Ptgs2 (prostaglandin-endoperoxide synthase 2)

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Gene: Ptgs2 (prostaglandin-endoperoxide synthase 2) Rattus norvegicus

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Symbol:

Ptgs2

Name:

prostaglandin-endoperoxide synthase 2

RGD ID:

620349

Description:

Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and positive regulation of cytokine production. Acts upstream of or within bone mineralization. Located in cytoplasm. Part of protein-containing complex. Colocalizes with caveola. Used to study several diseases, including Barrett's esophagus; brain disease (multiple); hypertension (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including carcinoma (multiple); glioblastoma (multiple); inflammatory bowel disease (multiple); pleurisy; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); avian influenza; cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (1->4)-beta-D-glucan.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

COX-2; Cox2; cyclooxygenase 2; cyclooxygenase-2; PGH synthase 2; PGHS-2; PHS II; prostaglandin G/H synthase 2; prostaglandin H2 synthase 2

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Allele / Splice:

Ptgs2^em1Mcwi Ptgs2^em2Mcwi

Genetic Models:

SS-Ptgs2^em1Mcwi SS-Ptgs2^em2Mcwi

Candidate Gene For:

Bp329

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	13	62,164,080 - 62,169,770 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	62,163,932 - 62,172,188 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	64,798,537 - 64,804,239 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	13	66,083,346 - 66,089,057 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	13	63,344,882 - 63,350,588 (+)	NCBI	Rnor_WKY
Rnor_6.0	13	67,351,230 - 67,356,920 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	67,351,087 - 67,359,335 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	72,315,959 - 72,324,483 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	64,427,288 - 64,432,978 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	64,441,245 - 64,449,480 (+)	NCBI
Celera	13	62,129,439 - 62,135,131 (+)	NCBI		Celera
Cytogenetic Map	13	q21	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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