RGD Reference Report - [Prognostic significance of cyclooxygenase (COX-1 and COX-2) expression in endometrial carcinoma (clinical and immunohistochemical study)] - Rat Genome Database

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[Prognostic significance of cyclooxygenase (COX-1 and COX-2) expression in endometrial carcinoma (clinical and immunohistochemical study)]

Authors: Boldarian, NA  Pozharisskii, KM  Vinokurov, VL  Ten, VP  Samsonova, EA 
Citation: Boldarian NA, etal., Vopr Onkol. 2008;54(1):40-6.
RGD ID: 2300125
Pubmed: PMID:18416056   (View Abstract at PubMed)

An immunohistochemical study of 100 endometrial adenocarcinomas assessed expression of COX-1 (40%) and COX-2 (72%) cyclooxygenases. An inverse correlation between COX-2 expression and tumor cell differentiation was matched by a direct one between COX-2 expression and survival. In cases of no expression, overall relapse-free 5-year survival was 92 and 88%, respectively, while distinct expression was associated with 52 and 48%, respectively (p = 0.0004; 0.0005). Similar relationships were reported for COX-1, although the significance was lower (p = 0.02). Since the differences in survival vis-a-vis clinico-morphological features were insignificant, except for COX-1, COX-2 expression, the latter characteristics should be regarded as independent prognosticators, much more superior to such traditional factors as stage and cell differentiation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
endometrial carcinoma disease_progressionIEP 2300125 RGD 
endometrial carcinoma disease_progressionISOPTGS1 (Homo sapiens)2300125; 2300125 RGD 
Endometrial Neoplasms disease_progressionIEP 2300125 RGD 
Endometrial Neoplasms disease_progressionISOPTGS2 (Homo sapiens)2300125; 2300125 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptgs1  (prostaglandin-endoperoxide synthase 1)
Ptgs2  (prostaglandin-endoperoxide synthase 2)

Genes (Mus musculus)
Ptgs1  (prostaglandin-endoperoxide synthase 1)
Ptgs2  (prostaglandin-endoperoxide synthase 2)

Genes (Homo sapiens)
PTGS1  (prostaglandin-endoperoxide synthase 1)
PTGS2  (prostaglandin-endoperoxide synthase 2)


Additional Information