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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:15342
Term: acenaphthoquinone
Definition: An orthoquinone that is the 1,2-dioxo derivative of acenaphthene.
Chemical ID: MESH:C023722
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionISORGD:7310066480464CTDacenaphthenequinone results in increased expression of PTGS2 proteinPMID:17082565
Ptgs2multiple interactionsISORGD:7310066480464CTD[acenaphthenequinone results in increased chemical synthesis of Reactive Oxygen Species] which affects the expression of PTGS2 protein; Acetylcysteine inhibits the reaction [acenaphthenequinone results in increased expression of PTGS2 protein]; BAY 11-7085 inhibits the reaction [acenaphthenequinone results in increased expression of PTGS2 protein]PMID:17082565
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