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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:28112
Term: nickel atom
Definition: Chemical element (nickel group element atom) with atomic number 28.
Chemical ID: MESH:D009532
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDNickel results in increased expression of PTGS2; Nickel results in increased expression of PTGS2 mRNAPMID:21486220 PMID:24768652 PMID:25583101
Ptgs2increases expressionISOPtgs2 (Mus musculus)6480464CTDNickel analog results in increased expression of PTGS2 protein; Nickel results in increased expression of PTGS2 mRNA; Nickel results in increased expression of PTGS2 proteinPMID:19839048 PMID:22571318 PMID:27452194
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTDCAT protein affects the reaction [Nickel results in increased expression of PTGS2]; NFATC4 mRNA affects the reaction [Nickel results in increased expression of PTGS2]PMID:21486220
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTDDexamethasone inhibits the reaction [Nickel results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Nickel results in increased expression of PTGS2 mRNA]PMID:19839048
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