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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:10022
Term: deoxynivalenol
Definition: A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.
Chemical ID: MESH:C007262
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDdeoxynivalenol results in increased expression of PTGS2 mRNA; deoxynivalenol results in increased expression of PTGS2 proteinPMID:20347963 PMID:20633634 PMID:27757495
Ptgs2increases expressionISOPtgs2 (Mus musculus)6480464CTDdeoxynivalenol results in increased expression of PTGS2 mRNA; deoxynivalenol results in increased expression of PTGS2 proteinPMID:11922776 PMID:12377986 PMID:12649040 PMID:14514436 PMID:15570035 PMID:21873375 PMID:24937323 PMID:32416088
Ptgs2increases stabilityISOPtgs2 (Mus musculus)6480464CTDdeoxynivalenol results in increased stability of PTGS2 mRNAPMID:12377986
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTDLutein inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]PMID:20347963
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]; Celecoxib inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]; deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Docosahexaenoic Acids inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 mRNA]; Indomethacin promotes the reaction [deoxynivalenol results in increased expression of PTGS2 protein]; PTGS2 protein affects the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; PTGS2 protein affects the reaction [deoxynivalenol results in increased expression of IL6 protein]; Ro 31-8220 inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [deoxynivalenol results in increased stability of PTGS2 mRNA]PMID:11922776 PMID:12377986 PMID:12649040 PMID:15570035 PMID:32416088
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