Ptgs2 (prostaglandin-endoperoxide synthase 2) - Rat Genome Database

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Gene: Ptgs2 (prostaglandin-endoperoxide synthase 2) Rattus norvegicus
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
RGD ID: 620349
Description: Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and positive regulation of cytokine production. Acts upstream of or within bone mineralization. Located in cytoplasm. Part of protein-containing complex. Colocalizes with caveola. Used to study several diseases, including brain disease (multiple); hypertension (multiple); liver disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including carcinoma (multiple); glioblastoma (multiple); inflammatory bowel disease (multiple); pleurisy; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); avian influenza; liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (1->4)-beta-D-glucan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: COX-2; Cox2; cyclooxygenase 2; cyclooxygenase-2; PGH synthase 2; PGHS-2; PHS II; prostaglandin G/H synthase 2; prostaglandin H2 synthase 2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Ptgs2em1Mcwi   Ptgs2em2Mcwi  
Genetic Models: SS-Ptgs2em1Mcwi SS-Ptgs2em2Mcwi
Candidate Gene For: Bp329
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81364,714,063 - 64,722,320 (+)NCBIGRCr8
mRatBN7.21362,163,936 - 62,172,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1362,163,932 - 62,172,188 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1364,798,537 - 64,804,239 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01366,083,346 - 66,089,057 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,344,882 - 63,350,588 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,351,230 - 67,356,920 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,351,087 - 67,359,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,315,959 - 72,324,483 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,427,288 - 64,432,978 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11364,441,245 - 64,449,480 (+)NCBI
Celera1362,129,439 - 62,135,131 (+)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)