Ptgs2 (prostaglandin-endoperoxide synthase 2) - Rat Genome Database

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Gene: Ptgs2 (prostaglandin-endoperoxide synthase 2) Rattus norvegicus
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Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
RGD ID: 620349
Description: Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and positive regulation of cytokine production. Acts upstream of or within bone mineralization. Located in caveola and cytoplasm. Part of protein-containing complex. Used to study several diseases, including brain disease (multiple); hypertension (multiple); liver disease (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including carcinoma (multiple); glioblastoma (multiple); inflammatory bowel disease (multiple); pleurisy; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); avian influenza; cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (1->4)-beta-D-glucan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: COX-2; Cox2; cyclooxygenase 2; cyclooxygenase-2; PGH synthase 2; PGHS-2; Pghs2; PHS II; prostaglandin G/H synthase 2; prostaglandin H2 synthase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Ptgs2em1Mcwi ; Ptgs2em2Mcwi
Genetic Models: SS-Ptgs2em1Mcwi ; SS-Ptgs2em2Mcwi
Candidate Gene For: Bp329
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,714,063 - 64,722,320 (+)NCBIGRCr8
mRatBN7.21362,163,936 - 62,172,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1362,163,932 - 62,172,188 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1364,798,537 - 64,804,239 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01366,083,346 - 66,089,057 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,344,882 - 63,350,588 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,351,230 - 67,356,920 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,351,087 - 67,359,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,315,959 - 72,324,483 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,427,288 - 64,432,978 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11364,441,245 - 64,449,480 (+)NCBI
Celera1362,129,439 - 62,135,131 (+)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acute kidney failure  (IMP)
Acute Liver Failure  (IMP,ISO)
Acute Lung Injury  (IEP,ISO)
adenocarcinoma  (IMP,ISO)
Adrenal Gland Neoplasms  (ISO)
Albuminuria  (ISO)
Alcohol Withdrawal Delirium  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (IMP,ISO)
amyotrophic lateral sclerosis  (ISO)
Anaphylaxis  (IMP,ISO)
Anorexia  (IMP)
arteriosclerosis  (ISO)
asphyxia neonatorum  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (IEP,ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
avian influenza  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
B-cell lymphoma  (ISO)
Barrett's esophagus  (IMP,ISO)
bipolar disorder  (ISO)
bladder neck obstruction  (ISO)
Bone Fractures  (IMP)
Bone Neoplasms  (ISO)
Brain Injuries  (IMP,ISO)
brain ischemia  (IDA,IEP,ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cachexia  (ISO)
Calcification of Aortic Valve  (ISO)
carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
cardiomyopathy  (ISO)
cardiovascular system disease  (ISO)
Cerebral Hemorrhage  (IEP,ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
cognitive disorder  (ISO)
colitis  (IEP,ISO)
Colonic Neoplasms  (IMP,ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Cough  (ISO)
COVID-19  (ISO)
Creutzfeldt-Jakob disease  (ISO)
Crohn's disease  (IEP)
cryptorchidism  (ISO)
cystic fibrosis  (ISO)
cystitis  (IMP)
demyelinating disease  (ISO)
depressive disorder  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (IMP)
diabetic neuropathy  (IEP,IMP)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
ductal carcinoma in situ  (ISO)
duodenal ulcer  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (IDA,IMP,ISO)
Endotoxemia  (IEP)
Esophageal Neoplasms  (IEP,ISO)
esophagitis  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (IEP,IMP,ISO)
Experimental Autoimmune Encephalomyelitis  (IEP,ISO)
Experimental Autoimmune Neuritis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (IEP,IMP,ISO)
Experimental Radiation Injuries  (IEP)
Experimental Seizures  (IEP)
familial adenomatous polyposis  (ISO)
Fetal Growth Retardation  (IEP)
Fever  (IMP,ISO)
Fibrosis  (IMP,ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (IMP,ISO)
gastritis  (IMP)
gastroesophageal reflux disease  (ISO)
gastrointestinal stromal tumor  (ISO)
glioblastoma  (IEP,ISO)
gliosarcoma  (IEP)
granulosa cell tumor  (ISO)
Graves ophthalmopathy  (ISO)
growth hormone secreting pituitary adenoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (IEP)
Human Influenza  (ISO)
Huntington's disease  (IMP)
hydronephrosis  (ISO)
Hyperalgesia  (IMP,ISO)
Hyperemia  (ISO)
hyperglycemia  (ISO)
Hyperplasia  (ISO)
hypertension  (IAGP,ISO)
Hypoxia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
in situ carcinoma  (ISO)
Inflammation  (IMP,ISO)
inflammatory bowel disease  (ISO)
intestinal obstruction  (IEP)
Intestinal Polyps  (ISO)
invasive ductal carcinoma  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Laryngeal Neoplasms  (ISO)
Laryngeal Papillomatosis  (ISO)
Left Ventricular Hypertrophy  (IMP)
leiomyosarcoma  (ISO)
liver cirrhosis  (ISO)
lung cancer  (IMP)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
melanoma  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (IEP)
mouth disease  (ISO)
Mouth Neoplasms  (IMP,ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IMP)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (IMP,ISO)
Neoplasm Recurrence, Local  (ISO)
nephroblastoma  (ISO)
nephrotic syndrome  (IMP)
nervous system disease  (ISO)
Neurogenic Inflammation  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
occupational asthma  (ISO)
open-angle glaucoma  (ISO)
oral mucosa leukoplakia  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (IEP,IMP,ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
papilloma  (ISO)
parathyroid carcinoma  (ISO)
Parkinsonism  (IDA,ISO)
pericardial effusion  (ISO)
Peripheral Nerve Injuries  (IEP,ISO)
pleurisy  (IDA,IEP)
polycystic kidney disease  (IMP)
portal hypertension  (IMP)
pre-malignant neoplasm  (ISO)
Precocious Puberty  (ISO)
Premature Birth  (ISO)
prolactinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (IEP)
proteinuria  (ISO)
pulmonary emphysema  (IMP)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (IMP,ISO)
renal cell carcinoma  (IEP,ISO)
Reperfusion Injury  (IDA,IEP,IMP,ISO)
retrograde amnesia  (IMP)
rheumatoid arthritis  (ISO)
sarcoidosis  (ISO)
schizophrenia  (IEP)
secondary hyperparathyroidism  (IMP,ISO)
Sepsis-Associated Encephalopathy  (IEP)
skin disease  (ISO)
Skin Neoplasms  (ISO)
Sleep Deprivation  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (ISO)
status epilepticus  (IMP,ISO)
steatotic liver disease  (IMP)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombosis  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
traumatic brain injury  (ISO)
type 2 diabetes mellitus  (IEP)
ulcerative colitis  (IMP)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
Uterine Cervical Neoplasms  (ISO)
Ventilator-Induced Lung Injury  (IMP)
Wernicke encephalopathy  (IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(+)-isolariciresinol  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-pinoresinol  (ISO)
(+)-syringaresinol  (ISO)
(+)-syringaresinol beta-D-glucoside  (ISO)
(+)-taxifolin  (ISO)
(-)-Arctigenin  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (EXP)
(1S)-bornane-2,3-dione  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid  (EXP)
(E)-thiamethoxam  (ISO)
(R)-adrenaline  (ISO)
(R)-amygdalin  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (EXP,ISO)
1,2,4-trimethylbenzene  (EXP,ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,2-dioctanoyl-sn-glycero-3-phosphate  (ISO)
1,2-naphthoquinone  (ISO)
1,3,5-trinitrobenzene  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-hydroxy-2-naphthoic acid  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-methylnicotinamide  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (ISO)
1-Phenyl-6,7-dihydroxy-isochroman  (ISO)
11-deoxycorticosterone  (EXP)
11-deoxyprostaglandin E1  (ISO)
12(S)-HPETE  (ISO)
15-acetyldeoxynivalenol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
16,16-dimethylprostaglandin E2  (EXP,ISO)
17-hydroxyjolkinolide B  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2-(4-hydroxyphenyl)ethanol  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (ISO)
2-acetamidofluorene  (EXP)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-acetyloxy-4-(trifluoromethyl)benzoic acid  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminobiphenyl  (ISO)
2-arachidonoylglycerol  (ISO)
2-butoxyethanol  (ISO)
2-hydroxy-17beta-estradiol  (ISO)
2-Hydroxy-4-trifluoromethyl benzoic acid  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-Methoxy-4-methylphenol  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
22-Hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (EXP)
3',5'-di-O-methyltricetin  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-diindolylmethane  (EXP,ISO)
3,4-dichloroaniline  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-acetyldeoxynivalenol  (ISO)
3-hydroxyphenylacetic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methoxycatechol  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (EXP,ISO)
3-methylcholanthrene  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
3-phenylpropionic acid  (ISO)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-chlorobiphenyl  (ISO)
4-ethoxyaniline  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (EXP,ISO)
4-phenylbutyric acid  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-(N,N-hexamethylene)amiloride  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-Methoxyflavone  (ISO)
6-oxoprostaglandin F1alpha  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7-nitroindazole  (EXP)
7alpha-hydroxycholesterol  (ISO)
8-Br-cAMP  (ISO)
8-epi-prostaglandin F2alpha  (ISO)
8-hydroxy-2'-deoxyguanosine  (ISO)
8-OH-DPAT  (ISO)
9,10-anthraquinone  (ISO)
9-(tetrahydrofuryl)adenine  (ISO)
9-cis-retinoic acid  (ISO)
9-Methoxycamptothecin  (ISO)
[6]-Shogaol  (ISO)
AACOCF3  (ISO)
acadesine  (ISO)
acenaphthoquinone  (ISO)
acetaldehyde  (ISO)
acetic acid  (EXP,ISO)
acetylsalicylic acid  (EXP,ISO)
Aciculatin  (ISO)
acrolein  (ISO)
acrylamide  (EXP,ISO)
acteoside  (ISO)
actinomycin D  (EXP,ISO)
acyclovir  (ISO)
aflatoxin B1  (ISO)
Aflatoxin G1  (ISO)
AH23848  (ISO)
AICA ribonucleotide  (ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (EXP)
alfacalcidol  (EXP)
aliskiren  (EXP)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
allantoin  (EXP)
allopurinol  (EXP)
allyl alcohol  (EXP)
allyl methyl disulfide  (ISO)
Aloe emodin  (ISO)
alpha-Chaconine  (ISO)
alpha-D-galactose  (ISO)
alpha-linolenic acid  (EXP,ISO)
alpha-mangostin  (EXP)
alpha-methylhistamine  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (ISO)
Alternaramide  (ISO)
alternariol  (ISO)
aluminium atom  (ISO)
aluminium hydroxide  (ISO)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (ISO)
amarogentin  (ISO)
amentoflavone  (ISO)
amikacin  (ISO)
amiloride  (EXP,ISO)
aminoguanidine  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
Ammothamnine  (ISO)
amodiaquine  (ISO)
amphetamine  (EXP)
amphibole asbestos  (EXP,ISO)
ampicillin  (EXP)
anandamide  (EXP,ISO)
Anemoside B4  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene-1,8,9-triol  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
arachidonic acid  (EXP,ISO)
Archazolid B  (ISO)
Arctiin  (ISO)
arecoline  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
asarone  (ISO)
asbestos  (ISO)
asiatic acid  (ISO)
astaxanthin  (EXP,ISO)
astilbin  (ISO)
atenolol  (ISO)
atorvastatin calcium  (EXP)
ATP  (ISO)
atrazine  (EXP,ISO)
atropine  (EXP)
auranofin  (ISO)
auraptene  (ISO)
aureusidin  (ISO)
azathioprine  (ISO)
Azoxymethane  (EXP,ISO)
baicalein  (ISO)
baicalin  (EXP)
bellidifolin  (ISO)
benfotiamine  (ISO)
benzalkonium chloride  (ISO)
benzamide  (EXP)
benzatropine  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoic acid  (ISO)
Benzoyl peroxide  (ISO)
Benzoylpaeoniflorin  (ISO)
berberine  (ISO)
Bergenin  (EXP)
beryllium sulfate  (ISO)
Besigomsin  (ISO)
beta-amyrin  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-ionone  (ISO)
beta-naphthoflavone  (EXP)
beta-tocopherol  (EXP)
betulinic acid  (EXP)
bicalutamide  (ISO)
bifenthrin  (EXP,ISO)
biochanin A  (ISO)
biphenyl-2,2'-diol  (ISO)
biphenyl-2-ol  (ISO)
biphenyl-4,4'-diol  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol A dimethacrylate  (ISO)
Bisphenol A glycidylmethacrylate  (ISO)
bisphenol AF  (EXP,ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
Boldine  (EXP)
boric acid  (ISO)
bortezomib  (ISO)
Botulinum toxin type A  (EXP)
BQ 123  (EXP,ISO)
bromfenac  (ISO)
bromobenzene  (EXP)
brucine  (ISO)
bucladesine  (ISO)
budesonide  (EXP,ISO)
bufalin  (ISO)
bupivacaine  (ISO)
busulfan  (ISO)
butan-1-ol  (EXP,ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
Butralin  (EXP)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
camptothecin  (ISO)
candesartan  (ISO)
cannabidiol  (EXP,ISO)
cannabidiolic acid  (ISO)
capecitabine  (ISO)
capillarisin  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
captopril  (EXP,ISO)
carazolol  (ISO)
carbachol  (EXP)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (ISO)
carfilzomib  (ISO)
carnosic acid  (ISO)
carnosine  (ISO)
carrageenan  (EXP,ISO)
carvacrol  (EXP,ISO)
carvedilol  (EXP)
Cassiastearoptene  (EXP)
casticin  (EXP)
catalpol  (ISO)
CCCP  (ISO)
celastrol  (ISO)
celecoxib  (EXP,ISO)
cerium trichloride  (ISO)
ceruletide  (EXP)
cetylpyridinium  (ISO)
chaetoglobosin A  (ISO)
chenodeoxycholic acid  (ISO)
chloramphenicol  (ISO)
chlordecone  (ISO)
chlorobenzene  (ISO)
chlorogenic acid  (EXP,ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorothalonil  (ISO)
chlorphenamine  (ISO)
chlorpropham  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (EXP,ISO)
chondroitin sulfate  (ISO)
chromium(6+)  (ISO)
chrysin  (EXP,ISO)
chrysin 5,7-dimethyl ether  (EXP)
ciglitazone  (EXP,ISO)
cilostazol  (ISO)
cinaciguat  (EXP)
ciprofibrate  (ISO)
cirsilineol  (ISO)
Cirsimarin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
citronellol  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP)
cordycepin  (ISO)
corilagin  (ISO)
corn oil  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
cortisol  (EXP,ISO)
costunolide  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
cumene hydroperoxide  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP)
cypermethrin  (ISO)
cyprodinil  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
daidzein  (ISO)
dapagliflozin  (EXP)
dapoxetine  (EXP)
DAPT  (ISO)
daunorubicin  (EXP)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
Decursin  (ISO)
deguelin  (ISO)
dehydrocostus lactone  (ISO)
Dehydrodiisoeugenol  (ISO)
delphinidin  (ISO)
delta-tocopherol  (EXP)
demethoxycurcumin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
dextromethorphan  (ISO)
Diacetoxyscirpenol  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
dibenzofuran  (EXP)
dibenzoylmethane  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dieckol  (ISO)
dienogest  (ISO)
diethyl phthalate  (ISO)
Dihydrotanshinone I  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (EXP)
dimethoate  (EXP)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinic acid  (EXP)
dimethylarsinous acid  (ISO)
dioscin  (EXP)
diosgenin  (ISO)
diosmin  (EXP,ISO)
dioxygen  (EXP,ISO)
diphenhydramine  (ISO)
dipyridamole  (EXP,ISO)
diquat  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (EXP)
diuron  (ISO)
dizocilpine maleate  (ISO)
dobutamine  (ISO)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
DuP 697  (EXP,ISO)
edelfosine  (ISO)
EGTA acetoxymethyl ester  (ISO)
elemental selenium  (EXP,ISO)
embelin  (ISO)
emodin  (EXP,ISO)
enalapril  (EXP,ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
enniatin  (ISO)
entacapone  (ISO)
entinostat  (ISO)
equol  (ISO)
erastin  (EXP,ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
eriodictyol  (ISO)
eritoran  (ISO)
erlotinib hydrochloride  (ISO)
esmolol  (ISO)
ethanol  (EXP,ISO)
Ethyl pyruvate  (EXP,ISO)
ethylbenzene  (ISO)
ethylisopropylamiloride  (ISO)
etodolac  (EXP,ISO)
etoposide  (ISO)
etoricoxib  (EXP,ISO)
eugenol  (EXP,ISO)
eupatilin  (ISO)
everolimus  (EXP)
Evodiamine  (ISO)
famotidine  (EXP,ISO)
febuxostat  (EXP)
fenbendazole  (ISO)
fenhexamid  (ISO)
fenofibrate  (ISO)
ferric ammonium citrate  (ISO)
ferrosoferric oxide  (ISO)
ferrostatin-1  (EXP,ISO)
ferulic acid  (EXP,ISO)
Fexofenadine hydrochloride  (ISO)
finasteride  (EXP)
fisetin  (EXP)
Flavokawain A  (ISO)
flavone  (ISO)
fludioxonil  (ISO)
fludrocortisone  (ISO)
flufenamic acid  (ISO)
fluoranthene  (ISO)
fluoxetine  (EXP)
flupenthixol  (ISO)
flurbiprofen  (EXP,ISO)
Fluridone  (ISO)
flutamide  (ISO)
fluvoxamine  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
Forsythiaside  (ISO)
Fraxinellone  (ISO)
fructose  (EXP)
fucoidan  (ISO)
fucoxanthin  (ISO)
fulvestrant  (ISO)
Fulvic acid  (ISO)
furfural  (ISO)
furosemide  (EXP)
Fusarenone X  (ISO)
galactose  (ISO)
gallic acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP)
gamma-linolenic acid  (ISO)
gamma-tocopherol  (EXP,ISO)
Gastrodin  (ISO)
gefitinib  (ISO)
geldanamycin  (EXP)
gemcitabine  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (ISO)
genkwanin  (ISO)
gentamycin  (EXP)
geraniol  (EXP,ISO)
gingerol  (ISO)
ginsenoside C-K  (EXP,ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glyburide  (EXP)
glycidol  (EXP)
glycyrol  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP,ISO)
Goe 6976  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (EXP)
guaiacol  (ISO)
guggulsterone  (ISO)
GW 1929  (ISO)
GW 501516  (ISO)
haloperidol  (ISO)
halothane  (EXP)
harmaline  (ISO)
helenalin  (ISO)
helioxanthin  (ISO)
heparin  (EXP)
herbacetin  (EXP)
herbimycin  (EXP)
hesperetin  (EXP,ISO)
hesperidin  (EXP,ISO)
hexachlorobenzene  (ISO)
hexane  (ISO)
hinokiflavone  (ISO)
histamine  (EXP,ISO)
homocysteine  (ISO)
homoeriodictyol  (ISO)
Honokiol  (ISO)
hydrochlorothiazide  (EXP)
hydrogen chloride  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (ISO)
hydroxytyrosol  (ISO)
Ibudilast  (EXP)
ibuprofen  (EXP,ISO)
icariin  (ISO)
icariside II  (ISO)
icatibant  (EXP)
ICI 118551  (ISO)
icosanoid  (ISO)
ifosfamide  (EXP)
iloprost  (ISO)
imidacloprid  (EXP)
imidazoles  (ISO)
immunological adjuvant  (EXP)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
indoprofen  (ISO)
indoxyl sulfate  (EXP,ISO)
Inotodiol  (ISO)
irbesartan  (EXP)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP)
iron(III) citrate  (ISO)
iron(III) nitrilotriacetate  (EXP)
isatin  (EXP)
isoflurane  (EXP)
isoliquiritigenin  (EXP,ISO)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP,ISO)
isothiocyanate  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
JTE-013  (ISO)
juglone  (ISO)
kaempferol  (ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
kainic acid  (EXP,ISO)
kenpaullone  (EXP)
ketoconazole  (ISO)
ketoprofen  (ISO)
ketorolac  (EXP,ISO)
ketorolac tromethamine  (ISO)
KN-93  (ISO)
KT 5720  (ISO)
L-1,4-dithiothreitol  (ISO)
L-arginine  (EXP)
L-ascorbic acid  (EXP,ISO)
L-dehydroascorbic acid  (EXP)
L-gamma-glutamyl-L-cysteine  (ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
L-proline betaine  (ISO)
lactucin  (ISO)
lansoprazole  (EXP)
lapatinib  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
Leonurine  (EXP)
levamisole  (ISO)
levofloxacin  (ISO)
Licarin A  (EXP)
lidocaine  (EXP)
linoleic acid  (EXP,ISO)
linuron  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lipoxin A4  (EXP)
liraglutide  (EXP)
lithium chloride  (EXP,ISO)
lithocholic acid  (ISO)
loganin  (ISO)
lonafarnib  (ISO)
lornoxicam  (ISO)
losartan  (EXP,ISO)
lovastatin  (EXP,ISO)
Lucidone  (ISO)
lumiracoxib  (ISO)
lupeol  (EXP)
lutein  (ISO)
luteolin  (EXP,ISO)
Luteolin 7-methyl ether  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
lycorine  (ISO)
lysophosphatidylcholine  (EXP)
Malabaricone C  (ISO)
malaoxon  (ISO)
malathion  (ISO)
maleimides  (ISO)
mancozeb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
manoalide  (ISO)
maslinic acid  (ISO)
masoprocol  (ISO)
MC1568  (ISO)
mebendazole  (ISO)
mechlorethamine  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
melittin  (ISO)
meloxicam  (EXP,ISO)
melphalan  (ISO)
mercury dichloride  (EXP)
mesalamine  (EXP)
metaproterenol  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
Methanandamide  (ISO)
methanol  (ISO)
methiocarb  (ISO)
methotrexate  (EXP,ISO)
methoxamine  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methyltestosterone  (ISO)
metoprolol  (EXP,ISO)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
midostaurin  (EXP)
mifepristone  (EXP)
minocycline  (ISO)
miquelianin  (ISO)
misoprostol  (EXP)
mitomycin C  (ISO)
Mitotane  (ISO)
MitoTEMPO  (EXP,ISO)
Mitragynine  (ISO)
MK-2206  (ISO)
Mofezolac (TN)  (EXP)
monascin  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monotropein  (ISO)
montelukast  (ISO)
morin  (EXP)
morphine  (EXP,ISO)
Morroniside  (ISO)
morusin  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
myricitrin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP,ISO)
N(omega)-methyl-L-arginine  (ISO)
N,N-dimethylformamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-feruloyltyramine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-phosphocreatine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nabumetone  (EXP)
naphthalenes  (EXP,ISO)
naproxen  (EXP,ISO)
Narciclasine  (ISO)
naringin  (EXP,ISO)
NCX-4040  (ISO)
nebivolol  (ISO)
nectandrin B  (ISO)
Neferine  (EXP)
neoastilbin  (ISO)
neoechinulin A  (ISO)
neohesperidin dihydrochalcone  (ISO)
nerolidol  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nifedipine  (EXP,ISO)
Niflumic acid  (ISO)
nimesulide  (EXP,ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
nitrogen dioxide  (ISO)
nitroprusside  (ISO)
nobiletin  (EXP)
nomifensine  (ISO)
Nonylphenol  (EXP,ISO)
Nookatone  (EXP)
notoginsenoside R1  (ISO)
NS-398  (EXP,ISO)
o-anisidine  (ISO)
o-cresol  (EXP)
O-methylsalicylic acid  (ISO)
Obacunone  (ISO)
ochratoxin A  (ISO)
ofloxacin  (EXP)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleoyl ethanolamide  (ISO)
oleuropein  (EXP,ISO)
omeprazole  (EXP,ISO)
omethoate  (EXP)
onapristone  (EXP)
orciprenaline  (ISO)
organoselenium compound  (EXP,ISO)
oridonin  (EXP)
orlistat  (ISO)
oroxylin A  (ISO)
ouabain  (EXP)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
oxybenzone  (ISO)
oxytocin  (EXP,ISO)
ozone  (EXP,ISO)
p-tolualdehyde  (ISO)
Pachymic acid  (ISO)
paclitaxel  (ISO)
paeoniflorin  (ISO)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (ISO)
paroxetine  (ISO)
parthenolide  (EXP,ISO)
patchouli alcohol  (EXP)
PCB138  (ISO)
pelargonidin  (ISO)
penbutolol  (ISO)
pentane-2,3-dione  (ISO)
Pentoxifylline  (EXP)
peptidoglycan  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
Pf-06840003  (ISO)
PGI3  (ISO)
phenanthridone  (EXP)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenylarsine oxide  (EXP,ISO)
phenylbutazone  (ISO)
phenylephrine  (EXP)
phenylhydrazine  (ISO)
phenytoin  (EXP)
PhIP  (ISO)
phloretic acid  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (EXP,ISO)
phosphatidic acid  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
pifithrin-alpha hydrobromide  (EXP)
pinostrobin  (EXP)
pioglitazone  (EXP,ISO)
piperine  (ISO)
pipoxolan  (ISO)
pirimiphos-methyl  (ISO)
pirinixic acid  (ISO)
piroxicam  (EXP,ISO)
platinum  (ISO)
platinum(0)  (ISO)
platycodin D  (EXP,ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
poly(I:C)  (ISO)
poly(vinylpyrrolidone)  (EXP)
polymyxin B2  (ISO)
ponasterone A  (EXP)
potassium bromate  (ISO)
potassium chloride  (EXP)
potassium iodide  (ISO)
Pranoprofen  (ISO)
pravastatin  (EXP)
prednisolone  (ISO)
PRIM-O-GLUCOSYLCIMIFUGIN  (ISO)
pristane  (ISO)
proanthocyanidin  (EXP)
probenecid  (EXP)
procyclidine  (ISO)
prodigiosin  (EXP)
progesterone  (EXP,ISO)
propiconazole  (EXP)
propranolol  (ISO)
prostaglandin A1  (ISO)
prostaglandin D2  (ISO)
prostaglandin D3  (ISO)
prostaglandin E2  (EXP,ISO)
prostaglandin E3  (ISO)
prostaglandin F1alpha  (ISO)
prostaglandin F2alpha  (EXP,ISO)
prostaglandin G2  (ISO)
prostaglandin I2  (EXP)
protein kinase inhibitor  (ISO)
protoporphyrin  (ISO)
protriptyline  (ISO)
prunetin  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
puromycin  (ISO)
pyrazines  (ISO)
pyrene  (ISO)
pyridoxamine  (ISO)
pyrimethanil  (ISO)
pyrogallol  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quercetin 3-sulfate  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP,ISO)
ramipril  (EXP)
ranitidine  (EXP)
reactive oxygen species  (EXP,ISO)
Rebamipide  (EXP)
rebaudioside A  (ISO)
reserpine  (EXP)
resolvin D1  (ISO)
resolvin D2  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
rimonabant  (ISO)
rivastigmine  (ISO)
Ro 31-8220  (ISO)
rofecoxib  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
rubimaillin  (ISO)
Rutecarpine  (ISO)
rutin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
Salvianolic acid A  (ISO)
sarpogrelate  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SC-58125  (EXP,ISO)
SC-791  (ISO)
scalaradial  (ISO)
scoparone  (ISO)
scopolamine  (ISO)
selenium atom  (EXP,ISO)
senecionine  (ISO)
Senkirkine  (ISO)
serotonin  (EXP,ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
Sesamol  (ISO)
sevoflurane  (EXP)
Shikonin  (ISO)
silibinin  (ISO)
silicon atom  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP,ISO)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium aurothiomalate  (ISO)
sodium chloride  (EXP,ISO)
sodium chromate  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (EXP,ISO)
sodium hydrogensulfite  (EXP,ISO)
Sodium salicylate  (ISO)
sodium sulfite  (EXP)
Soman  (EXP)
Sophocarpine  (ISO)
Sophoricoside  (ISO)
sorbinil  (ISO)
soyasaponin I  (ISO)
sphinganine 1-phosphate  (ISO)
sphingosine 1-phosphate  (ISO)
staurosporine  (ISO)
stavudine  (ISO)
sterigmatocystin  (EXP)
steviol  (ISO)
stevioside  (ISO)
stigmasterol  (ISO)
streptozocin  (EXP,ISO)
styrene  (ISO)
succimer  (ISO)
succinic acid  (ISO)
sucrose  (EXP)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (EXP,ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (EXP,ISO)
superoxide  (ISO)
suramin  (ISO)
Swertiamarin  (EXP)
syringic acid  (EXP)
T-2 toxin  (ISO)
tacrine  (EXP,ISO)
tacrolimus hydrate  (ISO)
taiwanin C  (ISO)
tamarixetin  (ISO)
tamoxifen  (ISO)
tangeretin  (EXP)
tannic acid  (EXP)
Tanshinone I  (ISO)
taurocholic acid  (ISO)
taurodeoxycholic acid  (EXP)
tebuconazole  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (ISO)
TEMPO  (ISO)
tenofovir disoproxil fumarate  (EXP)
tephrosin  (ISO)
terameprocol  (ISO)
terephthalic acid  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP)
Testosterone propionate  (EXP)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
tetradecane  (EXP)
tetrahydrocurcumin  (ISO)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (ISO)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (ISO)
thalidomide  (EXP,ISO)
thapsigargin  (ISO)
theaflavin  (ISO)
Theaflavin 3,3'-digallate  (EXP)
Thiamet G  (ISO)
thiamethoxam  (ISO)
thiamine(1+) chloride  (EXP)
thioacetamide  (EXP,ISO)
thiocitrulline  (EXP)
thiophanate-methyl  (EXP)
thiourea  (ISO)
thiram  (ISO)
thromboxane A2  (ISO)
thromboxane B2  (ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
thyroxine  (EXP,ISO)
tienilic acid  (ISO)
titanium dioxide  (EXP,ISO)
tolcapone  (ISO)
tolterodine tartrate  (ISO)
toluene  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trans-piceid  (ISO)
trazodone  (EXP,ISO)
Tremulacin  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
Trihexyphenidyl  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (EXP,ISO)
Tylophorine  (ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
undecane  (EXP)
uranium atom  (EXP)
urethane  (EXP,ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vanadyl sulfate  (ISO)
vanillin  (ISO)
vemurafenib  (ISO)
venom  (ISO)
vincristine  (ISO)
vinorelbine  (ISO)
vinyl carbamate  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (ISO)
VX nerve agent  (EXP)
wedelolactone  (ISO)
withaferin A  (ISO)
wogonin  (ISO)
wortmannin  (ISO)
xanthohumol  (EXP,ISO)
yohimbine  (EXP)
zafirlukast  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zidovudine  (ISO)
zileuton  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IMP)
bone mineralization  (IMP)
brown fat cell differentiation  (ISO)
cellular oxidant detoxification  (IEA)
cellular response to ATP  (IEP)
cellular response to fluid shear stress  (ISO)
cellular response to heat  (IEP)
cellular response to homocysteine  (IEP)
cellular response to hypoxia  (ISO)
cellular response to lead ion  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to mechanical stimulus  (IEP)
cellular response to non-ionic osmotic stress  (ISO)
cyclooxygenase pathway  (IBA,ISO,ISS)
decidualization  (IMP,ISO)
embryo implantation  (IMP,ISO)
fatty acid biosynthetic process  (IEA)
fatty acid metabolic process  (IEA)
hair cycle  (IEP)
learning  (IMP)
lipid metabolic process  (IEA)
maintenance of blood-brain barrier  (IMP)
memory  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of calcium ion transport  (IMP)
negative regulation of cell cycle  (IGI)
negative regulation of cell population proliferation  (IDA)
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  (ISO)
negative regulation of smooth muscle contraction  (IMP)
negative regulation of synaptic transmission, dopaminergic  (IMP)
positive regulation of apoptotic process  (IMP)
positive regulation of brown fat cell differentiation  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of fever generation  (IDA,ISO)
positive regulation of fibroblast growth factor production  (IMP)
positive regulation of nitric oxide biosynthetic process  (IMP)
positive regulation of platelet-derived growth factor production  (IMP)
positive regulation of prostaglandin biosynthetic process  (ISO)
positive regulation of protein import into nucleus  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of smooth muscle contraction  (IMP)
positive regulation of synaptic plasticity  (IMP)
positive regulation of synaptic transmission, glutamatergic  (IMP)
positive regulation of transforming growth factor beta production  (IMP)
positive regulation of vascular endothelial growth factor production  (IMP)
positive regulation of vasoconstriction  (IMP)
prostaglandin biosynthetic process  (IEA,IMP,ISO)
prostaglandin metabolic process  (IEA,ISO)
prostaglandin secretion  (ISO)
prostanoid biosynthetic process  (ISO)
regulation of blood pressure  (ISO,ISS)
regulation of cell population proliferation  (ISO)
regulation of neuroinflammatory response  (ISO,ISS)
response to angiotensin  (IEP)
response to cytokine  (IMP)
response to estradiol  (IEP)
response to fatty acid  (IEP)
response to fructose  (IEP)
response to glucocorticoid  (IEP)
response to lipopolysaccharide  (IMP)
response to manganese ion  (IEP)
response to nematode  (ISO)
response to oxidative stress  (IEA)
response to selenium ion  (ISO)
response to tumor necrosis factor  (IEP)
response to vitamin D  (IEP)
response to xenobiotic stimulus  (IEP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (IEA,ISO)
celecoxib pharmacodynamics pathway  (ISO)
celecoxib pharmacokinetics pathway   (ISO)
cyclooxygenase mediated pathway of arachidonic acid metabolism  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
etoposide pharmacodynamics pathway  (ISO)
etoposide pharmacokinetics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacokinetics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
Leishmaniasis pathway  (IEA)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway   (ISO)
paracetamol drug pathway  (ISO)
piroxicam pharmacodynamics pathway  (ISO)
pro-inflammatory cytokine mediated pathway   (IDA)
prostanoid biosynthetic pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
small cell lung carcinoma pathway  (IEA)
sodium salicylate pharmacodynamics pathway  (ISO)
sphingosine 1-phosphate signaling pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway   (ISO)
vascular endothelial growth factor signaling pathway  (IEA)

References

References - curated
# Reference Title Reference Citation
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2. Celecoxib as an in vivo probe of cyclooxygenase-2 mechanisms underlying retrograde amnesia in an animal model of ECT. Andrade C, etal., J Neural Transm. 2008 Jul;115(7):1063-70. Epub 2008 Jun 4.
3. Selective inhibition of cyclooxygenase-2 (COX-2) by 1alpha,25-dihydroxy-16-ene-23-yne-vitamin D3, a less calcemic vitamin D analog. Aparna R, etal., J Cell Biochem. 2008 Aug 1;104(5):1832-42.
4. The prognostic significance of COX-2 and survivin expression in ovarian cancer. Athanassiadou P, etal., Pathol Res Pract. 2008;204(4):241-9. Epub 2008 Jan 2.
5. The neuroprotective effects of cyclooxygenase-2 inhibition in a mouse model of aneurysmal subarachnoid hemorrhage. Ayer R, etal., Acta Neurochir Suppl. 2011;111:145-9.
6. Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE). Ayoub SS, etal., Inflamm Res. 2011 Oct;60(10):919-28. Epub 2011 Jun 12.
7. Loss of 15-hydroxyprostaglandin dehydrogenase indicates a tumor suppressor role in pituitary adenomas. Bai JW, etal., Oncol Rep. 2012 Aug;28(2):714-20. doi: 10.3892/or.2012.1806. Epub 2012 May 9.
8. Overexpression of ELAV-like Protein HuR is Associated with Increased COX-2 Expression in Atrophy, High-grade Prostatic Intraepithelial Neoplasia, and Incidental Prostate Cancer in Cystoprostatectomies. Barbisan F, etal., Eur Urol. 2008 Apr 30.
9. Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension. Baserga M, etal., Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1943-55. Epub 2007 Feb 1.
10. Serum Concentrations of Cyclooxygenase-2 in Patients with Systemic Sclerosis: Association with Lower Frequency of Pulmonary Fibrosis. Bassyouni IH, etal., J Clin Immunol. 2011 Oct 7.
11. Perioperative use of beta-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis. Benish M, etal., Ann Surg Oncol. 2008 Jul;15(7):2042-52. Epub 2008 Apr 9.
12. Inhibition of cyclooxygenase-2 aggravates secretory phospholipase A2-mediated progression of acute liver injury. Bhave VS, etal., Toxicol Appl Pharmacol. 2008 Apr 15;228(2):239-46. Epub 2008 Jan 4.
13. COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia. Birkenmeier K, etal., Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2148-54. Epub 2007 Jul 27.
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17. Genes that mediate breast cancer metastasis to the brain. Bos PD, etal., Nature. 2009 Jun 18;459(7249):1005-9. Epub 2009 May 6.
18. Chronic lithium downregulates cyclooxygenase-2 activity and prostaglandin E(2) concentration in rat brain. Bosetti F, etal., Mol Psychiatry. 2002;7(8):845-50.
19. Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling. Brambilla R, etal., J Neurochem 2002 Dec;83(6):1285-96.
20. PGE2 induces apoptosis of hepatic stellate cells and attenuates liver fibrosis in mice by downregulating miR-23a-5p and miR-28a-5p. Brea R, etal., Biochim Biophys Acta Mol Basis Dis. 2018 Feb;1864(2):325-337. doi: 10.1016/j.bbadis.2017.11.001. Epub 2017 Nov 3.
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22. Key enzymes for renal prostaglandin synthesis: site-specific expression in rodent kidney (rat, mouse). Campean V, etal., Am J Physiol Renal Physiol 2003 Jul;285(1):F19-32. Epub 2003 Mar 25.
23. Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat. Candelario-Jalil E, etal., J Pharmacol Exp Ther. 2007 Nov;323(2):488-98. Epub 2007 Aug 17.
24. Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. Carey MA, etal., J Immunol. 2005 Nov 15;175(10):6878-84.
25. Anti-inflammatory effects of low molecular weight heparin derivative in a rat model of carrageenan-induced pleurisy. Ceccarelli M, etal., J Cell Mol Med. 2009 Aug;13(8B):2704-12.
26. Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children. Chan IH, etal., Allergy. 2007 Jul;62(7):802-9.
27. Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease. Chang JW, etal., Neurobiol Aging. 1996 Sep-Oct;17(5):801-8.
28. Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-kappaB/COX-2/PGE2. Chen J, etal., Hum Reprod. 2012 Sep;27(9):2585-97. doi: 10.1093/humrep/des254. Epub 2012 Jul 9.
29. Celecoxib attenuates liver steatosis and inflammation in non-alcoholic steatohepatitis induced by high-fat diet in rats. Chen J, etal., Mol Med Report. 2011 Jun 2. doi: 10.3892/mmr.2011.501.
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31. Expression of c-erbB-2 and cyclooxygenase-2 in intrahepatic cholangiocarcinoma. Choi HJ, etal., Hepatogastroenterology. 2009 May-Jun;56(91-92):606-9.
32. FSH-regulated gene expression profiles in ovarian tumours and normal ovaries. Chu S, etal., Mol Hum Reprod. 2002 May;8(5):426-33.
33. Intraprostatic botulinum toxin a injection inhibits cyclooxygenase-2 expression and suppresses prostatic pain on capsaicin induced prostatitis model in rat. Chuang YC, etal., J Urol. 2008 Aug;180(2):742-8. Epub 2008 Jun 13.
34. Anti-inflammatory effect of low intensity ultrasound (LIUS) on complete Freund's adjuvant-induced arthritis synovium. Chung JI, etal., Osteoarthritis Cartilage. 2012 Jan 24.
35. A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. Cipollone F, etal., JAMA. 2004 May 12;291(18):2221-8.
36. Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression. Colby JK, etal., Neoplasia. 2008 Aug;10(8):782-96.
37. COX-2, but not COX-1, activity is necessary for the induction of perforant path long-term potentiation and spatial learning in vivo. Cowley TR, etal., Eur J Neurosci. 2008 Jun;27(11):2999-3008. Epub 2008 Jun 6.
38. Genetic Variations in Inflammatory Response Genes and Their Association with the Risk of Prostate Cancer. Cui X, etal., Biomed Res Int. 2015;2015:674039. doi: 10.1155/2015/674039. Epub 2015 Dec 14.
39. Prostaglandin-endoperoxide synthase genes COX1 and COX2 - novel modifiers of disease severity in cystic fibrosis patients. Czerska K, etal., J Appl Genet. 2010;51(3):323-30.
40. Different parkinsonism models produce a time-dependent induction of COX-2 in the substantia nigra of rats. de Meira Santos Lima M, etal., Brain Res. 2006 Jul 26;1101(1):117-25. Epub 2006 Jun 15.
41. Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma. Deininger MH and Schluesener HJ, J Neuroimmunol. 1999 Mar 1;95(1-2):202-8.
42. Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression. Deininger MH, etal., Brain Res. 2000 Dec 1;885(1):111-6.
43. Cyclooxygenase-1 and -2 in brains of patients who died with sporadic Creutzfeldt-Jakob disease. Deininger MH, etal., J Mol Neurosci. 2003 Feb;20(1):25-30.
44. Hypoxia-induced hyperreactivity of pulmonary arteries: role of cyclooxygenase-2, isoprostanes, and thromboxane receptors. Delannoy E, etal., Cardiovasc Res. 2010 Feb 1;85(3):582-92. Epub 2009 Aug 26.
45. Protective effect of cyclooxygenase-2 (COX-2) inhibitors but not non-selective cyclooxygenase (COX)-inhibitors on ethanol withdrawal-induced behavioural changes. Dhir A, etal., Addict Biol. 2005 Dec;10(4):329-35.
46. Neuroprotective Effect of Cyclooxygenase Inhibitors in ICV-STZ Induced Sporadic Alzheimer's Disease in Rats. Dhull DK, etal., J Mol Neurosci. 2012 Jan;46(1):223-35. Epub 2011 Jun 24.
47. Rat ovulation, implantation and decidualization are severely compromised by COX-2 inhibitors. Diao HL, etal., Front Biosci. 2007 May 1;12:3333-42.
48. Celecoxib has Potent Antitumour Effects as a Single Agent and in Combination with BCG Immunotherapy in a Model of Urothelial Cell Carcinoma. Dovedi SJ, etal., Eur Urol. 2008 Sep;54(3):621-30. Epub 2008 Jan 15.
49. Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells. DuBois RN, etal., Am J Physiol. 1994 May;266(5 Pt 1):G822-7.
50. Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury. Durrenberger PF, etal., J Peripher Nerv Syst. 2004 Mar;9(1):15-25.
51. Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension. Eizayaga FX, etal., World J Gastroenterol. 2007 Oct 14;13(38):5065-5070.
52. CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer. Ellinger J, etal., Urology. 2008 Jan;71(1):161-7.
53. Glutamine contributes to ameliorate inflammation after renal ischemia/reperfusion injury in rats. Esposito E, etal., Naunyn Schmiedebergs Arch Pharmacol. 2011 May;383(5):493-508. Epub 2011 Mar 11.
54. Dopaminergic but Not Glutamatergic Neurotransmission Is Increased in the Striatum after Selective Cyclooxygenase-2 Inhibition in Normal and Hemiparkinsonian Rats. Fathi Moghaddam H, etal., Basic Clin Pharmacol Toxicol. 2008 Aug 28.
55. Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia. Feng AW, etal., Fitoterapia. 2011 May 27.
56. Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression. Feng L, etal., Arch Biochem Biophys 1993 Dec;307(2):361-8.
57. Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat. Fillmann H, etal., Toxicology. 2007 Jul 17;236(3):217-26. Epub 2007 Apr 27.
58. Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility. Fredenburgh LE, etal., Trends Cardiovasc Med. 2009 Feb;19(2):31-7.
59. Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats. Freshwater JD, etal., Diabetes 2002 Jul;51(7):2249-55.
60. Expression of cyclooxygenase-2 in Wilms tumor: immunohistochemical study using tissue microarray methodology. Fridman E, etal., J Urol. 2006 Oct;176(4 Pt 2):1747-50.
61. Local and systemic expression of inducible nitric oxide synthase in comparison with that of cyclooxygenase-2 in rat carrageenin-induced pleurisy. Fujisawa H, etal., Nitric Oxide. 2005 Mar;12(2):80-8.
62. Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor. Funahashi H, etal., Cancer Res. 2007 Aug 1;67(15):7068-71. Epub 2007 Jul 24.
63. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
64. Selective inhibition of cyclooxygenase-2 suppresses metastatic disease without affecting primary tumor growth in a murine model of Ewing sarcoma. Gendy AS, etal., J Pediatr Surg. 2011 Jan;46(1):108-14.
65. COX-2 polymorphisms -765G→C and -1195A→G and hepatocellular carcinoma risk. Gharib AF, etal., Gene. 2014 Jun 15;543(2):234-6. doi: 10.1016/j.gene.2014.04.014. Epub 2014 Apr 8.
66. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
67. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Graham GG, etal., Inflammopharmacology. 2013 Jun;21(3):201-32. doi: 10.1007/s10787-013-0172-x. Epub 2013 May 30.
68. Further assessment of the clinically effective dose range of etoricoxib: a randomized, double-blinded, placebo-controlled trial in rheumatoid arthritis. Greenwald M, etal., Curr Med Res Opin. 2011 Oct;27(10):2033-42. Epub 2011 Sep 12.
69. Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. Grimminger PP, etal., J Oncol. 2009;2009:139590. Epub 2009 Nov 22.
70. Experimental sepsis-associated encephalopathy is accompanied by altered cerebral blood perfusion and water diffusion and related to changes in cyclooxygenase-2 expression and glial cell morphology but not to blood-brain barrier breakdown. Griton M, etal., Brain Behav Immun. 2020 Jan;83:200-213. doi: 10.1016/j.bbi.2019.10.012. Epub 2019 Oct 14.
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218. Post-training cyclooxygenase-2 (COX-2) inhibition impairs memory consolidation. Teather LA, etal., Learn Mem 2002 Jan-Feb;9(1):41-7.
219. Cyclooxygenase-2 contributes to VX-induced cell death in cultured cortical neurons. Tenn CC, etal., Toxicol Lett. 2012 Jan 28;210(1):71-77.
220. Expression and activity of cyclooxygenase isoforms in skeletal muscles and myocardium of humans and rodents. Testa M, etal., J Appl Physiol. 2007 Oct;103(4):1412-8. Epub 2007 Aug 2.
221. Chemopreventive action of diclofenac in dimethybenzanthracene induced lung cancer in female Wistar rat. Thakur P and Sanyal SN, J Environ Pathol Toxicol Oncol. 2010;29(3):255-65.
222. Epithelial COX-2 expression is not regulated by nitric oxide in rodent renal cortex. Theilig F, etal., Hypertension 2002 Apr;39(4):848-53.
223. [A cyclooxygenase-2 selective inhibitor worsens respiratory function and enhances mast cell activity in ovalbumin-sensitized mice]. Torres R, etal., Arch Bronconeumol. 2009 Apr;45(4):162-7. Epub 2009 Apr 1.
224. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Tsujii M, etal., Cell. 1998 May 29;93(5):705-16.
225. Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenase-2 expression in neocortex. Tu B and Bazan NG, Exp Neurol 2003 Feb;179(2):167-75.
226. CDX2, COX2 and MUC2 expressions in Barrett's esophagus: can they be useful in determination of the dysplasia? Turkmen IC, etal., Turk Patoloji Derg. 2012;28(3):251-8. doi: 10.5146/tjpath.2012.01132.
227. Upregulation of cyclooxygenase-2 by motorcycle exhaust particulate-induced reactive oxygen species enhances rat vascular smooth muscle cell proliferation. Tzeng HP, etal., Chem Res Toxicol. 2007 Aug;20(8):1170-6. Epub 2007 Jul 24.
228. Association study of candidate genes for the prevalence and progression of knee osteoarthritis. Valdes AM, etal., Arthritis Rheum. 2004 Aug;50(8):2497-507.
229. Prevention by celecoxib of secondary hyperalgesia induced by formalin in rats. Veiga AP, etal., Life Sci. 2004 Oct 22;75(23):2807-17.
230. Association between cyclooxygenase-2 expression in atypical hyperplasia and risk of breast cancer. Visscher DW, etal., J Natl Cancer Inst. 2008 Mar 19;100(6):421-7. Epub 2008 Mar 11.
231. Cyclooxygenase 2 pathway mediates IL-1beta regulation of IL-1alpha, -1beta, and IL-6 mRNA levels in Leydig cell progenitors. Walch L and Morris PL, Endocrinology 2002 Sep;143(9):3276-83.
232. Selective cyclooxygenase-2 inhibition upregulates renal cortical alpha V integrin expression. Waldner C, etal., Nephron Exp Nephrol 2003;93(2):e72.
233. Lead induces COX-2 expression in glial cells in a NFAT-dependent, AP-1/NF¿B-independent manner. Wei J, etal., Toxicology. 2014 Nov 5;325:67-73. doi: 10.1016/j.tox.2014.08.012. Epub 2014 Sep 2.
234. COX2 inhibition reduces aortic valve calcification in vivo. Wirrig EE, etal., Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):938-47. doi: 10.1161/ATVBAHA.114.305159. Epub 2015 Feb 26.
235. Chemopreventive effects of celecoxib are limited to hormonally responsive mammary carcinomas in the neu-induced retroviral rat model. Woditschka S, etal., Breast Cancer Res. 2008;10(1):R18. Epub 2008 Feb 15.
236. Pivotal role of protein kinase Cdelta in angiotensin II-induced endothelial cyclooxygenase-2 expression: a link to vascular inflammation. Wong SL, etal., Arterioscler Thromb Vasc Biol. 2011 May;31(5):1169-76. doi: 10.1161/ATVBAHA.110.216044. Epub 2011 Feb 10.
237. Suppressing cyclooxygenase-2 prevents nonalcoholic and inhibits apoptosis of hepatocytes that are involved in the Akt/p53 signal pathway. Wu J, etal., Biochem Biophys Res Commun. 2016 Jan 22;469(4):1034-40. doi: 10.1016/j.bbrc.2015.12.096. Epub 2015 Dec 23.
238. Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain. Wu T, etal., J Neuroinflammation. 2011 Mar 8;8:22.
239. Co-overexpression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 adversely affects the postoperative survival in non-small cell lung cancer. Wu YC, etal., J Thorac Oncol. 2010 Aug;5(8):1167-74.
240. [The effect of nitric oxide inhalation on the expression of COX-2 and toll-like receptor 4 in rat acute lung injury induced by lipopolysaccharide]. Wu YW, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2009 Feb;32(2):111-4.
241. A haplotype of cyclooxygenase-2 gene is associated with idiopathic pulmonary fibrosis. Xaubet A, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2010 Jul;27(2):121-30.
242. [Effect of letrozole on endometrosis and apoptosis of ectopic endometrial cells in rats]. Xia X, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Jan;38(1):54-9. doi: 10.3969/j.issn.1672-7347.2013.01.010.
243. Down-regulated CFTR During Aging Contributes to Benign Prostatic Hyperplasia. Xie C, etal., J Cell Physiol. 2015 Aug;230(8):1906-15. doi: 10.1002/jcp.24921.
244. [Association between single nucleotide polymorphisms in the promoter of cyclooxygenase COX-2 gene and hereditary susceptibility to pancreatic cancer]. Xu DK, etal., Zhonghua Yi Xue Za Zhi. 2008 Jul 22;88(28):1961-5.
245. Immediate-early MEK-1-dependent stabilization of rat smooth muscle cell cyclooxygenase-2 mRNA by Galpha(q)-coupled receptor signaling. Xu K, etal., J Biol Chem 2000 Jul 28;275(30):23012-9.
246. Expression pattern of cyclooxygenase-2 in normal rat epidermis and pilosebaceous unit during hair cycle. Xu Y, etal., Acta Histochem Cytochem. 2008 Dec 27;41(6):157-63. Epub 2008 Oct 28.
247. Involvement of hypothalamic cyclooxygenase-2, interleukin-1ß and melanocortin in the development of docetaxel-induced anorexia in rats. Yamamoto K, etal., Toxicology. 2012 Dec 16;302(2-3):190-6. doi: 10.1016/j.tox.2012.07.015. Epub 2012 Aug 4.
248. Profiling of genetic variations in inflammation pathway genes in relation to bladder cancer predisposition. Yang H, etal., Clin Cancer Res. 2008 Apr 1;14(7):2236-44.
249. A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2. Yeoh AS, etal., Mol Cancer Ther. 2007 Aug;6(8):2319-27.
250. The protective role of Kangen-karyu against fructose-induced metabolic syndrome in a rat model. Yokozawa T, etal., J Pharm Pharmacol. 2007 Sep;59(9):1271-8.
251. Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system. Yoshikawa K, etal., Brain Res. 2011 Jan 7;1367:22-32. doi: 10.1016/j.brainres.2010.10.019. Epub 2010 Oct 13.
252. Expression of cyclooxygenase-1 and -2 in human breast cancer. Yoshimura N, etal., Surg Today. 2003;33(11):805-11.
253. Prognostic value of cyclooxygenase-2 expression in squamous cell carcinoma of the bladder. Youssef RF, etal., J Urol. 2011 Mar;185(3):1112-7. Epub 2011 Jan 21.
254. The anti-inflammatory effect of celecoxib does not prevent liver fibrosis in bile duct-ligated rats. Yu J, etal., Liver Int. 2008 Apr 23.
255. Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1/cip-1 and p27kip-1. Zahner G, etal., J Biol Chem 2002 Mar 22;277(12):9763-71.
256. Correlation of microRNA-16, microRNA-21 and microRNA-101 expression with cyclooxygenase-2 expression and angiogenic factors in cirrhotic and noncirrhotic human hepatocellular carcinoma. Zeng W, etal., PLoS One. 2014 Apr 23;9(4):e95826. doi: 10.1371/journal.pone.0095826. eCollection 2014.
257. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
258. Cyclooxygenase 2 promotes parathyroid hyperplasia in ESRD. Zhang Q, etal., J Am Soc Nephrol. 2011 Apr;22(4):664-72. Epub 2011 Feb 18.
259. [The effect of nimesulide on learning and memory function after serve traumatic brain injury in rats]. Zhang T and Zhang YX, Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Jul;42(4):498-502.
260. Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. Zhang X, etal., Gastroenterology. 2005 Aug;129(2):565-76.
261. The effect of adrenomedullin on the L-type calcium current in myocytes from septic shock rats: Signaling pathway. Zhang XH, etal., Am J Physiol Heart Circ Physiol. 2007 Aug 31;.
262. Interaction of cyclooxygenase-2 variants and smoking in pancreatic cancer: a possible role of nucleophosmin. Zhao D, etal., Gastroenterology. 2009 May;136(5):1659-68.
263. Cyclooxygenase-2 expression during immortalization and breast cancer progression. Zhao X, etal., Cancer Res. 2008 Jan 15;68(2):467-75. doi: 10.1158/0008-5472.CAN-07-0782.
264. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Zheng L, etal., Biomed Pharmacother. 2018 Jan;97:481-488. doi: 10.1016/j.biopha.2017.10.153. Epub 2017 Nov 6.
Additional References at PubMed
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Genomics

Comparative Map Data
Ptgs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,714,063 - 64,722,320 (+)NCBIGRCr8
mRatBN7.21362,163,936 - 62,172,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1362,163,932 - 62,172,188 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1364,798,537 - 64,804,239 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01366,083,346 - 66,089,057 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,344,882 - 63,350,588 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,351,230 - 67,356,920 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,351,087 - 67,359,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,315,959 - 72,324,483 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,427,288 - 64,432,978 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11364,441,245 - 64,449,480 (+)NCBI
Celera1362,129,439 - 62,135,131 (+)NCBICelera
Cytogenetic Map13q21NCBI
PTGS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,671,791 - 186,680,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,671,791 - 186,680,922 (-)EnsemblGRCh38hg38GRCh38
GRCh371186,640,923 - 186,649,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361184,907,592 - 184,916,179 (-)NCBINCBI36Build 36hg18NCBI36
Build 341183,372,625 - 183,381,213NCBI
Celera1159,751,694 - 159,760,309 (-)NCBICelera
Cytogenetic Map1q31.1NCBI
HuRef1157,875,712 - 157,884,327 (-)NCBIHuRef
CHM1_11188,062,673 - 188,071,288 (-)NCBICHM1_1
T2T-CHM13v2.01186,026,616 - 186,035,248 (-)NCBIT2T-CHM13v2.0
Ptgs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,975,851 - 149,983,978 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,975,782 - 149,983,978 (+)EnsemblGRCm39 Ensembl
GRCm381150,100,031 - 150,108,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,100,031 - 150,108,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv371151,947,254 - 151,955,147 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361151,862,342 - 151,870,235 (+)NCBIMGSCv36mm8
Celera1152,546,728 - 152,554,611 (+)NCBICelera
Cytogenetic Map1G1NCBI
cM Map163.84NCBI
Ptgs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540625,079,945 - 25,086,171 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540625,077,988 - 25,086,259 (-)NCBIChiLan1.0ChiLan1.0
PTGS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2163,030,462 - 63,041,820 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1162,713,923 - 62,723,110 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,205,534 - 162,214,130 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,355,845 - 166,364,517 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,355,845 - 166,364,519 (-)Ensemblpanpan1.1panPan2
PTGS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1719,668,079 - 19,674,903 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl719,668,082 - 19,674,903 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha719,190,741 - 19,197,565 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0719,405,501 - 19,412,325 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl719,405,504 - 19,412,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1719,311,510 - 19,318,356 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0719,420,827 - 19,427,651 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0719,552,954 - 19,559,778 (-)NCBIUU_Cfam_GSD_1.0
Ptgs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934485,975,505 - 85,982,237 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364813,821,564 - 3,828,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9127,850,015 - 127,858,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19127,850,164 - 127,858,866 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29140,251,667 - 140,260,362 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12542,733,535 - 42,742,463 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2542,734,771 - 42,742,429 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605543,903,786 - 43,913,892 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248146,897,857 - 6,903,728 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248146,897,818 - 6,904,890 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptgs2
43 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:141
Count of miRNA genes:92
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000003567
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303028Bp329Blood pressure QTL 329arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135849787273485113Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat

Markers in Region
Ptgs2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21362,167,881 - 62,168,027 (+)MAPPERmRatBN7.2
Rnor_6.01367,355,032 - 67,355,177NCBIRnor6.0
Rnor_5.01372,320,172 - 72,320,317UniSTSRnor5.0
RGSC_v3.41364,431,090 - 64,431,235UniSTSRGSC3.4
Celera1362,133,243 - 62,133,388UniSTS
Cytogenetic Map13q21UniSTS
PMC27868P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21362,168,413 - 62,169,075 (+)MAPPERmRatBN7.2
Rnor_6.01367,355,564 - 67,356,225NCBIRnor6.0
Rnor_5.01372,320,704 - 72,321,365UniSTSRnor5.0
RGSC_v3.41364,431,622 - 64,432,283UniSTSRGSC3.4
Celera1362,133,775 - 62,134,436UniSTS
Cytogenetic Map13q21UniSTS
Ptgs2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21362,168,415 - 62,169,644 (+)MAPPERmRatBN7.2
Rnor_6.01367,355,566 - 67,356,794NCBIRnor6.0
Rnor_5.01372,320,706 - 72,321,934UniSTSRnor5.0
RGSC_v3.41364,431,624 - 64,432,852UniSTSRGSC3.4
Celera1362,133,777 - 62,135,005UniSTS
Cytogenetic Map13q21UniSTS


Genetic Models
This gene Ptgs2 is modified in the following models/strains:
SS-Ptgs2em1Mcwi     SS-Ptgs2em2Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 48 113 90 89 58 25 58 6 215 95 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000003567   ⟹   ENSRNOP00000003567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1362,163,932 - 62,172,188 (+)Ensembl
Rnor_6.0 Ensembl1367,351,087 - 67,359,335 (+)Ensembl
RefSeq Acc Id: NM_017232   ⟹   NP_058928
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81364,714,063 - 64,722,320 (+)NCBI
mRatBN7.21362,163,936 - 62,172,193 (+)NCBI
Rnor_6.01367,351,230 - 67,356,920 (+)NCBI
Rnor_5.01372,315,959 - 72,324,483 (+)NCBI
RGSC_v3.41364,427,288 - 64,432,978 (+)RGD
Celera1362,129,439 - 62,135,131 (+)RGD
Sequence:
RefSeq Acc Id: NP_058928   ⟸   NM_017232
- Peptide Label: precursor
- UniProtKB: Q64379 (UniProtKB/Swiss-Prot),   Q925V4 (UniProtKB/Swiss-Prot),   P35355 (UniProtKB/Swiss-Prot),   A6ICR0 (UniProtKB/TrEMBL),   Q63124 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003567   ⟸   ENSRNOT00000003567
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35355-F1-model_v2 AlphaFold P35355 1-604 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698878
Promoter ID:EPDNEW_R9403
Type:single initiation site
Name:Ptgs2_1
Description:prostaglandin-endoperoxide synthase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01367,351,086 - 67,351,146EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620349 AgrOrtholog
BioCyc Gene G2FUF-17948 BioCyc
BioCyc Pathway PWY66-374 [C20 prostanoid biosynthesis] BioCyc
BioCyc Pathway Image PWY66-374 BioCyc
Ensembl Genes ENSRNOG00000002525 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003567 ENTREZGENE
  ENSRNOT00000003567.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.640.10 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro EGF-like_dom UniProtKB/Swiss-Prot
  Haem_peroxidase_animal UniProtKB/Swiss-Prot
  Haem_peroxidase_sf UniProtKB/Swiss-Prot
  Haem_peroxidase_sf_animal UniProtKB/Swiss-Prot
  Oxylipin_biosynth_metab UniProtKB/Swiss-Prot
KEGG Report rno:29527 UniProtKB/Swiss-Prot
NCBI Gene 29527 ENTREZGENE
PANTHER PROSTAGLANDIN G/H SYNTHASE UniProtKB/Swiss-Prot
  PTHR11903:SF8 UniProtKB/Swiss-Prot
Pfam An_peroxidase UniProtKB/Swiss-Prot
  EGF UniProtKB/Swiss-Prot
PharmGKB PTGS2 RGD
PhenoGen Ptgs2 PhenoGen
PRINTS ANPEROXIDASE UniProtKB/Swiss-Prot
PROSITE EGF_3 UniProtKB/Swiss-Prot
  PEROXIDASE_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002525 RatGTEx
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF48113 UniProtKB/Swiss-Prot
UniProt A0A8A1UB91_RAT UniProtKB/TrEMBL
  A6ICR0 ENTREZGENE, UniProtKB/TrEMBL
  A6ICR1_RAT UniProtKB/TrEMBL
  P35355 ENTREZGENE, UniProtKB/Swiss-Prot
  Q63124 ENTREZGENE, UniProtKB/TrEMBL
  Q64379 ENTREZGENE
  Q925V4 ENTREZGENE
UniProt Secondary Q64379 UniProtKB/Swiss-Prot
  Q925V4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Ptgs2  prostaglandin-endoperoxide synthase 2      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ptgs2  prostaglandin-endoperoxide synthase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
null catalyzes the generation of prostaglandins from arachidonic acids  
null catalyzes the generation of prostaglandins from arachidonic acids 628427
gene_disease highly expressed in neurodegenerative disorders 625680
gene_drugs ketorolac, a water-soluble and nonselective inhibitor blocks the enzyme activity, but it can increase gene expression in cells of the blood-brain barrier 625680
gene_expression expressed in kidney 70545
gene_expression expressed in specialized tissues like ovarian granulosa cells, macrophages, endothelium, and seimnal vesicles; developmentally regulated expression pattern 625680
gene_function catalyzes conversion of arachidonic acid to prostaglandin H2 625680
gene_function acts both as a deoxygenase and peroxidase 625680
gene_process may function in the metabolism of arachidonic acid into prostanoids 70545
gene_process has a role in renal salt and water excretion 70545
gene_process major medaitor of inflammatory responses 625680
gene_process major medaitor of inflammatory responses 628427
gene_process may be a cytokine regulator in Leydig progenitor cells 625680
gene_process key enzyme in prostaglandin biosynthesis 625680
gene_regulation expression in the juxtaglomerular apparatus during low-salt diet is greatly reduced by a direct feedback inhibition through ANG II 625680
gene_regulation mRNA and protein expressions increases in alpha-beta-methyleneATP-induced gliosis and is dependent on ERK1/2 but independent of calcium signaling 625680
gene_regulation induced by interleukin 1 beta in Leydig cells 625680