Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	620349
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Ptgs2
Name:	prostaglandin-endoperoxide synthase 2

Acc ID:	CHEBI:76400
Term:	5-(N,N-hexamethylene)amiloride
Definition:	A member of the class of pyrazines that is amiloride in which the two amino hydrogens at position N-5 are replaced by a hexamethylene moiety, resulting in the formation of an azepane ring.
Chemical ID:	MESH:C057360

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Ptgs2	increases expression	ISO	RGD:731006	6480464	CTD	5-(N,N-hexamethylene)amiloride results in increased expression of PTGS2 mRNA	PMID:19302589

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