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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2decreases expressionISOPTGS2 (Homo sapiens)6480464CTDochratoxin A results in decreased expression of PTGS2 mRNAPMID:26505656
Ptgs2increases expressionISOPtgs2 (Mus musculus)6480464CTDochratoxin A results in increased expression of PTGS2 mRNA; ochratoxin A results in increased expression of PTGS2 proteinPMID:18647641 PMID:23172667
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTD[ochratoxin A co-treated with Citrinin] results in decreased expression of PTGS2 mRNA; [ochratoxin A co-treated with Citrinin] results in decreased expression of PTGS2 proteinPMID:29673704
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTDochratoxin A inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; ochratoxin A promotes the reaction [FOS protein binds to PTGS2 promoter]; ochratoxin A promotes the reaction [RELA protein binds to PTGS2 promoter]PMID:18647641 PMID:23172667
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