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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:17243
Term: mono(2-ethylhexyl) phthalate
Definition: The mono(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:C016599
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2decreases expressionEXP 6480464CTDmono-(2-ethylhexyl)phthalate results in decreased expression of PTGS2 mRNA; mono-(2-ethylhexyl)phthalate results in decreased expression of PTGS2 proteinPMID:36889213
Ptgs2multiple interactionsEXP 6480464CTD[PTGS2 protein co-treated with mono-(2-ethylhexyl)phthalate] results in decreased expression of GNAS protein; PTGS2 protein inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of HAS2 mRNA]; PTGS2 protein inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of PRKACA mRNA]; PTGS2 protein inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of PTGER2 mRNA]; PTGS2 protein inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of PTGER2 protein]; PTGS2 protein inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of PTGER4 mRNA]; PTGS2 protein inhibits the reaction [mono-(2-ethylhexyl)phthalate results in decreased expression of PTGER4 protein]; PTGS2 protein inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of BAX mRNA]; PTGS2 protein inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of CASP3 protein]; PTGS2 protein inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of CASP7 protein]PMID:36889213
Ptgs2decreases expressionISOPTGS2 (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate results in decreased expression of PTGS2 mRNAPMID:29089286
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of PTGS2 mRNAPMID:23360888
Ptgs2increases expressionISOPtgs2 (Mus musculus)6480464CTDmono-(2-ethylhexyl)phthalate results in increased expression of PTGS2 mRNA; mono-(2-ethylhexyl)phthalate results in increased expression of PTGS2 proteinPMID:9013627
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD[mono-(2-ethylhexyl)phthalate co-treated with Genistein] results in increased expression of PTGS2 protein; Dexamethasone inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of PTGS2 mRNA]PMID:34942354 PMID:9013627
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