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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:17500
Term: 7alpha-hydroxycholesterol
Definition: The 7alpha-hydroxy derivative of cholesterol.
Chemical ID: MESH:C011724
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDcholest-5-en-3 beta,7 alpha-diol results in increased expression of PTGS2 proteinPMID:24802026
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTD[24-hydroxycholesterol co-treated with 27-hydroxycholesterol co-treated with cholest-5-en-3 beta,7 alpha-diol] results in increased expression of PTGS2 proteinPMID:24802026
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