GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ptgs2 | increases expression | EXP | | 6480464 | CTD | Ozone results in increased expression of PTGS2 mRNA; Ozone results in increased expression of PTGS2 protein | PMID:22155309 PMID:22727909 PMID:23805001 | Ptgs2 | multiple interactions | EXP | | 6480464 | CTD | [Ozone co-treated with Particulate Matter] results in increased expression of PTGS2 mRNA | PMID:23805001 | Ptgs2 | decreases activity | ISO | PTGS2 (Homo sapiens) | 6480464 | CTD | Ozone results in decreased activity of PTGS2 protein | PMID:9176252 | Ptgs2 | increases expression | ISO | PTGS2 (Homo sapiens) | 6480464 | CTD | Ozone results in increased expression of PTGS2 mRNA | PMID:24862973 PMID:24928893 PMID:26719369 PMID:27206323 PMID:31476115 PMID:34718810 | Ptgs2 | increases expression | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | Ozone results in increased expression of PTGS2 mRNA; Ozone results in increased expression of PTGS2 protein | PMID:15064226 PMID:18926814 PMID:21543283 PMID:26342085 PMID:30848106 | Ptgs2 | multiple interactions | ISO | PTGS2 (Homo sapiens) | 6480464 | CTD | [Aripiprazole co-treated with Ozone] results in increased expression of PTGS2 mRNA; ferric ammonium citrate inhibits the reaction [Ozone results in increased expression of PTGS2 mRNA] | PMID:24862973 PMID:31476115 | Ptgs2 | multiple interactions | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | indole-5-carboxamide inhibits the reaction [Ozone results in increased expression of PTGS2 mRNA]; NFKB1 gene mutant form inhibits the reaction [Ozone results in increased expression of PTGS2 protein]; TTPA protein affects the reaction [Ozone results in increased expression of PTGS2 mRNA] | PMID:15064226 PMID:18926814 PMID:19555225 | |
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