PROSTANOID BIOSYNTHETIC PATHWAY (PW:0001243)

View Ontology Report

Description

Phospholipid derived arachidonic acid can be metabolized via three routes to give rise to a wide range of metabolites collectively referred to as eicosanoids. Of these, the members of the prostanoid subclass are derived from the prostaglandin H2 (PGH2) precursor generated in the cyclooxygenase mediated pathway of arachidonic acid metabolism (lipooxygenases and cytochrome P450 monooxygenases mediate the other two routes to produce leukotriene and other metabolites). The prostanoids bind to and

Pathway Diagram:

Elsevier Inc. PGG2 PGG2 ---> PGH2 Ptgs2 Ptgs1 arachidonic acid ---> PGG2 TXA2 PGF2alpha PGI2 PGE2 PGD2 PGH2 arachidonic acid Ptges2 Ptges3 Ptges Tbxas1 Cbr1 Akr1c3 Akr1b1 Akr1a1 Ptgis Ptgds Hpgds thromboxane A2 signaling pathway prostaglandin F2alpha signaling pathway prostaglandin I2 signaling pathway prostaglandin E2 signaling pathway prostaglandin D2 signaling pathway PGH2 ---> PGD2 PGI2 ---> cardiovascular functions PGE2 ---> inflammatory response PGE2 ---> perception of pain PGE2 ---> cardiovascular functions PGE2 ---> immunomodulation TXA2 ---> cardiovascular functions reproduction PGF2alpha ---> reproduction PGD2 ---> inflammatory response PGD2 ---> immunomodulation immunomodulation inflammatory response perception of pain cardiovascular functions PGH2 ---> TXA2 PGH2 ---> PGE2 PGH2 ---> PGF2alpha PGD2 ---> PGF2alpha PGE2 ---> PGF2alpha Fam213b PGH2 ---> PGI2 cyclooxygenase mediated pathway of arachidonic acid metabolism
GO TO:

Genes in Pathway:

show annotations for term's descendants       view all columns           Sort by:
 
prostanoid biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:8552701
RGD:8552712
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:8552701
RGD:8552712
prostacyclin biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptgis prostaglandin I2 synthase JBrowse link 3 163,950,746 163,986,129 RGD:8552712
prostaglandin biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1a1 aldo-keto reductase family 1 member A1 JBrowse link 5 135,482,068 135,498,693 RGD:8552778
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link 4 61,706,866 61,720,959 RGD:8552778
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:8552774
G Cbr1 carbonyl reductase 1 JBrowse link 11 33,813,041 33,815,418 RGD:8552774
G Fam213b family with sequence similarity 213, member B JBrowse link 5 172,304,799 172,307,402 RGD:8552775
G Hpgds hematopoietic prostaglandin D synthase JBrowse link 4 95,945,356 95,970,666 RGD:8552701
RGD:8552712
G Ptgds prostaglandin D2 synthase JBrowse link 3 2,686,125 2,689,059 RGD:8552701
RGD:8552712
G Ptges prostaglandin E synthase JBrowse link 3 9,727,408 9,738,752 RGD:8552701
RGD:8552712
G Ptges2 prostaglandin E synthase 2 JBrowse link 3 11,424,195 11,431,379 RGD:8552701
RGD:8552712
G Ptges3 prostaglandin E synthase 3 JBrowse link 7 2,479,267 2,497,024 RGD:8552701
RGD:8552712
thromboxane biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tbxas1 thromboxane A synthase 1 JBrowse link 4 66,624,181 66,846,745 RGD:8552712

Pathway Gene Annotations

Disease Annotations Associated with Genes in the prostanoid biosynthetic pathway
Disease TermsGene Symbols
abdominal aortic aneurysmPtgs2
acute kidney failurePtgs2
Acute Liver FailurePtgs2
Acute Lung InjuryPtgs2
adenocarcinomaPtgs2
Adrenal Gland NeoplasmsPtgs2
AlbuminuriaPtgs2
Alcohol Withdrawal DeliriumPtgs2
Alzheimer's diseasePtgs1 , Ptgs2
amyotrophic lateral sclerosisPtgs2
AnaphylaxisPtgs1 , Ptgs2
Aortic Valve, Calcification ofPtgs2
arteriosclerosisPtgs2
asphyxia neonatorumPtgs2
Aspirin-Induced AsthmaPtgs2
asthmaPtgs2
Asthma, OccupationalPtgs1 , Ptgs2
atherosclerosisPtgs2
autistic disorderPtgs2
avian influenzaPtgs2
B-cell lymphomaPtgs2
Barrett's esophagusPtgs2
bipolar disorderPtgs1 , Ptgs2
bladder neck obstructionPtgs2
Bone FracturesPtgs2
Bone NeoplasmsPtgs2
Brain InjuriesPtgs1 , Ptgs2
brain ischemiaPtgs1 , Ptgs2
Breast NeoplasmsPtgs1 , Ptgs2
Bronchial HyperreactivityPtgs1
BurnsPtgs2
CachexiaPtgs2
carcinomaPtgs1 , Ptgs2
Cardiac ArrhythmiasPtgs2
cardiomyopathyPtgs2
cardiovascular system diseasePtgs2
Cerebral HemorrhagePtgs2
cervix uteri carcinoma in situPtgs2
Chemical and Drug Induced Liver InjuryPtgs2
cholangiocarcinomaPtgs2
Chronic Lymphocytic Leukemia, B-CellPtgs2
chronic obstructive pulmonary diseasePtgs2
Cognition DisordersPtgs2
colitisPtgs2
Colonic NeoplasmsPtgs2
Colorectal NeoplasmsPtgs2
congestive heart failurePtgs1 , Ptgs2
coronary artery diseasePtgs2
CoughPtgs2
Creutzfeldt-Jakob diseasePtgs1 , Ptgs2
Crohn's diseasePtgs2
cryptorchidismPtgs2
cystic fibrosisPtgs2
cystitisPtgs2
demyelinating diseasePtgs2
diabetes mellitusPtgs2
Diabetic NephropathiesPtgs2
diabetic neuropathyPtgs2
disease of cellular proliferationPtgs2
drug allergyPtgs1
Drug-Related Side Effects and Adverse ReactionsPtgs2
ductal carcinoma in situPtgs2
duodenal ulcerPtgs2
EdemaPtgs2
end stage renal failurePtgs1 , Ptgs2
Endometrial NeoplasmsPtgs1 , Ptgs2
endometriosisPtgs2
EndotoxemiaPtgs2
Esophageal NeoplasmsPtgs1 , Ptgs2
esophagitisPtgs2
esophagus adenocarcinomaPtgs2
esophagus squamous cell carcinomaPtgs2
Experimental ArthritisPtgs1 , Ptgs2
Experimental Autoimmune EncephalomyelitisPtgs1 , Ptgs2
Experimental Autoimmune NeuritisPtgs1 , Ptgs2
Experimental Diabetes MellitusPtgs1 , Ptgs2
Experimental Liver CirrhosisPtgs1 , Ptgs2
familial adenomatous polyposisPtgs2
fatty liver diseasePtgs2
Fetal Growth RetardationPtgs2
FeverPtgs2
FibrosisPtgs2
FlushingPtgs1
Gallbladder NeoplasmsPtgs2
gastric ulcerPtgs1 , Ptgs2
gastritisPtgs2
gastroesophageal reflux diseasePtgs2
glaucomaPtgs1
glioblastoma multiformePtgs1 , Ptgs2
gliosarcomaPtgs1 , Ptgs2
granulosa cell tumorPtgs2
Graves OphthalmopathyPtgs2
growth hormone secreting pituitary adenomaPtgs2
head and neck squamous cell carcinomaPtgs2
hepatic encephalopathyPtgs1
hepatocellular carcinomaPtgs2
human immunodeficiency virus infectious diseasePtgs2
Human InfluenzaPtgs2
Huntington's diseasePtgs2
hydronephrosisPtgs2
HyperalgesiaPtgs1 , Ptgs2
HyperemiaPtgs2
hyperglycemiaPtgs2
HyperplasiaPtgs2
hypertensionPtgs2
Hypertrophy, Left VentricularPtgs2
HypoxiaPtgs2
idiopathic pulmonary fibrosisPtgs2
in situ carcinomaPtgs2
InflammationPtgs2
inflammatory bowel diseasePtgs2
intestinal obstructionPtgs2
Intestinal PolypsPtgs1 , Ptgs2
invasive ductal carcinomaPtgs2
kidney diseasePtgs2
Kidney NeoplasmsPtgs2
Laryngeal NeoplasmsPtgs2
Laryngeal PapillomatosisPtgs2
leiomyosarcomaPtgs2
lung diseasePtgs2
Lung NeoplasmsPtgs2
Lymphatic MetastasisPtgs2
malignant gliomaPtgs2
Mammary Neoplasms, ExperimentalPtgs2
melanomaPtgs2
mental depressionPtgs2
Metabolic SyndromePtgs2
mouth diseasePtgs2
Mouth NeoplasmsPtgs2
myocardial infarctionPtgs2
Myocardial Reperfusion InjuryPtgs2
myocarditisPtgs2
Nasal PolypsPtgs1 , Ptgs2
Neoplasm MetastasisPtgs2
Neoplasm Recurrence, LocalPtgs2
nephroblastomaPtgs2
nephrotic syndromePtgs2
nervous system diseasePtgs2
Neurogenic InflammationPtgs2
non-small cell lung carcinomaPtgs2
obesityPtgs2
obstructive sleep apneaPtgs2
open-angle glaucomaPtgs2
oral mucosa leukoplakiaPtgs2
oral submucous fibrosisPtgs2
osteoarthritisPtgs2
ovarian cystPtgs1
Ovarian NeoplasmsPtgs1 , Ptgs2
PainPtgs1 , Ptgs2
pancreatic cancerPtgs2
pancreatic ductal carcinomaPtgs2
pancreatitisPtgs2
papillomaPtgs2
Parkinsonian DisordersPtgs2
Perennial Allergic RhinitisPtgs1
pericardial effusionPtgs2
Peripheral Nerve InjuriesPtgs1 , Ptgs2
pleurisyPtgs2
Polycystic Kidney DiseasesPtgs1 , Ptgs2
portal hypertensionPtgs2
pre-eclampsiaPtgs1
pre-malignant neoplasmPtgs2
Premature BirthPtgs2
prolactinomaPtgs2
prostate cancerPtgs2
prostate carcinoma in situPtgs2
prostatic hypertrophyPtgs2
Prostatic NeoplasmsPtgs2
prostatitisPtgs2
proteinuriaPtgs2
Puberty, PrecociousPtgs2
pulmonary emphysemaPtgs2
pulmonary fibrosisPtgs2
pulmonary hypertensionPtgs2
Radiation Injuries, ExperimentalPtgs1 , Ptgs2
renal cell carcinomaPtgs1 , Ptgs2
renovascular hypertensionPtgs1
Reperfusion InjuryPtgs1 , Ptgs2
retrograde amnesiaPtgs2
rheumatoid arthritisPtgs1 , Ptgs2
sarcoidosisPtgs2
schizophreniaPtgs2
Seasonal Allergic RhinitisPtgs1
secondary hyperparathyroidismPtgs2
skin diseasePtgs2
Skin NeoplasmsPtgs2
Sleep DeprivationPtgs1 , Ptgs2
Spinal Cord InjuriesPtgs1 , Ptgs2
squamous cell carcinomaPtgs2
status epilepticusPtgs2
Stomach NeoplasmsPtgs2
StrokePtgs2
Subarachnoid HemorrhagePtgs2
systemic lupus erythematosusPtgs2
systemic sclerodermaPtgs2
thrombosisPtgs2
Thyroid NeoplasmsPtgs2
Tongue NeoplasmsPtgs2
transitional cell carcinomaPtgs2
type 2 diabetes mellitusPtgs2
urinary bladder cancerPtgs2
Urologic NeoplasmsPtgs2
Uterine Cervical NeoplasmsPtgs1 , Ptgs2
Ventilator-Induced Lung InjuryPtgs2
visual epilepsyPtgs2
Wernicke encephalopathyPtgs2
Pathway Annotations Associated with Genes in the prostanoid biosynthetic pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayPtgs1 , Ptgs2
antipyrine drug pathwayPtgs1 , Ptgs2
arachidonic acid metabolic pathwayPtgs1 , Ptgs2
celecoxib pharmacodynamics pathwayPtgs1 , Ptgs2
celecoxib pharmacokinetics pathwayPtgs1 , Ptgs2
cyclooxygenase mediated pathway of arachidonic acid metabolismPtgs1 , Ptgs2
diclofenac pharmacodynamics pathwayPtgs1 , Ptgs2
diflunisal pharmacodynamics pathwayPtgs1 , Ptgs2
etodolac pharmacodynamics pathwayPtgs1 , Ptgs2
etoposide pharmacodynamics pathwayPtgs1 , Ptgs2
etoposide pharmacokinetics pathwayPtgs1 , Ptgs2
fenoprofen pharmacodynamics pathwayPtgs1 , Ptgs2
flurbiprofen pharmacodynamics pathwayPtgs1 , Ptgs2
ibuprofen pharmacodynamics pathwayPtgs1 , Ptgs2
ibuprofen pharmacokinetics pathwayPtgs1 , Ptgs2
indometacin pharmacodynamics pathwayPtgs1 , Ptgs2
indometacin pharmacodynamics pathwayPtgs1 , Ptgs2
ketoprofen pharmacodynamics pathwayPtgs1 , Ptgs2
ketorolac pharmacodynamics pathwayPtgs1 , Ptgs2
Leishmaniasis pathwayPtgs2
leukotriene C4 synthase deficiency pathwayPtgs1 , Ptgs2
lornoxicam pharmacodynamics pathwayPtgs1 , Ptgs2
magnesium salicylate pharmacodynamics pathwayPtgs1 , Ptgs2
mefenamic acid pharmacodynamics pathwayPtgs1 , Ptgs2
meloxicam pharmacodynamics pathwayPtgs1 , Ptgs2
nabumetone pharmacodynamics pathwayPtgs1 , Ptgs2
naproxen pharmacodynamics pathwayPtgs1 , Ptgs2
paracetamol drug pathwayPtgs1 , Ptgs2
piroxicam pharmacodynamics pathwayPtgs1 , Ptgs2
prostanoid biosynthetic pathwayPtgs1 , Ptgs2
salicylic acid pharmacodynamics pathwayPtgs1 , Ptgs2
small cell lung carcinoma pathwayPtgs2
sodium salicylate pharmacodynamics pathwayPtgs1 , Ptgs2
sphingosine 1-phosphate signaling pathwayPtgs2
sulindac pharmacodynamics pathwayPtgs1 , Ptgs2
tenoxicam pharmacodynamics pathwayPtgs1 , Ptgs2
tiaprofenic acid pharmacodynamics pathwayPtgs1 , Ptgs2
tolmetin pharmacodynamics pathwayPtgs1 , Ptgs2
valdecoxib pharmacodynamics pathwayPtgs1 , Ptgs2
vascular endothelial growth factor signaling pathwayPtgs2

References Associated with the prostanoid biosynthetic pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: