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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:28819
Term: naringin
Definition: A disaccharide derivative that is (S)-naringenin substituted by a 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.
Chemical ID: MESH:C005274
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2multiple interactionsEXP 6480464CTDnaringin inhibits the reaction [3-nitropropionic acid results in increased expression of PTGS2 mRNA]PMID:22871521
Ptgs2affects expressionISOPtgs2 (Mus musculus)6480464CTDnaringin affects the expression of PTGS2 mRNA; naringin affects the expression of PTGS2 proteinPMID:25117567
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTDnaringin inhibits the reaction [Acetaminophen results in increased expression of PTGS2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of PTGS2 protein]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]PMID:16137700 PMID:35166444 PMID:35179299 PMID:36811345
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