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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionEXP 6480464CTDOzone results in increased expression of PTGS2 mRNA; Ozone results in increased expression of PTGS2 proteinPMID:22155309 PMID:22727909 PMID:23805001
Ptgs2multiple interactionsEXP 6480464CTD[Ozone co-treated with Particulate Matter] results in increased expression of PTGS2 mRNAPMID:23805001
Ptgs2decreases activityISOPTGS2 (Homo sapiens)6480464CTDOzone results in decreased activity of PTGS2 proteinPMID:9176252
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDOzone results in increased expression of PTGS2 mRNAPMID:24862973 PMID:24928893 PMID:26719369 PMID:27206323 PMID:31476115 PMID:34718810
Ptgs2increases expressionISOPtgs2 (Mus musculus)6480464CTDOzone results in increased expression of PTGS2 mRNA; Ozone results in increased expression of PTGS2 proteinPMID:15064226 PMID:18926814 PMID:21543283 PMID:26342085 PMID:30848106
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTD[Aripiprazole co-treated with Ozone] results in increased expression of PTGS2 mRNA; ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of PTGS2 mRNA]PMID:24862973 PMID:31476115
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTDindole-5-carboxamide inhibits the reaction [Ozone results in increased expression of PTGS2 mRNA]; NFKB1 gene mutant form inhibits the reaction [Ozone results in increased expression of PTGS2 protein]; TTPA protein affects the reaction [Ozone results in increased expression of PTGS2 mRNA]PMID:15064226 PMID:18926814 PMID:19555225
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