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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:7476
Term: naproxen
Definition: A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.
Chemical ID: MESH:D009288
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2decreases activityEXP 6480464CTDNaproxen results in decreased activity of PTGS2 proteinPMID:9258749
Ptgs2decreases activityISOPTGS2 (Homo sapiens)6480464CTDNaproxen results in decreased activity of PTGS2 proteinPMID:17164136
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDNaproxen results in increased expression of PTGS2PMID:11840453
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTDNaproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Naproxen inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; tert-Butylhydroperoxide inhibits the reaction [Naproxen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]PMID:15489888 PMID:15705740
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