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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:6498
Term: lipoxin A4
Definition: A C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds.
Chemical ID: MESH:C040527
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2affects abundanceEXP 6480464CTDPTGS2 protein affects the abundance of lipoxin A4

PMID:15326064
Ptgs2multiple interactionsEXP 6480464CTD[lipoxin A4 co-treated with lipopolysaccharide E coli O55-B5] results in increased expression of PTGS2 protein Celecoxib inhibits the reaction [PTGS2 protein affects the abundance of lipoxin A4] lipoxin A4 inhibits the reaction [lipopolysaccharide E coli O55-B5 results in increased expression of PTGS2 protein]

PMID:15326064 PMID:21765620
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