)
9-Methoxycamptothecin  (ISO)
[6]-Shogaol  (ISO)
AACOCF3  (ISO)
acadesine  (ISO)
acenaphthoquinone  (ISO)
acetaldehyde  (ISO)
acetic acid  (EXP,ISO)
acetylsalicylic acid  (EXP,ISO)
Aciculatin  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
acteoside  (ISO)
actinomycin D  (EXP,ISO)
acyclovir  (ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
AH23848  (ISO)
AICA ribonucleotide  (ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (EXP)
alfacalcidol  (EXP)
aliskiren  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allantoin  (EXP)
allopurinol  (EXP)
allyl alcohol  (EXP)
Aloe emodin  (ISO)
alpha-Chaconine  (ISO)
alpha-D-galactose  (ISO)
alpha-linolenic acid  (EXP,ISO)
alpha-mangostin  (EXP)
alpha-methylhistamine  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (ISO)
Alternaramide  (ISO)
alternariol  (ISO)
aluminium atom  (ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (ISO)
amarogentin  (ISO)
amentoflavone  (ISO)
amikacin  (ISO)
amiloride  (EXP,ISO)
aminoguanidine  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
Ammothamnine  (ISO)
amodiaquine  (ISO)
amphetamine  (EXP)
amphibole asbestos  (EXP,ISO)
ampicillin  (EXP)
anandamide  (EXP,ISO)
Anemoside B4  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene-1,8,9-triol  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
arachidonic acid  (EXP,ISO)
Archazolid B  (ISO)
Arctiin  (ISO)
arecoline  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
asarone  (ISO)
asbestos  (ISO)
asiatic acid  (ISO)
astaxanthin  (EXP,ISO)
astilbin  (ISO)
atenolol  (ISO)
atorvastatin calcium  (EXP)
ATP  (ISO)
atrazine  (EXP,ISO)
atropine  (EXP)
auranofin  (ISO)
auraptene  (ISO)
aureusidin  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
baicalin  (EXP)
benfotiamine  (ISO)
benzalkonium chloride  (ISO)
benzamide  (EXP)
benzatropine  (ISO)
benzene  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoic acid  (ISO)
Benzoyl peroxide  (ISO)
Benzoylpaeoniflorin  (ISO)
berberine  (ISO)
Bergenin  (EXP)
beryllium sulfate  (ISO)
Besigomsin  (ISO)
beta-amyrin  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-ionone  (ISO)
beta-naphthoflavone  (EXP)
beta-tocopherol  (EXP)
betulinic acid  (EXP)
bicalutamide  (ISO)
bifenthrin  (EXP,ISO)
biochanin A  (ISO)
biphenyl-2,2'-diol  (ISO)
biphenyl-2-ol  (ISO)
biphenyl-4,4'-diol  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol A dimethacrylate  (ISO)
Bisphenol A glycidylmethacrylate  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bortezomib  (ISO)
Botulinum toxin type A  (EXP)
BQ 123  (EXP,ISO)
bromfenac  (ISO)
bromobenzene  (EXP)
brucine  (ISO)
bucladesine  (ISO)
budesonide  (EXP,ISO)
bufalin  (ISO)
bupivacaine  (ISO)
busulfan  (ISO)
butan-1-ol  (EXP,ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
Butralin  (EXP)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (ISO)
cannabidiol  (EXP,ISO)
cannabidiolic acid  (ISO)
capecitabine  (ISO)
capillarisin  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
captopril  (EXP)
carazolol  (ISO)
carbachol  (EXP)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (ISO)
carfilzomib  (ISO)
carnosic acid  (ISO)
carnosine  (ISO)
carrageenan  (EXP,ISO)
carvacrol  (EXP,ISO)
Cassiastearoptene  (EXP)
catalpol  (ISO)
CCCP  (ISO)
celastrol  (ISO)
celecoxib  (EXP,ISO)
cerium trichloride  (ISO)
ceruletide  (EXP)
cetylpyridinium  (ISO)
chaetoglobosin A  (ISO)
chenodeoxycholic acid  (ISO)
chloramphenicol  (ISO)
chlordecone  (ISO)
chlorobenzene  (ISO)
chlorogenic acid  (EXP,ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorphenamine  (ISO)
chlorpropham  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP,ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (ISO)
chrysin  (EXP,ISO)
chrysin 5,7-dimethyl ether  (EXP)
ciglitazone  (EXP,ISO)
cilostazol  (ISO)
cinaciguat  (EXP)
ciprofibrate  (ISO)
cirsilineol  (ISO)
Cirsimarin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
citronellol  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP)
cordycepin  (ISO)
corilagin  (ISO)
corn oil  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
cortisol  (EXP,ISO)
costunolide  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
cumene hydroperoxide  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (ISO)
cyprodinil  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
dapagliflozin  (EXP)
dapoxetine  (EXP)
DAPT  (ISO)
daunorubicin  (EXP)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
Decursin  (ISO)
deguelin  (ISO)
dehydroascorbic acid  (EXP)
dehydrocostus lactone  (ISO)
Dehydrodiisoeugenol  (ISO)
delta-tocopherol  (EXP)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
dextromethorphan  (ISO)
Diacetoxyscirpenol  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
dibenzofuran  (EXP)
dibenzoylmethane  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dieckol  (ISO)
dienogest  (ISO)
diethyl phthalate  (ISO)
Dihydrotanshinone I  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (EXP)
dimethoate  (EXP)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinic acid  (EXP)
dimethylarsinous acid  (ISO)
dioscin  (EXP)
diosgenin  (ISO)
diosmin  (EXP,ISO)
dioxygen  (EXP,ISO)
diphenhydramine  (ISO)
dipyridamole  (EXP,ISO)
diquat  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (EXP)
diuron  (ISO)
dizocilpine maleate  (ISO)
dobutamine  (ISO)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
DuP 697  (EXP,ISO)
edelfosine  (ISO)
elemental selenium  (EXP,ISO)
embelin  (ISO)
emodin  (EXP)
enalapril  (EXP,ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
enniatin  (ISO)
entacapone  (ISO)
entinostat  (ISO)
equol  (ISO)
erastin  (EXP,ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
eriodictyol  (ISO)
erlotinib hydrochloride  (ISO)
esmolol  (ISO)
ethanol  (EXP,ISO)
Ethyl pyruvate  (EXP,ISO)
ethylbenzene  (ISO)
ethylisopropylamiloride  (ISO)
etodolac  (EXP,ISO)
etoposide  (ISO)
etoricoxib  (EXP,ISO)
eugenol  (EXP,ISO)
eupatilin  (ISO)
everolimus  (EXP)
Evodiamine  (ISO)
famotidine  (EXP)
febuxostat  (EXP)
fenbendazole  (ISO)
fenhexamid  (ISO)
fenofibrate  (ISO)
ferric ammonium citrate  (ISO)
ferrosoferric oxide  (ISO)
ferrostatin-1  (EXP,ISO)
ferulic acid  (EXP,ISO)
Fexofenadine hydrochloride  (ISO)
finasteride  (EXP)
Flavokawain A  (ISO)
flavone  (ISO)
fludioxonil  (ISO)
fludrocortisone  (ISO)
flufenamic acid  (ISO)
fluoranthene  (ISO)
fluoxetine  (EXP)
flupenthixol  (ISO)
flurbiprofen  (EXP,ISO)
Fluridone  (ISO)
flutamide  (ISO)
fluvoxamine  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
Forsythiaside  (ISO)
Fraxinellone  (ISO)
fructose  (EXP)
fucoidan  (ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
Fulvic acid  (ISO)
furosemide  (EXP)
Fusarenone X  (ISO)
galactose  (ISO)
gallic acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP)
gamma-linolenic acid  (ISO)
gamma-tocopherol  (EXP,ISO)
Gastrodin  (ISO)
gefitinib  (ISO)
geldanamycin  (EXP)
gemcitabine  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (ISO)
genkwanin  (ISO)
gentamycin  (EXP)
geraniol  (EXP,ISO)
gingerol  (ISO)
ginsenoside C-K  (EXP,ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glyburide  (EXP)
glycidol  (EXP)
glycyrol  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP,ISO)
Goe 6976  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (EXP)
guaiacol  (ISO)
guggulsterone  (ISO)
GW 1929  (ISO)
GW 501516  (ISO)
haloperidol  (ISO)
halothane  (EXP)
harmaline  (ISO)
helenalin  (ISO)
helioxanthin  (ISO)
heparin  (EXP)
herbimycin  (EXP)
hesperetin  (EXP,ISO)
hesperidin  (EXP,ISO)
hexachlorobenzene  (ISO)
hexane  (ISO)
hinokiflavone  (ISO)
histamine  (EXP,ISO)
homocysteine  (ISO)
homoeriodictyol  (ISO)
Honokiol  (ISO)
hydrochlorothiazide  (EXP)
hydrogen chloride  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxytyrosol  (ISO)
Ibudilast  (EXP)
ibuprofen  (EXP,ISO)
icariin  (ISO)
icariside II  (ISO)
icatibant  (EXP)
ICI 118551  (ISO)
icosanoid  (ISO)
ifosfamide  (EXP)
iloprost  (ISO)
imidazoles  (ISO)
immunological adjuvant  (EXP)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
indoprofen  (ISO)
irbesartan  (EXP)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
iron(III) citrate  (ISO)
iron(III) nitrilotriacetate  (EXP)
isatin  (EXP)
isoflurane  (EXP)
isoliquiritigenin  (EXP,ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP,ISO)
isothiocyanate  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
JTE-013  (ISO)
juglone  (ISO)
kaempferol  (ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
kainic acid  (EXP,ISO)
kenpaullone  (EXP)
ketoconazole  (ISO)
ketoprofen  (ISO)
ketorolac  (EXP,ISO)
ketorolac tromethamine  (ISO)
KN-93  (ISO)
KT 5720  (ISO)
L-1,4-dithiothreitol  (ISO)
L-arginine  (EXP)
L-ascorbic acid  (EXP,ISO)
L-dehydroascorbic acid  (EXP)
L-gamma-glutamyl-L-cysteine  (ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
L-proline betaine  (ISO)
lansoprazole  (EXP)
lapatinib  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
Leonurine  (EXP)
levamisole  (ISO)
levofloxacin  (ISO)
Licarin A  (EXP)
lidocaine  (EXP)
linoleic acid  (EXP,ISO)
linuron  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lipoxin A4  (EXP)
liraglutide  (EXP)
lithium chloride  (EXP,ISO)
lithocholic acid  (ISO)
loganin  (ISO)
lonafarnib  (ISO)
lornoxicam  (ISO)
losartan  (EXP,ISO)
lovastatin  (EXP,ISO)
Lucidone  (ISO)
lumiracoxib  (ISO)
lupeol  (EXP)
lutein  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
lycorine  (ISO)
lysophosphatidylcholine  (EXP)
Malabaricone C  (ISO)
malaoxon  (ISO)
malathion  (ISO)
maleimides  (ISO)
mancozeb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
manoalide  (ISO)
maslinic acid  (ISO)
masoprocol  (ISO)
MC1568  (ISO)
mebendazole  (ISO)
mechlorethamine  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
melittin  (ISO)
meloxicam  (EXP,ISO)
melphalan  (ISO)
mercury dichloride  (EXP)
mesalamine  (EXP)
metaproterenol  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
Methanandamide  (ISO)
methanol  (ISO)
methiocarb  (ISO)
methotrexate  (EXP,ISO)
methoxamine  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methyltestosterone  (ISO)
metoprolol  (EXP,ISO)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
midostaurin  (EXP)
mifepristone  (EXP)
minocycline  (ISO)
miquelianin  (ISO)
misoprostol  (EXP)
mitomycin C  (ISO)
Mitotane  (ISO)
Mitragynine  (ISO)
MK-2206  (ISO)
Mofezolac (TN)  (EXP)
monascin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monotropein  (ISO)
montelukast  (ISO)
morin  (EXP)
morphine  (EXP,ISO)
Morroniside  (ISO)
morusin  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
myricitrin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP,ISO)
N(omega)-methyl-L-arginine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-feruloyltyramine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nabumetone  (EXP)
naphthalenes  (EXP,ISO)
naproxen  (EXP,ISO)
Narciclasine  (ISO)
naringin  (EXP,ISO)
nebivolol  (ISO)
Neferine  (EXP)
neoastilbin  (ISO)
neoechinulin A  (ISO)
neohesperidin dihydrochalcone  (ISO)
nerolidol  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nifedipine  (EXP,ISO)
Niflumic acid  (ISO)
nimesulide  (EXP,ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
nitroprusside  (ISO)
nomifensine  (ISO)
Nonylphenol  (EXP,ISO)
Nookatone  (EXP)
notoginsenoside R1  (ISO)
NS-398  (EXP,ISO)
o-anisidine  (ISO)
o-cresol  (EXP)
O-methylsalicylic acid  (ISO)
Obacunone  (ISO)
ochratoxin A  (ISO)
ofloxacin  (EXP)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleoyl ethanolamide  (ISO)
oleuropein  (EXP,ISO)
omeprazole  (EXP,ISO)
omethoate  (EXP)
orciprenaline  (ISO)
organoselenium compound  (EXP,ISO)
oridonin  (EXP)
orlistat  (ISO)
oroxylin A  (ISO)
ouabain  (EXP)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
oxybenzone  (ISO)
oxytocin  (EXP,ISO)
ozone  (EXP,ISO)
p-tolualdehyde  (ISO)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paeoniflorin  (ISO)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
paroxetine  (ISO)
parthenolide  (EXP,ISO)
patchouli alcohol  (EXP)
PCB138  (ISO)
pelargonidin  (ISO)
penbutolol  (ISO)
pentane-2,3-dione  (ISO)
Pentoxifylline  (EXP)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
PGI3  (ISO)
phenanthridone  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenylarsine oxide  (EXP,ISO)
phenylbutazone  (ISO)
phenylephrine  (EXP)
phenylhydrazine  (ISO)
phenytoin  (EXP)
PhIP  (ISO)
phloretic acid  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (EXP,ISO)
phosphatidic acid  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pinostrobin  (EXP)
pioglitazone  (EXP,ISO)
piperine  (ISO)
pipoxolan  (ISO)
pirimiphos-methyl  (ISO)
pirinixic acid  (ISO)
piroxicam  (EXP,ISO)
platinum  (ISO)
platinum(0)  (ISO)
platycodin D  (EXP,ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
poly(I:C)  (ISO)
poly(vinylpyrrolidone)  (EXP)
polymyxin B2  (ISO)
ponasterone A  (EXP)
potassium bromate  (ISO)
potassium chloride  (EXP)
potassium iodide  (ISO)
Pranoprofen  (ISO)
pravastatin  (EXP)
prednisolone  (ISO)
pristane  (ISO)
proanthocyanidin  (EXP)
procyclidine  (ISO)
prodigiosin  (EXP)
progesterone  (EXP,ISO)
propiconazole  (EXP)
propranolol  (ISO)
prostaglandin A1  (ISO)
prostaglandin D2  (ISO)
prostaglandin D3  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin E3  (ISO)
prostaglandin F1alpha  (ISO)
prostaglandin F2alpha  (EXP,ISO)
prostaglandin G2  (ISO)
prostaglandin I2  (EXP)
protein kinase inhibitor  (ISO)
protoporphyrin  (ISO)
protriptyline  (ISO)
prunetin  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
puromycin  (ISO)
pyrazines  (ISO)
pyrene  (ISO)
pyridoxamine  (ISO)
pyrimethanil  (ISO)
pyrogallol  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quercetin 3-sulfate  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP,ISO)
ramipril  (EXP)
ranitidine  (EXP)
reactive oxygen species  (EXP,ISO)
Rebamipide  (EXP)
rebaudioside A  (ISO)
reserpine  (EXP)
resolvin D1  (ISO)
resolvin D2  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
rimonabant  (ISO)
rivastigmine  (ISO)
Ro 31-8220  (ISO)
rofecoxib  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rubimaillin  (ISO)
rutin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salvianolic acid A  (ISO)
sarpogrelate  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SC-58125  (EXP,ISO)
scalaradial  (ISO)
scoparone  (ISO)
scopolamine  (ISO)
selenium atom  (EXP,ISO)
senecionine  (ISO)
Senkirkine  (ISO)
serotonin  (EXP,ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
Sesamol  (ISO)
sevoflurane  (EXP)
Shikonin  (ISO)
silibinin  (ISO)
silicon atom  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP,ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium aurothiomalate  (ISO)
sodium chloride  (EXP,ISO)
sodium chromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
sodium hydrogensulfite  (EXP,ISO)
Sodium salicylate  (ISO)
sodium sulfite  (EXP)
Soman  (EXP)
Sophocarpine  (ISO)
Sophoricoside  (ISO)
sorbinil  (ISO)
soyasaponin I  (ISO)
sphinganine 1-phosphate  (ISO)
sphingosine 1-phosphate  (ISO)
staurosporine  (ISO)
stavudine  (ISO)
sterigmatocystin  (EXP)
steviol  (ISO)
stevioside  (ISO)
stigmasterol  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
succimer  (ISO)
succinic acid  (ISO)
sucrose  (EXP)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (EXP,ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (EXP,ISO)
superoxide  (ISO)
suramin  (ISO)
Swertiamarin  (EXP)
syringic acid  (EXP)
T-2 toxin  (ISO)
tacrine  (EXP,ISO)
tacrolimus hydrate  (ISO)
taiwanin C  (ISO)
tamarixetin  (ISO)
tamoxifen  (ISO)
tangeretin  (EXP)
tannic acid  (EXP)
Tanshinone I  (ISO)
taurocholic acid  (ISO)
tebuconazole  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
TEMPO  (ISO)
tenofovir disoproxil fumarate  (EXP)
tephrosin  (ISO)
terameprocol  (ISO)
terephthalic acid  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetradecane  (EXP)
tetrahydrocurcumin  (ISO)
tetramethylpyrazine  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP,ISO)
thapsigargin  (ISO)
theaflavin  (ISO)
thiamethoxam  (ISO)
thiamine(1+) chloride  (EXP)
thioacetamide  (EXP,ISO)
thiocitrulline  (EXP)
thiophanate-methyl  (EXP)
thiourea  (ISO)
thiram  (ISO)
thromboxane A2  (ISO)
thromboxane B2  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
thyroxine  (EXP,ISO)
tienilic acid  (ISO)
titanium dioxide  (EXP,ISO)
tolcapone  (ISO)
toluene  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trans-piceid  (ISO)
trazodone  (EXP,ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Trihexyphenidyl  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
Tylophorine  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
undecane  (EXP)
uranium atom  (EXP)
urethane  (EXP,ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanadyl sulfate  (ISO)
vanillin  (ISO)
vemurafenib  (ISO)
venom  (ISO)
vincristine  (ISO)
vinorelbine  (ISO)
vinyl carbamate  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (ISO)
VX nerve agent  (EXP)
wedelolactone  (ISO)
withaferin A  (ISO)
wogonin  (ISO)
wortmannin  (ISO)
xanthohumol  (EXP,ISO)
yohimbine  (EXP)
zafirlukast  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zidovudine  (ISO)
zileuton  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IMP)
bone mineralization  (IMP)
brown fat cell differentiation  (ISO)
cellular oxidant detoxification  (IEA)
cellular response to ATP  (IEP)
cellular response to fluid shear stress  (ISO)
cellular response to heat  (IEP)
cellular response to homocysteine  (IEP)
cellular response to hypoxia  (ISO)
cellular response to lead ion  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to non-ionic osmotic stress  (ISO)
cellular response to organonitrogen compound  (IEP)
cyclooxygenase pathway  (IBA,ISO,ISS)
decidualization  (IMP,ISO)
embryo implantation  (IMP,ISO)
hair cycle  (IEP)
learning  (IMP)
maintenance of blood-brain barrier  (IMP)
memory  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of calcium ion transport  (IMP)
negative regulation of cell cycle  (IGI)
negative regulation of cell population proliferation  (IDA)
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  (ISO)
negative regulation of smooth muscle contraction  (IMP)
negative regulation of synaptic transmission, dopaminergic  (IMP)
positive regulation of apoptotic process  (IMP)
positive regulation of brown fat cell differentiation  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of fever generation  (IDA,ISO)
positive regulation of fibroblast growth factor production  (IMP)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of platelet-derived growth factor production  (IMP)
positive regulation of prostaglandin biosynthetic process  (ISO)
positive regulation of protein import into nucleus  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of smooth muscle contraction  (IMP)
positive regulation of synaptic plasticity  (IMP)
positive regulation of synaptic transmission, glutamatergic  (IMP)
positive regulation of transforming growth factor beta production  (IMP)
positive regulation of vascular endothelial growth factor production  (IMP)
positive regulation of vasoconstriction  (IMP)
prostaglandin biosynthetic process  (IMP,ISO)
prostaglandin secretion  (ISO)
regulation of blood pressure  (ISO,ISS)
regulation of cell population proliferation  (ISO)
regulation of neuroinflammatory response  (ISO,ISS)
response to angiotensin  (IEP)
response to cytokine  (IMP)
response to estradiol  (IEP)
response to fatty acid  (IEP)
response to fructose  (IEP)
response to glucocorticoid  (IEP)
response to lipopolysaccharide  (IMP)
response to manganese ion  (IEP)
response to nematode  (ISO)
response to organic cyclic compound  (IEP)
response to organic substance  (IEP)
response to organonitrogen compound  (IEP)
response to oxidative stress  (IEA)
response to tumor necrosis factor  (IEP)
response to vitamin D  (IEP)
response to xenobiotic stimulus  (IEP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (IEA,ISO)
celecoxib pharmacodynamics pathway  (ISO)
celecoxib pharmacokinetics pathway   (ISO)
cyclooxygenase mediated pathway of arachidonic acid metabolism  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
etoposide pharmacodynamics pathway  (ISO)
etoposide pharmacokinetics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacokinetics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
Leishmaniasis pathway  (IEA)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway   (ISO)
paracetamol drug pathway  (ISO)
piroxicam pharmacodynamics pathway  (ISO)
pro-inflammatory cytokine mediated pathway   (IDA)
prostanoid biosynthetic pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
small cell lung carcinoma pathway  (IEA)
sodium salicylate pharmacodynamics pathway  (ISO)
sphingosine 1-phosphate signaling pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway   (ISO)
vascular endothelial growth factor signaling pathway  (IEA)

References

References - curated
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37. COX-2, but not COX-1, activity is necessary for the induction of perforant path long-term potentiation and spatial learning in vivo. Cowley TR, etal., Eur J Neurosci. 2008 Jun;27(11):2999-3008. Epub 2008 Jun 6.
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41. Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma. Deininger MH and Schluesener HJ, J Neuroimmunol. 1999 Mar 1;95(1-2):202-8.
42. Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression. Deininger MH, etal., Brain Res. 2000 Dec 1;885(1):111-6.
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45. Protective effect of cyclooxygenase-2 (COX-2) inhibitors but not non-selective cyclooxygenase (COX)-inhibitors on ethanol withdrawal-induced behavioural changes. Dhir A, etal., Addict Biol. 2005 Dec;10(4):329-35.
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74. Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease. Hammes LS, etal., Gynecol Oncol. 2008 Jun 18.
75. Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease. Hammes LS, etal., Gynecol Oncol. 2008 Sep;110(3):445-51. Epub 2008 Jun 20.
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83. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Hildebrandt MA, etal., PLoS One. 2010 Aug 25;5(8):e12402.
84. Cyclooxygenase-dependent vasoconstricting factor(s) in remodelled rat femoral arteries. Hirao A, etal., Cardiovasc Res. 2008 Jul 1;79(1):161-8. Epub 2008 May 2.
85. Prostanoids as regulators of innate and adaptive immunity. Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3.
86. Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. Ho WS and Randall MD, Br J Pharmacol. 2007 Mar;150(5):641-51. Epub 2007 Jan 22.
87. Improvements of the algorithm for defining QRS onset and offset in the Pipberger program. Hobel W, etal., Adv Cardiol. 1978;21:181-4.
88. Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy. Holtman L, etal., Epilepsy Res. 2010 Sep;91(1):49-56.
89. Cyclo-oxygenases and prostaglandins in acute inflammatory demyelination of the peripheral nerve. Hu W, etal., Neurology. 2003 Dec 23;61(12):1774-9.
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238. [The effect of nitric oxide inhalation on the expression of COX-2 and toll-like receptor 4 in rat acute lung injury induced by lipopolysaccharide]. Wu YW, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2009 Feb;32(2):111-4.
239. A haplotype of cyclooxygenase-2 gene is associated with idiopathic pulmonary fibrosis. Xaubet A, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2010 Jul;27(2):121-30.
240. [Effect of letrozole on endometrosis and apoptosis of ectopic endometrial cells in rats]. Xia X, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Jan;38(1):54-9. doi: 10.3969/j.issn.1672-7347.2013.01.010.
241. Down-regulated CFTR During Aging Contributes to Benign Prostatic Hyperplasia. Xie C, etal., J Cell Physiol. 2015 Aug;230(8):1906-15. doi: 10.1002/jcp.24921.
242. [Association between single nucleotide polymorphisms in the promoter of cyclooxygenase COX-2 gene and hereditary susceptibility to pancreatic cancer]. Xu DK, etal., Zhonghua Yi Xue Za Zhi. 2008 Jul 22;88(28):1961-5.
243. Immediate-early MEK-1-dependent stabilization of rat smooth muscle cell cyclooxygenase-2 mRNA by Galpha(q)-coupled receptor signaling. Xu K, etal., J Biol Chem 2000 Jul 28;275(30):23012-9.
244. Expression pattern of cyclooxygenase-2 in normal rat epidermis and pilosebaceous unit during hair cycle. Xu Y, etal., Acta Histochem Cytochem. 2008 Dec 27;41(6):157-63. Epub 2008 Oct 28.
245. Involvement of hypothalamic cyclooxygenase-2, interleukin-1ß and melanocortin in the development of docetaxel-induced anorexia in rats. Yamamoto K, etal., Toxicology. 2012 Dec 16;302(2-3):190-6. doi: 10.1016/j.tox.2012.07.015. Epub 2012 Aug 4.
246. Profiling of genetic variations in inflammation pathway genes in relation to bladder cancer predisposition. Yang H, etal., Clin Cancer Res. 2008 Apr 1;14(7):2236-44.
247. A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2. Yeoh AS, etal., Mol Cancer Ther. 2007 Aug;6(8):2319-27.
248. The protective role of Kangen-karyu against fructose-induced metabolic syndrome in a rat model. Yokozawa T, etal., J Pharm Pharmacol. 2007 Sep;59(9):1271-8.
249. Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system. Yoshikawa K, etal., Brain Res. 2011 Jan 7;1367:22-32. doi: 10.1016/j.brainres.2010.10.019. Epub 2010 Oct 13.
250. Expression of cyclooxygenase-1 and -2 in human breast cancer. Yoshimura N, etal., Surg Today. 2003;33(11):805-11.
251. Prognostic value of cyclooxygenase-2 expression in squamous cell carcinoma of the bladder. Youssef RF, etal., J Urol. 2011 Mar;185(3):1112-7. Epub 2011 Jan 21.
252. The anti-inflammatory effect of celecoxib does not prevent liver fibrosis in bile duct-ligated rats. Yu J, etal., Liver Int. 2008 Apr 23.
253. Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1/cip-1 and p27kip-1. Zahner G, etal., J Biol Chem 2002 Mar 22;277(12):9763-71.
254. Correlation of microRNA-16, microRNA-21 and microRNA-101 expression with cyclooxygenase-2 expression and angiogenic factors in cirrhotic and noncirrhotic human hepatocellular carcinoma. Zeng W, etal., PLoS One. 2014 Apr 23;9(4):e95826. doi: 10.1371/journal.pone.0095826. eCollection 2014.
255. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
256. Cyclooxygenase 2 promotes parathyroid hyperplasia in ESRD. Zhang Q, etal., J Am Soc Nephrol. 2011 Apr;22(4):664-72. Epub 2011 Feb 18.
257. [The effect of nimesulide on learning and memory function after serve traumatic brain injury in rats]. Zhang T and Zhang YX, Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Jul;42(4):498-502.
258. Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. Zhang X, etal., Gastroenterology. 2005 Aug;129(2):565-76.
259. The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: Signaling pathway. Zhang XH, etal., Am J Physiol Heart Circ Physiol. 2007 Aug 31;.
260. Interaction of cyclooxygenase-2 variants and smoking in pancreatic cancer: a possible role of nucleophosmin. Zhao D, etal., Gastroenterology. 2009 May;136(5):1659-68.
261. Cyclooxygenase-2 expression during immortalization and breast cancer progression. Zhao X, etal., Cancer Res. 2008 Jan 15;68(2):467-75. doi: 10.1158/0008-5472.CAN-07-0782.
262. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Zheng L, etal., Biomed Pharmacother. 2018 Jan;97:481-488. doi: 10.1016/j.biopha.2017.10.153. Epub 2017 Nov 6.
Additional References at PubMed
PMID:1380156   PMID:1419907   PMID:1556140   PMID:7592599   PMID:7947975   PMID:8352945   PMID:8945508   PMID:9545330   PMID:10385625   PMID:10783317   PMID:10987272   PMID:11245490  
PMID:11809702   PMID:11849824   PMID:11961302   PMID:12021206   PMID:12050186   PMID:12093889   PMID:12160205   PMID:12167602   PMID:12185016   PMID:12355421   PMID:12388434   PMID:12388444  
PMID:12408753   PMID:12429553   PMID:12429810   PMID:12431630   PMID:12452059   PMID:12467530   PMID:12478407   PMID:12511556   PMID:12560203   PMID:12576462   PMID:12621123   PMID:12664616  
PMID:12724285   PMID:12735864   PMID:12749384   PMID:12751753   PMID:12761246   PMID:12811798   PMID:12821538   PMID:12835322   PMID:12839936   PMID:12851252   PMID:12855701   PMID:12871573  
PMID:12882915   PMID:12888618   PMID:12900348   PMID:12912810   PMID:12918117   PMID:12925531   PMID:13129852   PMID:14499419   PMID:14530261   PMID:14613912   PMID:14633140   PMID:14643175  
PMID:14684367   PMID:14684611   PMID:15026129   PMID:15028765   PMID:15033806   PMID:15094475   PMID:15158123   PMID:15182944   PMID:15210717   PMID:15237442   PMID:15340111   PMID:15465891  
PMID:15471850   PMID:15501196   PMID:15525649   PMID:15525691   PMID:15526382   PMID:15548426   PMID:15550559   PMID:15569325   PMID:15613619   PMID:15633603   PMID:15644490   PMID:15681847  
PMID:15685372   PMID:15713628   PMID:15778400   PMID:15795519   PMID:15800925   PMID:15808647   PMID:15838313   PMID:15854663   PMID:15856452   PMID:15917189   PMID:15935072   PMID:15964853  
PMID:15979590   PMID:16002525   PMID:16008526   PMID:16083499   PMID:16110275   PMID:16140209   PMID:16189289   PMID:16221213   PMID:16323955   PMID:16339820   PMID:16357083   PMID:16373578  
PMID:16393343   PMID:16413500   PMID:16427196   PMID:16492981   PMID:16499924   PMID:16513083   PMID:16514433   PMID:16546299   PMID:16552365   PMID:16567054   PMID:16568149   PMID:16569634  
PMID:16572115   PMID:16597606   PMID:16603590   PMID:16619262   PMID:16622181   PMID:16622306   PMID:16644518   PMID:16646980   PMID:16721810   PMID:16777990   PMID:16780881   PMID:16804969  
PMID:16809483   PMID:16820795   PMID:16837093   PMID:16837651   PMID:16893539   PMID:16935468   PMID:16935907   PMID:16995982   PMID:17043228   PMID:17061049   PMID:17084486   PMID:17175107  
PMID:17196338   PMID:17221297   PMID:17234889   PMID:17244895   PMID:17307294   PMID:17318410   PMID:17382352   PMID:17441341   PMID:17505916   PMID:17511027   PMID:17537839   PMID:17539917  
PMID:17560944   PMID:17581922   PMID:17607546   PMID:17615156   PMID:17622965   PMID:17634395   PMID:17669705   PMID:17704286   PMID:17716650   PMID:17763946   PMID:17766473   PMID:17855367  
PMID:17901979   PMID:17916350   PMID:17929312   PMID:17959708   PMID:17962899   PMID:17977909   PMID:17984113   PMID:18028778   PMID:18034350   PMID:18079588   PMID:18094072   PMID:18095163  
PMID:18218685   PMID:18292448   PMID:18297109   PMID:18335410   PMID:18344592   PMID:18414395   PMID:18452714   PMID:18515110   PMID:18534982   PMID:18543083   PMID:18621015   PMID:18650268  
PMID:18684886   PMID:18688715   PMID:18707853   PMID:18714024   PMID:18723875   PMID:18786748   PMID:18814970   PMID:18843091   PMID:18946499   PMID:18992713   PMID:19037103   PMID:19056763  
PMID:19141058   PMID:19144694   PMID:19145780   PMID:19155631   PMID:19184357   PMID:19233864   PMID:19239908   PMID:19246637   PMID:19247274   PMID:19327173   PMID:19356723   PMID:19383433  
PMID:19444941   PMID:19449290   PMID:19467272   PMID:19483106   PMID:19505386   PMID:19515980   PMID:19591013   PMID:19609832   PMID:19625688   PMID:19628672   PMID:19632905   PMID:19657099  
PMID:19679653   PMID:19723084   PMID:19764341   PMID:19846045   PMID:19861503   PMID:19912740   PMID:19937640   PMID:19959193   PMID:20032084   PMID:20083630   PMID:20091889   PMID:20134354  
PMID:20219444   PMID:20333648   PMID:20411591   PMID:20448152   PMID:20534845   PMID:20549385   PMID:20607198   PMID:20610829   PMID:20735829   PMID:20814068   PMID:20826536   PMID:20977452  
PMID:21038659   PMID:21066890   PMID:21164135   PMID:21186597   PMID:21192429   PMID:21239635   PMID:21262218   PMID:21296955   PMID:21323895   PMID:21355315   PMID:21394197   PMID:21402727  
PMID:21428715   PMID:21506880   PMID:21526453   PMID:21584750   PMID:21609430   PMID:21613413   PMID:21640730   PMID:21679927   PMID:21688048   PMID:21716255   PMID:21802455   PMID:21812273  
PMID:21856910   PMID:21885043   PMID:21932136   PMID:21951274   PMID:21999702   PMID:22142485   PMID:22174936   PMID:22219191   PMID:22387750   PMID:22446402   PMID:22489918   PMID:22523381  
PMID:22564588   PMID:22575043   PMID:22579820   PMID:22613973   PMID:22617488   PMID:22767315   PMID:22791338   PMID:22822059   PMID:22859375   PMID:22898625   PMID:22932114   PMID:22941198  
PMID:23002358   PMID:23034271   PMID:23240616   PMID:23254481   PMID:23306170   PMID:23388481   PMID:23401543   PMID:23423254   PMID:23429494   PMID:23458502   PMID:23515587   PMID:23587942  
PMID:23609497   PMID:23859035   PMID:23877023   PMID:23973752   PMID:23975340   PMID:24064301   PMID:24089527   PMID:24136226   PMID:24210203   PMID:24226522   PMID:24260171   PMID:24260743  
PMID:24291639   PMID:24354410   PMID:24462674   PMID:24559584   PMID:24614038   PMID:24740788   PMID:24773364   PMID:24796880   PMID:24815169   PMID:24841674   PMID:24914375   PMID:25058273  
PMID:25070591   PMID:25080527   PMID:25123248   PMID:25143455   PMID:25216050   PMID:25303727   PMID:25388440   PMID:25400168   PMID:25506925   PMID:25542758   PMID:25635769   PMID:25648833  
PMID:25700020   PMID:25736434   PMID:25811420   PMID:25841778   PMID:25846103   PMID:25989136   PMID:26009769   PMID:26123748   PMID:26241029   PMID:26276312   PMID:26335727   PMID:26466383  
PMID:26514267   PMID:26543049   PMID:26610611   PMID:26612417   PMID:26685759   PMID:26724476   PMID:26824492   PMID:27178425   PMID:27580512   PMID:27642067   PMID:27686454   PMID:27874832  
PMID:27923787   PMID:28352129   PMID:28451639   PMID:28508833   PMID:28642034   PMID:28642262   PMID:28688903   PMID:28770648   PMID:28797762   PMID:28826906   PMID:28933223   PMID:29073723  
PMID:29436670   PMID:29580751   PMID:29614314   PMID:29662056   PMID:29700115   PMID:30292829   PMID:30736955   PMID:30778877   PMID:30794693   PMID:30938133   PMID:31380437   PMID:31622656  
PMID:32204021   PMID:32311346   PMID:32799674   PMID:32909857   PMID:34428744   PMID:34610503   PMID:34841988   PMID:35172004   PMID:35396693   PMID:35537317   PMID:35969208   PMID:36189462  
PMID:36586043   PMID:36768450   PMID:37059378   PMID:37562566   PMID:38286397  


Genomics

Comparative Map Data
Ptgs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,714,063 - 64,722,320 (+)NCBIGRCr8
mRatBN7.21362,163,936 - 62,172,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1362,163,932 - 62,172,188 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1364,798,537 - 64,804,239 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01366,083,346 - 66,089,057 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,344,882 - 63,350,588 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,351,230 - 67,356,920 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,351,087 - 67,359,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,315,959 - 72,324,483 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,427,288 - 64,432,978 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11364,441,245 - 64,449,480 (+)NCBI
Celera1362,129,439 - 62,135,131 (+)NCBICelera
Cytogenetic Map13q21NCBI
PTGS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,671,791 - 186,680,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,671,791 - 186,680,922 (-)EnsemblGRCh38hg38GRCh38
GRCh371186,640,923 - 186,649,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361184,907,592 - 184,916,179 (-)NCBINCBI36Build 36hg18NCBI36
Build 341183,372,625 - 183,381,213NCBI
Celera1159,751,694 - 159,760,309 (-)NCBICelera
Cytogenetic Map1q31.1NCBI
HuRef1157,875,712 - 157,884,327 (-)NCBIHuRef
CHM1_11188,062,673 - 188,071,288 (-)NCBICHM1_1
T2T-CHM13v2.01186,026,616 - 186,035,248 (-)NCBIT2T-CHM13v2.0
Ptgs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,975,851 - 149,983,978 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,975,782 - 149,983,978 (+)EnsemblGRCm39 Ensembl
GRCm381150,100,031 - 150,108,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,100,031 - 150,108,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv371151,947,254 - 151,955,147 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361151,862,342 - 151,870,235 (+)NCBIMGSCv36mm8
Celera1152,546,728 - 152,554,611 (+)NCBICelera
Cytogenetic Map1G1NCBI
cM Map163.84NCBI
Ptgs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540625,079,945 - 25,086,171 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540625,077,988 - 25,086,259 (-)NCBIChiLan1.0ChiLan1.0
PTGS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2163,030,462 - 63,041,820 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1162,713,923 - 62,723,110 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,205,534 - 162,214,130 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,355,845 - 166,364,517 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,355,845 - 166,364,519 (-)Ensemblpanpan1.1panPan2
PTGS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1719,668,079 - 19,674,903 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl719,668,082 - 19,674,903 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha719,190,741 - 19,197,565 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0719,405,501 - 19,412,325 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl719,405,504 - 19,412,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1719,311,510 - 19,318,356 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0719,420,827 - 19,427,651 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0719,552,954 - 19,559,778 (-)NCBIUU_Cfam_GSD_1.0
Ptgs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934485,975,505 - 85,982,237 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364813,821,564 - 3,828,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9127,850,015 - 127,858,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19127,850,164 - 127,858,866 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29140,251,667 - 140,260,362 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12542,733,535 - 42,742,463 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2542,734,771 - 42,742,429 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605543,903,786 - 43,913,892 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248146,897,857 - 6,903,728 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248146,897,818 - 6,904,890 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptgs2
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:92
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000003567
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
2303028Bp329Blood pressure QTL 329arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135849787273485113Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat

Markers in Region
Ptgs2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21362,167,881 - 62,168,027 (+)MAPPERmRatBN7.2
Rnor_6.01367,355,032 - 67,355,177NCBIRnor6.0
Rnor_5.01372,320,172 - 72,320,317UniSTSRnor5.0
RGSC_v3.41364,431,090 - 64,431,235UniSTSRGSC3.4
Celera1362,133,243 - 62,133,388UniSTS
Cytogenetic Map13q21UniSTS
PMC27868P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21362,168,413 - 62,169,075 (+)MAPPERmRatBN7.2
Rnor_6.01367,355,564 - 67,356,225NCBIRnor6.0
Rnor_5.01372,320,704 - 72,321,365UniSTSRnor5.0
RGSC_v3.41364,431,622 - 64,432,283UniSTSRGSC3.4
Celera1362,133,775 - 62,134,436UniSTS
Cytogenetic Map13q21UniSTS
Ptgs2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21362,168,415 - 62,169,644 (+)MAPPERmRatBN7.2
Rnor_6.01367,355,566 - 67,356,794NCBIRnor6.0
Rnor_5.01372,320,706 - 72,321,934UniSTSRnor5.0
RGSC_v3.41364,431,624 - 64,432,852UniSTSRGSC3.4
Celera1362,133,777 - 62,135,005UniSTS
Cytogenetic Map13q21UniSTS


Genetic Models
This gene Ptgs2 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 11 12 3
Low 3 26 23 8 15 8 2 2 47 23 34 11 2
Below cutoff 16 33 32 4 32 6 8 16 4 6

Sequence


RefSeq Acc Id: ENSRNOT00000003567   ⟹   ENSRNOP00000003567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1362,163,932 - 62,172,188 (+)Ensembl
Rnor_6.0 Ensembl1367,351,087 - 67,359,335 (+)Ensembl
RefSeq Acc Id: NM_017232   ⟹   NP_058928
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81364,714,063 - 64,722,320 (+)NCBI
mRatBN7.21362,163,936 - 62,172,193 (+)NCBI
Rnor_6.01367,351,230 - 67,356,920 (+)NCBI
Rnor_5.01372,315,959 - 72,324,483 (+)NCBI
RGSC_v3.41364,427,288 - 64,432,978 (+)RGD
Celera1362,129,439 - 62,135,131 (+)RGD
Sequence:
RefSeq Acc Id: NP_058928   ⟸   NM_017232
- Peptide Label: precursor
- UniProtKB: Q64379 (UniProtKB/Swiss-Prot),   Q925V4 (UniProtKB/Swiss-Prot),   P35355 (UniProtKB/Swiss-Prot),   A6ICR0 (UniProtKB/TrEMBL),   Q63124 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003567   ⟸   ENSRNOT00000003567
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35355-F1-model_v2 AlphaFold P35355 1-604 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698878
Promoter ID:EPDNEW_R9403
Type:single initiation site
Name:Ptgs2_1
Description:prostaglandin-endoperoxide synthase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01367,351,086 - 67,351,146EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620349 AgrOrtholog
BioCyc Gene G2FUF-17948 BioCyc
BioCyc Pathway PWY66-374 [C20 prostanoid biosynthesis] BioCyc
BioCyc Pathway Image PWY66-374 BioCyc
Ensembl Genes ENSRNOG00000002525 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055018563 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003567 ENTREZGENE
  ENSRNOT00000003567.5 UniProtKB/Swiss-Prot
  ENSRNOT00055031581 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29527 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29527 ENTREZGENE
PANTHER PROSTAGLANDIN G/H SYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11903:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PTGS2 RGD
PhenoGen Ptgs2 PhenoGen
PRINTS ANPEROXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEROXIDASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002525 RatGTEx
  ENSRNOG00055018563 RatGTEx
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8A1UB91_RAT UniProtKB/TrEMBL
  A6ICR0 ENTREZGENE, UniProtKB/TrEMBL
  A6ICR1_RAT UniProtKB/TrEMBL
  P35355 ENTREZGENE, UniProtKB/Swiss-Prot
  Q63124 ENTREZGENE, UniProtKB/TrEMBL
  Q64379 ENTREZGENE
  Q925V4 ENTREZGENE
UniProt Secondary Q64379 UniProtKB/Swiss-Prot
  Q925V4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Ptgs2  prostaglandin-endoperoxide synthase 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ptgs2  prostaglandin-endoperoxide synthase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
null catalyzes the generation of prostaglandins from arachidonic acids  
null catalyzes the generation of prostaglandins from arachidonic acids 628427
gene_disease highly expressed in neurodegenerative disorders 625680
gene_drugs ketorolac, a water-soluble and nonselective inhibitor blocks the enzyme activity, but it can increase gene expression in cells of the blood-brain barrier 625680
gene_expression expressed in kidney 70545
gene_expression expressed in specialized tissues like ovarian granulosa cells, macrophages, endothelium, and seimnal vesicles; developmentally regulated expression pattern 625680
gene_function catalyzes conversion of arachidonic acid to prostaglandin H2 625680
gene_function acts both as a deoxygenase and peroxidase 625680
gene_process may function in the metabolism of arachidonic acid into prostanoids 70545
gene_process has a role in renal salt and water excretion 70545
gene_process major medaitor of inflammatory responses 625680
gene_process major medaitor of inflammatory responses 628427
gene_process may be a cytokine regulator in Leydig progenitor cells 625680
gene_process key enzyme in prostaglandin biosynthesis 625680
gene_regulation expression in the juxtaglomerular apparatus during low-salt diet is greatly reduced by a direct feedback inhibition through ANG II 625680
gene_regulation mRNA and protein expressions increases in alpha-beta-methyleneATP-induced gliosis and is dependent on ERK1/2 but independent of calcium signaling 625680
gene_regulation induced by interleukin 1 beta in Leydig cells 625680