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Gene: Ptgs2 (prostaglandin-endoperoxide synthase 2) Rattus norvegicus
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
RGD ID: 620349
Description: Exhibits oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and positive regulation of cytokine production. Localizes to cytoplasm and protein-containing complex. Colocalizes with caveola. Used to study several diseases, including Barrett's esophagus; brain disease (multiple); hypertension (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including carcinoma (multiple); glioblastoma multiforme (multiple); inflammatory bowel disease (multiple); pleurisy; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); avian influenza; liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (+)-alpha-tocopherol; (+)-pilocarpine; (-)-epigallocatechin 3-gallate.
Type: protein-coding
Also known as: COX-2; Cox2; cyclooxygenase 2; cyclooxygenase-2; PGH synthase 2; PGHS-2; PHS II; prostaglandin G/H synthase 2; prostaglandin H2 synthase 2
Homo sapiens (human) : PTGS2 (prostaglandin-endoperoxide synthase 2)  HGNC  Alliance
Mus musculus (house mouse) : Ptgs2 (prostaglandin-endoperoxide synthase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptgs2 (prostaglandin-endoperoxide synthase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PTGS2 (prostaglandin-endoperoxide synthase 2)
Canis lupus familiaris (dog) : PTGS2 (prostaglandin-endoperoxide synthase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptgs2 (prostaglandin-endoperoxide synthase 2)
Sus scrofa (pig) : PTGS2 (prostaglandin-endoperoxide synthase 2)
Chlorocebus sabaeus (African green monkey) : PTGS2 (prostaglandin-endoperoxide synthase 2)
Heterocephalus glaber (naked mole-rat) : Ptgs2 (prostaglandin-endoperoxide synthase 2)
more info ...
Allele / Splice: Ptgs2em1Mcwi   Ptgs2em2Mcwi  
Genetic Models: SS-Ptgs2em1Mcwi SS-Ptgs2em2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01367,351,230 - 67,356,920 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,351,087 - 67,359,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,315,959 - 72,324,483 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,427,288 - 64,432,978 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11364,441,245 - 64,449,480 (+)NCBI
Celera1362,129,439 - 62,135,131 (+)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)