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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:28984
Term: aluminium atom
Definition: A boron group element atom that has formula Al.
Chemical ID: MESH:D000535
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionISOPtgs2 (Mus musculus)6480464CTDAluminum results in increased expression of PTGS2 mRNA; Aluminum results in increased expression of PTGS2 proteinPMID:16928369
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 mRNA]; Meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 protein]PMID:16928369 PMID:23690655
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