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Gene: Cdkn1b (cyclin-dependent kinase inhibitor 1B) Mus musculus
Symbol: Cdkn1b
Name: cyclin-dependent kinase inhibitor 1B
Description: Exhibits cyclin binding activity and cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in several processes, including animal organ development; negative regulation of cell cycle; and regulation of organelle organization. Localizes to cytosol and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart and pericardium; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; breast cancer; multiple endocrine neoplasia type 4; and myelodysplastic syndrome. Orthologous to human CDKN1B (cyclin dependent kinase inhibitor 1B); PARTICIPATES IN forkhead class A signaling pathway; G1/S transition pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5-triiodo-L-thyronine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA408329; AI843786; cyclin-dependent kinase inhibitor p27; Kip1; p27; p27Kip1
Homo sapiens (human) : CDKN1B (cyclin dependent kinase inhibitor 1B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cdkn1b (cyclin-dependent kinase inhibitor 1B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdkn1b (cyclin dependent kinase inhibitor 1B)
Pan paniscus (bonobo/pygmy chimpanzee) : CDKN1B (cyclin dependent kinase inhibitor 1B)
Canis lupus familiaris (dog) : CDKN1B (cyclin dependent kinase inhibitor 1B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdkn1b (cyclin dependent kinase inhibitor 1B)
Sus scrofa (pig) : CDKN1B (cyclin dependent kinase inhibitor 1B)
Chlorocebus sabaeus (African green monkey) : CDKN1B (cyclin dependent kinase inhibitor 1B)
Heterocephalus glaber (naked mole-rat) : Cdkn1b (cyclin dependent kinase inhibitor 1B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl6134,920,401 - 134,925,513 (+)EnsemblGRCm38mm10GRCm38
GRCm386134,920,401 - 134,925,525 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376134,870,419 - 134,875,543 (+)NCBIGRCm37mm9NCBIm37
MGSCv366134,886,110 - 134,889,751 (+)NCBImm8
Celera6137,877,174 - 137,882,301 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map665.77NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cdkn1b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69116
Created: 2001-11-08
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.