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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2affects expressionEXP 6480464CTDAtrazine affects the expression of PTGS2PMID:21726175
Ptgs2increases expressionEXP 6480464CTDAtrazine results in increased expression of PTGS2 mRNAPMID:22372587 PMID:34663174
Ptgs2multiple interactionsEXP 6480464CTDkolaviron inhibits the reaction [Atrazine affects the expression of PTGS2]; Quercetin inhibits the reaction [Atrazine results in increased expression of PTGS2 mRNA]PMID:21726175 PMID:22372587
Ptgs2increases expressionISOPtgs2 (Mus musculus)6480464CTDAtrazine results in increased expression of PTGS2 mRNAPMID:36216167
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTDLycopene inhibits the reaction [Atrazine results in increased expression of PTGS2 mRNA]PMID:36216167
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