PROSTANOID BIOSYNTHETIC PATHWAY (PW:0001243)

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Description

Phospholipid derived arachidonic acid can be metabolized via three routes to give rise to a wide range of metabolites collectively referred to as eicosanoids. Of these, the members of the prostanoid subclass are derived from the prostaglandin H2 (PGH2) precursor generated in the cyclooxygenase mediated pathway of arachidonic acid metabolism (lipooxygenases and cytochrome P450 monooxygenases mediate the other two routes to produce leukotriene and other metabolites). The prostanoids bind to and

Pathway Diagram:

Elsevier Inc. PGG2 PGG2 ---> PGH2 Ptgs2 Ptgs1 arachidonic acid ---> PGG2 TXA2 PGF2alpha PGI2 PGE2 PGD2 PGH2 arachidonic acid Ptges2 Ptges3 Ptges Tbxas1 Cbr1 Akr1c3 Akr1b1 Akr1a1 Ptgis Ptgds Hpgds thromboxane A2 signaling pathway prostaglandin F2alpha signaling pathway prostaglandin I2 signaling pathway prostaglandin E2 signaling pathway prostaglandin D2 signaling pathway PGH2 ---> PGD2 PGI2 ---> cardiovascular functions PGE2 ---> inflammatory response PGE2 ---> perception of pain PGE2 ---> cardiovascular functions PGE2 ---> immunomodulation TXA2 ---> cardiovascular functions reproduction PGF2alpha ---> reproduction PGD2 ---> inflammatory response PGD2 ---> immunomodulation immunomodulation inflammatory response perception of pain cardiovascular functions PGH2 ---> TXA2 PGH2 ---> PGE2 PGH2 ---> PGF2alpha PGD2 ---> PGF2alpha PGE2 ---> PGF2alpha Fam213b PGH2 ---> PGI2 cyclooxygenase mediated pathway of arachidonic acid metabolism
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Genes in Pathway:

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prostanoid biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:8552701
RGD:8552712
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:8552701
RGD:8552712
prostacyclin biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptgis prostaglandin I2 synthase JBrowse link 3 163,950,746 163,986,129 RGD:8552712
prostaglandin biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1a1 aldo-keto reductase family 1 member A1 JBrowse link 5 135,482,068 135,498,693 RGD:8552778
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link 4 61,706,866 61,720,959 RGD:8552778
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:8552774
G Cbr1 carbonyl reductase 1 JBrowse link 11 33,813,041 33,815,418 RGD:8552774
G Fam213b family with sequence similarity 213, member B JBrowse link 5 172,304,799 172,307,402 RGD:8552775
G Hpgds hematopoietic prostaglandin D synthase JBrowse link 4 95,945,356 95,970,666 RGD:8552701
RGD:8552712
G Ptgds prostaglandin D2 synthase JBrowse link 3 2,686,125 2,689,059 RGD:8552701
RGD:8552712
G Ptges prostaglandin E synthase JBrowse link 3 9,727,408 9,738,752 RGD:8552701
RGD:8552712
G Ptges2 prostaglandin E synthase 2 JBrowse link 3 11,424,195 11,431,379 RGD:8552701
RGD:8552712
G Ptges3 prostaglandin E synthase 3 JBrowse link 7 2,479,267 2,497,024 RGD:8552701
RGD:8552712
thromboxane biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tbxas1 thromboxane A synthase 1 JBrowse link 4 66,624,181 66,846,745 RGD:8552712

Pathway Gene Annotations

Disease Annotations Associated with Genes in the prostanoid biosynthetic pathway
Disease TermsGene Symbols
Colitis, UlcerativePtgs1 , Ptgs2
Pathway Annotations Associated with Genes in the prostanoid biosynthetic pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayPtgs1 , Ptgs2
antipyrine drug pathwayPtgs1 , Ptgs2
arachidonic acid metabolic pathwayPtgs1 , Ptgs2
celecoxib pharmacodynamics pathwayPtgs1 , Ptgs2
celecoxib pharmacokinetics pathwayPtgs1 , Ptgs2
cyclooxygenase mediated pathway of arachidonic acid metabolismPtgs1 , Ptgs2
diclofenac pharmacodynamics pathwayPtgs1 , Ptgs2
diflunisal pharmacodynamics pathwayPtgs1 , Ptgs2
electron transport chain pathwayPtgs1
etodolac pharmacodynamics pathwayPtgs1 , Ptgs2
etoposide pharmacodynamics pathwayPtgs1 , Ptgs2
etoposide pharmacokinetics pathwayPtgs1 , Ptgs2
fenoprofen pharmacodynamics pathwayPtgs1 , Ptgs2
flurbiprofen pharmacodynamics pathwayPtgs1 , Ptgs2
ibuprofen pharmacodynamics pathwayPtgs1 , Ptgs2
ibuprofen pharmacokinetics pathwayPtgs1 , Ptgs2
indometacin pharmacodynamics pathwayPtgs1 , Ptgs2
indometacin pharmacodynamics pathwayPtgs1 , Ptgs2
ketoprofen pharmacodynamics pathwayPtgs1 , Ptgs2
ketorolac pharmacodynamics pathwayPtgs1 , Ptgs2
Leishmania infection pathwayPtgs2
leukotriene C4 synthase deficiency pathwayPtgs1 , Ptgs2
lornoxicam pharmacodynamics pathwayPtgs1 , Ptgs2
magnesium salicylate pharmacodynamics pathwayPtgs1 , Ptgs2
mefenamic acid pharmacodynamics pathwayPtgs1 , Ptgs2
meloxicam pharmacodynamics pathwayPtgs1 , Ptgs2
nabumetone pharmacodynamics pathwayPtgs1 , Ptgs2
naproxen pharmacodynamics pathwayPtgs1 , Ptgs2
paracetamol drug pathwayPtgs1 , Ptgs2
piroxicam pharmacodynamics pathwayPtgs1 , Ptgs2
prostanoid biosynthetic pathwayPtgs1 , Ptgs2
salicylic acid pharmacodynamics pathwayPtgs1 , Ptgs2
small cell lung cancer pathwayPtgs2
sodium salicylate pharmacodynamics pathwayPtgs1 , Ptgs2
sphingosine 1-phosphate signaling pathwayPtgs2
sulindac pharmacodynamics pathwayPtgs1 , Ptgs2
tenoxicam pharmacodynamics pathwayPtgs1 , Ptgs2
tiaprofenic acid pharmacodynamics pathwayPtgs1 , Ptgs2
tolmetin pharmacodynamics pathwayPtgs1 , Ptgs2
valdecoxib pharmacodynamics pathwayPtgs1 , Ptgs2
vascular endothelial growth factor signaling pathwayPtgs2

References Associated with the prostanoid biosynthetic pathway:

Ontology Path Diagram:

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