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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionEXP 6480464CTDArsenic results in increased expression of PTGS2 proteinPMID:36850985
Ptgs2multiple interactionsEXP 6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of PTGS2 mRNA; nobiletin inhibits the reaction [Arsenic results in increased expression of PTGS2 protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of PTGS2 mRNA]PMID:36822304 PMID:36850985
Ptgs2affects methylationISOPTGS2 (Homo sapiens)6480464CTDArsenic affects the methylation of PTGS2 genePMID:25304211
Ptgs2decreases expressionISOPtgs2 (Mus musculus)6480464CTDArsenic results in decreased expression of PTGS2 mRNAPMID:19654921
Ptgs2decreases methylationISOPTGS2 (Homo sapiens)6480464CTDArsenic results in decreased methylation of PTGS2 promoterPMID:35490796
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDArsenic results in increased expression of PTGS2 mRNAPMID:18039032 PMID:29396848 PMID:31739468
Ptgs2increases expressionISOPtgs2 (Mus musculus)6480464CTDArsenic results in increased expression of PTGS2 proteinPMID:27289040
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTD[Arsenic co-treated with Iron] results in increased expression of PTGS2 mRNA; [Folic Acid co-treated with Arsenic] affects the expression of PTGS2 mRNA; [S-Adenosylmethionine co-treated with Arsenic] affects the expression of PTGS2 mRNA; [S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of PTGS2 promoter]] which results in decreased expression of PTGS2 mRNA; Folic Acid inhibits the reaction [Arsenic results in decreased methylation of PTGS2 promoter]; S-Adenosylmethionine inhibits the reaction [Arsenic results in decreased methylation of PTGS2 promoter]PMID:31739468 PMID:35490796
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