RGD Reference Report - [Cyclooxygenase (COX)-2 expression in a rat duodenoesophageal reflux model and chemoprevention of adenocarcinoma by the selective COX-2 inhibitor nimesulide] - Rat Genome Database

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[Cyclooxygenase (COX)-2 expression in a rat duodenoesophageal reflux model and chemoprevention of adenocarcinoma by the selective COX-2 inhibitor nimesulide]

Authors: Oyama, K  Fujimura, T  Ninomiya, I  Miyashita, T  Kinami, S  Fushida, S  Ohta, T 
Citation: Oyama K, etal., Nippon Shokakibyo Gakkai Zasshi. 2007 Aug;104(8):1183-91.
RGD ID: 1642603
Pubmed: PMID:17675820   (View Abstract at PubMed)

The aim of this study is to investigate the cyclooxygenase (COX)-2 expression in esophageal epithelium of rat duodenoesophageal reflux model and the effect of a selective COX-2 inhibitor on esophageal adenocarcinogenesis in rats. A series of rats underwent a duodenoesophageal reflux procedure and were divided into 2 groups. One group was given commercial chow (control group), and the other group was given experimental chow containing nimesulide, a selective COX-2 inhibitor (nimesulide group). The animals were sacrificed sequentially after surgery and esophageal examinations were performed. In the control group, esophagitis, Barrett's esophagus (BE) and adenocarcinoma (EAC) were observed, and the frequency of these conditions increased with time. COX-2 expression, PGE(2) level and proliferative activity were up-regulated, predominantly in the inflamed esophageal epithelia, from the 10(th) week. In the nimesulide group, the esophagitis was mild and the frequency of BE was significantly lower than the control group, while EAC was not observed throughout the experiment. PGE(2) level and proliferative activity were lower in the nimesulide group than in the control group. COX-2 may play an important role in esophageal carcinogenesis through the activation of the inflammation-metaplasia-adenocarcinoma sequence. Nimesulide is effective in preventing BE and EAC by suppressing COX-2 activity.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTGS2Humanadenocarcinoma  ISOPtgs2 (Rattus norvegicus)associated with Esophageal NeoplasmsRGD 
Ptgs2Ratadenocarcinoma  IMP associated with Esophageal NeoplasmsRGD 
Ptgs2Mouseadenocarcinoma  ISOPtgs2 (Rattus norvegicus)associated with Esophageal NeoplasmsRGD 
PTGS2HumanBarrett's esophagus  ISOPtgs2 (Rattus norvegicus) RGD 
Ptgs2RatBarrett's esophagus  IMP  RGD 
Ptgs2MouseBarrett's esophagus  ISOPtgs2 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptgs2  (prostaglandin-endoperoxide synthase 2)

Genes (Mus musculus)
Ptgs2  (prostaglandin-endoperoxide synthase 2)

Genes (Homo sapiens)
PTGS2  (prostaglandin-endoperoxide synthase 2)


Additional Information