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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:50182
Term: 3,3'-diindolylmethane
Definition: An indole that has formula C17H14N2.
Chemical ID: MESH:C016392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2decreases expressionISOPTGS2 (Homo sapiens)6480464CTD3,3'-diindolylmethane results in decreased expression of PTGS2 mRNA; 3,3'-diindolylmethane results in decreased expression of PTGS2 proteinPMID:19056653 PMID:22290291
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTD3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTGS2 promoter]]; 3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; 3,3'-diindolylmethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 protein]PMID:19056653
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD3,3'-diindolylmethane inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]PMID:24162184
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