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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:34714
Term: dimethoate
Definition: A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.
Chemical ID: MESH:D004117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionEXP 6480464CTDDimethoate results in increased expression of PTGS2 proteinPMID:19579042 PMID:22476691
Ptgs2multiple interactionsEXP 6480464CTD[Dimethoate co-treated with Eicosapentaenoic Acid] results in increased expression of PTGS2 protein; Docosahexaenoic Acids inhibits the reaction [Dimethoate results in increased expression of PTGS2 protein]; docosapentaenoic acid inhibits the reaction [Dimethoate results in increased expression of PTGS2 protein]PMID:22476691
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