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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:167729
Term: Methanandamide
Definition: null
Chemical ID: MESH:C088155
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDmethanandamide results in increased expression of PTGS2 mRNA; methanandamide results in increased expression of PTGS2 proteinPMID:11527419 PMID:16330497
Ptgs2increases response to substanceISOPTGS2 (Homo sapiens)6480464CTDPTGS2 results in increased susceptibility to methanandamidePMID:15361550
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[methanandamide results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [methanandamide results in increased expression of PTGS2 mRNA]; [methanandamide results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone; IL1B promotes the reaction [methanandamide results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [[methanandamide results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]; SB 203580 inhibits the reaction [methanandamide results in increased expression of PTGS2 mRNA]PMID:11527419 PMID:16330497
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