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Plasma membrane phospholipids are hydrolyzed to arachidonic acid and lysophospholipid through the action of phospholipase A2 (PLA2). The PLA2 enzymes are classified into the calcium-dependent secreted sPLA2 and cytosolic cPLA2 and the calcium independent iPLA2 categories and further divided into several groups and subgroups. PLA2s catalyze the release of fatty acids from the sn-2 position of phospholipids. Of the cPLA2s, the group IV-A member known as Pla2g4a, preferentially hydrolyzes membrane

Pathway Diagram:

Elsevier Inc. PGG2 ---> PGH2 Ptgs2 Mknk1 --+> Pla2g4a Mknk1 P-Ser indomethacin diclonefac meloxicam celecoxib paracetamol Pla2g4a ---- Vim Vim --+> Pla2g4a Pla2g4a Vim Ca2+ phospholipid hydrolysis Ca2+ ---- Pla2g4a Anxa1 ---- Pla2g4a Anxa1 ---| Pla2g4a Mknk1 ---> Pla2g4a paracetamol ---| Ptgs1 paracetamol ---| Ptgs2 Anxa1 lysophospholipid arachidonic acid PGG2 PGH2 arachidonic acid ---> PGG2 prostanoid biosynthetic pathway ---> various responses elicited by signaling via prostanoids NSAIDs Ptgs1 selective Cox-2 inhibitors prostanoid biosynthetic pathway paracetamol ---| prostanoid biosynthetic pathway paracetamol drug pathway celecoxib ---| Ptgs2 indomethacin ---| Ptgs1 diclonefac ---| Ptgs1 various responses elicited by signaling via prostanoids phospholipids phospholipids ---> arachidonic acid phospholipids ---> lysophospholipid PGH2 --+> prostanoid biosynthetic pathway meloxicam ---| Ptgs2

Genes in Pathway:

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cyclooxygenase mediated pathway of arachidonic acid metabolism term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anxa1 annexin A1 JBrowse link 1 237,893,983 237,910,002 RGD:8552898
G Mknk1 MAP kinase-interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:8552898
G Pla2g4a phospholipase A2 group IVA JBrowse link 13 67,062,252 67,206,688 RGD:8552712
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:8552701
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:8552701
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:8552898
prostaglandin biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1a1 aldo-keto reductase family 1 member A1 JBrowse link 5 135,482,068 135,498,693 RGD:8552778
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link 4 61,706,866 61,720,959 RGD:8552778
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:8552774
G Cbr1 carbonyl reductase 1 JBrowse link 11 33,813,041 33,815,418 RGD:8552774
G Fam213b family with sequence similarity 213, member B JBrowse link 5 172,304,799 172,307,402 RGD:8552775
G Hpgds hematopoietic prostaglandin D synthase JBrowse link 4 95,945,356 95,970,666 RGD:8552701
G Ptgds prostaglandin D2 synthase JBrowse link 3 2,686,125 2,689,059 RGD:8552701
G Ptges prostaglandin E synthase JBrowse link 3 9,727,408 9,738,752 RGD:8552701
G Ptges2 prostaglandin E synthase 2 JBrowse link 3 11,424,195 11,431,379 RGD:8552701
G Ptges3 prostaglandin E synthase 3 JBrowse link 7 2,479,267 2,497,024 RGD:8552701

Pathway Gene Annotations

Disease Annotations Associated with Genes in the cyclooxygenase mediated pathway of arachidonic acid metabolism
Disease TermsGene Symbols
Acute Coronary SyndromeVim
Acute Kidney InjuryAnxa1 , Ptgs2
Acute Lung InjuryPtgs2
Adenocarcinoma of EsophagusPtgs2
Adenomatous Polyposis ColiPtgs2
adrenal gland neoplasmsPtgs2
adult respiratory distress syndromePla2g4a
Alcohol Withdrawal DeliriumPtgs2
Alzheimer DiseasePtgs1 , Ptgs2 , Vim
Amnesia, RetrogradePtgs2
amyotrophic lateral sclerosisPla2g4a , Ptgs2
amyotrophic lateral sclerosis type 1Vim
AnaphylaxisPtgs1 , Ptgs2
Aortic Aneurysm, AbdominalPtgs2
Aortic Valve, Calcification ofPtgs2
Arrhythmias, CardiacPtgs2
Arthritis, ExperimentalAnxa1 , Ptgs1 , Ptgs2 , Vim
Arthritis, RheumatoidPtgs1 , Ptgs2 , Vim
Asphyxia NeonatorumPtgs2
asthmaAnxa1 , Pla2g4a , Ptgs2
Asthma, Aspirin-InducedPtgs2
Asthma, OccupationalPla2g4a , Ptgs1 , Ptgs2
atherosclerosisPtgs2 , Vim
Autistic DisorderPla2g4a , Ptgs2
Barrett esophagusPtgs2
Behcet SyndromeVim
bipolar disorderPtgs1 , Ptgs2
Blood Platelet DisordersPla2g4a
Bone NeoplasmsPtgs2
Brain InjuriesPtgs1 , Ptgs2 , Vim
Brain IschemiaAnxa1 , Pla2g4a , Ptgs1 , Ptgs2
Breast NeoplasmsAnxa1 , Pla2g4a , Ptgs1 , Ptgs2 , Vim
Bronchial HyperreactivityPtgs1
BurnsPla2g4a , Ptgs2
CarcinomaAnxa1 , Ptgs1 , Ptgs2
Carcinoma in SituPtgs2
Carcinoma, Ductal, BreastAnxa1 , Ptgs2
Carcinoma, HepatocellularPtgs2
Carcinoma, Intraductal, NoninfiltratingAnxa1 , Ptgs2
Carcinoma, Renal CellAnxa1 , Ptgs1 , Ptgs2
Carcinoma, Squamous CellAnxa1 , Ptgs2
Carcinoma, Squamous Cell of Head and NeckPtgs2
Carcinoma, Transitional CellAnxa1 , Pla2g4a , Ptgs2
cardiovascular system diseasePtgs2
CataractAnxa1 , Vim
Cataract, Nuclear Diffuse NonprogressiveVim
Cell Transformation, NeoplasticVim
Cerebral HemorrhageAnxa1 , Ptgs2
Cerebral InfarctionAnxa1 , Vim
Cervical Intraepithelial NeoplasiaPtgs2
Chagas DiseaseVim
Chemical and Drug Induced Liver InjuryPtgs2 , Vim
Cognition DisordersPtgs2
ColitisAnxa1 , Ptgs2
Colonic NeoplasmsPtgs2
Colorectal NeoplasmsPtgs2
Coronary Artery DiseasePtgs2 , Vim
Craniofacial AbnormalitiesAnxa1
Creutzfeldt-Jakob SyndromePtgs1 , Ptgs2
Crohn DiseasePtgs2
Cystic FibrosisPtgs2
Darier DiseaseAnxa1
Demyelinating DiseasesPtgs2
Dermatitis, ContactAnxa1
Diabetes MellitusPtgs2
diabetes mellitus, experimentalAnxa1 , Ptgs1 , Ptgs2
Diabetic NephropathiesPtgs2
Diabetic NeuropathiesPtgs2
Disease Models, AnimalVim
Drug HypersensitivityPtgs1
Drug-Related Side Effects and Adverse ReactionsPtgs2
Dry Eye SyndromesAnxa1
Duodenal UlcerPla2g4a , Ptgs2
Endometrial NeoplasmsPtgs1 , Ptgs2
Esophageal NeoplasmsPtgs1 , Ptgs2
Esophageal Squamous Cell CarcinomaAnxa1 , Ptgs2
Experimental Encephalomyelitis, AutoimmuneAnxa1 , Ptgs1 , Ptgs2
Fatty LiverPtgs2
Fetal Growth RetardationPtgs2
FeverPla2g4a , Ptgs2 , Vim
Fractures, BonePtgs2
gallbladder neoplasmsPtgs2
Gastroesophageal RefluxPtgs2
Glaucoma, Open-AnglePtgs2
glioblastomaPtgs1 , Ptgs2
GliosarcomaPtgs1 , Ptgs2
Granulosa Cell TumorPtgs2
Graves OphthalmopathyPtgs2
Growth Hormone-Secreting Pituitary AdenomaPtgs2
Head Injuries, ClosedVim
Head Injuries, PenetratingVim
Heart FailurePtgs1 , Ptgs2
Hepatic EncephalopathyPtgs1
HIV InfectionsPtgs2
human influenzaPtgs2
Huntington DiseasePtgs2
HyperalgesiaAnxa1 , Pla2g4a , Ptgs1 , Ptgs2
HyperglycemiaPla2g4a , Ptgs2
Hyperparathyroidism, SecondaryPtgs2
Hypersensitivity, DelayedAnxa1
HypertensionAnxa1 , Ptgs2
Hypertension, RenovascularPtgs1
HyperthyroidismAnxa1 , Vim
Hypertrophy, Left VentricularPtgs2
Idiopathic Pulmonary FibrosisPtgs2
InflammationAnxa1 , Pla2g4a , Ptgs2
Inflammatory Bowel DiseasesPtgs2
influenza in birdsPtgs2
Intestinal ObstructionPtgs2
Intestinal PolypsPtgs1 , Ptgs2
Keratosis, SeborrheicAnxa1
Kidney DiseasesAnxa1 , Ptgs2
Kidney Failure, ChronicPtgs1 , Ptgs2
kidney neoplasmsPtgs2
Kidney Reperfusion InjuryAnxa1
Laryngeal NeoplasmsPtgs2
Laryngeal PapillomatosisPtgs2
Leukemia, Lymphocytic, Chronic, B-CellPtgs2
Leukoplakia, OralPtgs2
Liver CirrhosisVim
Liver Cirrhosis, ExperimentalAnxa1 , Pla2g4a , Ptgs1 , Ptgs2 , Vim
Liver Failure, AcutePtgs2
Liver Neoplasms, ExperimentalVim
lung adenocarcinomaAnxa1
Lung DiseasesPtgs2
Lung NeoplasmsPtgs2
Lupus Erythematosus, DiscoidAnxa1
Lupus Erythematosus, SystemicPtgs2 , Vim
Lymphatic MetastasisAnxa1 , Ptgs2
Lymphoma, B-CellPtgs2
Mammary Neoplasms, AnimalAnxa1
Mammary Neoplasms, ExperimentalAnxa1 , Ptgs2
mental depressionPtgs2
Mesothelioma, MalignantVim
Metabolic Syndrome XPla2g4a , Ptgs2
Metabolism, Inborn ErrorsPla2g4a
Motor Neuron DiseaseVim
Mouth DiseasesPtgs2
Mouth NeoplasmsAnxa1 , Ptgs2
Myocardial InfarctionPtgs2
Myocardial Reperfusion InjuryAnxa1 , Ptgs2
Nasal PolypsAnxa1 , Ptgs1 , Ptgs2
Neoplasm InvasivenessAnxa1 , Vim
Neoplasm MetastasisAnxa1 , Ptgs2 , Vim
Neoplasm Recurrence, LocalPtgs2
Nephrotic SyndromePtgs2
Nervous System DiseasesPtgs2
Neuritis, Autoimmune, ExperimentalAnxa1 , Ptgs1 , Ptgs2
Neurodegenerative DiseasesVim
Neurogenic InflammationPtgs2
non-small cell lung carcinomaPtgs2
Oral Submucous FibrosisPtgs2
OsteoarthritisPtgs2 , Vim
Ovarian CystsPtgs1
Ovarian NeoplasmsPtgs1 , Ptgs2
PainPtgs1 , Ptgs2
pancreatic ductal carcinomaPtgs2
Pancreatic NeoplasmsAnxa1 , Ptgs2
papillomaPla2g4a , Ptgs2
Paranasal Sinus NeoplasmsAnxa1
Parkinsonian DisordersPtgs2
perennial allergic rhinitisPtgs1
Pericardial EffusionPtgs2
Peripheral Nerve InjuriesPtgs1 , Ptgs2
Peritoneal NeoplasmsVim
Phospholipase A2, Group IVA, Deficiency ofPla2g4a
PleurisyAnxa1 , Ptgs2
Polycystic Kidney DiseasesPla2g4a , Ptgs1 , Ptgs2
portal hypertensionPtgs2
Precancerous ConditionsPtgs2
Premature BirthPtgs2
prostate cancerPtgs2
prostate carcinoma in situPtgs2
Prostatic HyperplasiaPtgs2
Prostatic NeoplasmsAnxa1 , Ptgs2 , Vim
Puberty, PrecociousPtgs2
Pulmonary Disease, Chronic ObstructivePtgs2
Pulmonary EmphysemaPtgs2
Pulmonary FibrosisAnxa1 , Ptgs2
pulmonary hypertensionPtgs2
Radiation Injuries, ExperimentalPtgs1 , Ptgs2
Reperfusion InjuryPla2g4a , Ptgs1 , Ptgs2 , Vim
Retinal DiseasesVim
Sarcoma, SynovialVim
Scleroderma, SystemicPtgs2
seasonal allergic rhinitisPtgs1
Sjogren's SyndromeVim
Skin DiseasesPtgs2
Skin NeoplasmsAnxa1 , Ptgs2
Sleep Apnea, ObstructivePtgs2
Sleep DeprivationPtgs1 , Ptgs2
Spinal Cord InjuriesAnxa1 , Ptgs1 , Ptgs2 , Vim
Status EpilepticusPtgs2
Stomach DiseasesAnxa1
Stomach NeoplasmsAnxa1 , Ptgs2
Stomach UlcerPtgs1 , Ptgs2
Subarachnoid HemorrhagePtgs2
Substance-Related DisordersMknk1
Thyroid NeoplasmsPtgs2
Tongue NeoplasmsPtgs2
Toxoplasmosis, OcularAnxa1
type 2 diabetes mellitusPtgs2
urinary bladder cancerPtgs2
Urinary Bladder Neck ObstructionPtgs2
Urination DisordersVim
Urologic NeoplasmsPtgs2
uterine cervical neoplasmsPtgs1 , Ptgs2
Ventilator-Induced Lung InjuryPtgs2
Wallerian DegenerationPla2g4a
Weight GainVim
Wernicke EncephalopathyPtgs2
Wilms TumorPtgs2
Pathway Annotations Associated with Genes in the cyclooxygenase mediated pathway of arachidonic acid metabolism
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayPtgs1 , Ptgs2
alpha-linoleic acid metabolic pathwayPla2g4a
antipyrine drug pathwayPtgs1 , Ptgs2
arachidonic acid metabolic pathwayPla2g4a , Ptgs1 , Ptgs2
celecoxib pharmacodynamics pathwayPtgs1 , Ptgs2
celecoxib pharmacokinetics pathwayPtgs1 , Ptgs2
cyclooxygenase mediated pathway of arachidonic acid metabolismAnxa1 , Mknk1 , Pla2g4a , Ptgs1 , Ptgs2 , Vim
diclofenac pharmacodynamics pathwayPtgs1 , Ptgs2
diflunisal pharmacodynamics pathwayPtgs1 , Ptgs2
endothelin signaling pathwayPla2g4a
ether lipid metabolic pathwayPla2g4a
ether lipid metabolic pathwayPla2g4a
etodolac pharmacodynamics pathwayPtgs1 , Ptgs2
etoposide pharmacodynamics pathwayPtgs1 , Ptgs2
etoposide pharmacokinetics pathwayPtgs1 , Ptgs2
Fc epsilon receptor mediated signaling pathwayPla2g4a
Fc gamma receptor mediated signaling pathwayPla2g4a
fenoprofen pharmacodynamics pathwayPtgs1 , Ptgs2
flurbiprofen pharmacodynamics pathwayPtgs1 , Ptgs2
glutamate signaling pathwayPla2g4a
glycerophospholipid metabolic pathwayPla2g4a
gonadotropin-releasing hormone signaling pathwayPla2g4a
ibuprofen pharmacodynamics pathwayPtgs1 , Ptgs2
ibuprofen pharmacokinetics pathwayPtgs1 , Ptgs2
indometacin pharmacodynamics pathwayPtgs1 , Ptgs2
indometacin pharmacodynamics pathwayPtgs1 , Ptgs2
insulin signaling pathwayMknk1
ketoprofen pharmacodynamics pathwayPtgs1 , Ptgs2
ketorolac pharmacodynamics pathwayPtgs1 , Ptgs2
Leishmania infection pathwayPtgs2
leukotriene C4 synthase deficiency pathwayPtgs1 , Ptgs2
linoleic acid metabolic pathwayPla2g4a
long term depressionPla2g4a
lornoxicam pharmacodynamics pathwayPtgs1 , Ptgs2
magnesium salicylate pharmacodynamics pathwayPtgs1 , Ptgs2
mefenamic acid pharmacodynamics pathwayPtgs1 , Ptgs2
meloxicam pharmacodynamics pathwayPtgs1 , Ptgs2
mitogen activated protein kinase signaling pathwayMknk1 , Pla2g4a
nabumetone pharmacodynamics pathwayPtgs1 , Ptgs2
naproxen pharmacodynamics pathwayPtgs1 , Ptgs2
p38 MAPK signaling pathwayMknk1
paracetamol drug pathwayPtgs1 , Ptgs2
piroxicam pharmacodynamics pathwayPtgs1 , Ptgs2
platelet-derived growth factor signaling pathwayPla2g4a
prostanoid biosynthetic pathwayPtgs1 , Ptgs2
salicylic acid pharmacodynamics pathwayPtgs1 , Ptgs2
small cell lung cancer pathwayPtgs2
sodium salicylate pharmacodynamics pathwayPtgs1 , Ptgs2
sphingosine 1-phosphate signaling pathwayPtgs2
sulindac pharmacodynamics pathwayPtgs1 , Ptgs2
tenoxicam pharmacodynamics pathwayPtgs1 , Ptgs2
the extracellular signal-regulated Raf/Mek/Erk signaling pathwayMknk1
tiaprofenic acid pharmacodynamics pathwayPtgs1 , Ptgs2
tolmetin pharmacodynamics pathwayPtgs1 , Ptgs2
Toxoplasma gondii infection pathwayPla2g4a
valdecoxib pharmacodynamics pathwayPtgs1 , Ptgs2
vascular endothelial growth factor signaling pathwayPla2g4a , Ptgs2

References Associated with the cyclooxygenase mediated pathway of arachidonic acid metabolism:

Ontology Path Diagram:

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