GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ptgs2 | increases activity | EXP | | 6480464 | CTD | arsenite results in increased activity of PTGS2 protein | PMID:34339004 | Ptgs2 | increases expression | EXP | | 6480464 | CTD | arsenite results in increased expression of PTGS2 protein | PMID:20377179 | Ptgs2 | multiple interactions | EXP | | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased expression of PTGS2 protein]; Quercetin inhibits the reaction [arsenite results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [arsenite results in increased activity of PTGS2 protein] | PMID:20377179 PMID:34339004 | Ptgs2 | decreases expression | ISO | PTGS2 (Homo sapiens) | 6480464 | CTD | arsenite results in decreased expression of PTGS2 mRNA | PMID:23974009 PMID:31646340 | Ptgs2 | decreases expression | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | arsenite results in decreased expression of PTGS2 mRNA | PMID:15894712 | Ptgs2 | increases expression | ISO | PTGS2 (Homo sapiens) | 6480464 | CTD | arsenite results in increased expression of PTGS2 mRNA; arsenite results in increased expression of PTGS2 protein | PMID:28444938 PMID:31773452 | Ptgs2 | increases expression | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | arsenite results in increased expression of PTGS2 mRNA; arsenite results in increased expression of PTGS2 protein | PMID:17450217 PMID:19808956 PMID:22463588 PMID:33053406 | Ptgs2 | increases methylation | ISO | PTGS2 (Homo sapiens) | 6480464 | CTD | arsenite results in increased methylation of PTGS2 promoter | PMID:23974009 | Ptgs2 | multiple interactions | ISO | PTGS2 (Homo sapiens) | 6480464 | CTD | arsenite inhibits the reaction [Fulvestrant results in increased expression of PTGS2 mRNA]; EGFR affects the reaction [arsenite results in increased expression of PTGS2 protein]; ERBB2 affects the reaction [arsenite results in increased expression of PTGS2 protein] | PMID:31646340 PMID:31773452 | Ptgs2 | multiple interactions | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole affects the reaction [[CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 protein]; [arsenite co-treated with Benzo(a)pyrene] results in increased expression of PTGS2 mRNA; [CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 mRNA; [CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 protein; [sodium arsenite results in increased abundance of arsenite] affects the reaction [CDKN1B protein affects the expression of PTGS2 mRNA]; [sodium arsenite results in increased abundance of arsenite] which results in increased expression of PTGS2 protein; CDKN1B protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of PTGS2 protein]; CREB1 protein affects the reaction [[CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 mRNA]; CREB1 protein affects the reaction [[CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 protein]; MAP3K8 protein affects the reaction [arsenite results in increased expression of PTGS2 mRNA]; MAP3K8 protein affects the reaction [arsenite results in increased expression of PTGS2 protein]; MAPK11 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of PTGS2 protein]; MAPK12 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [arsenite results in increased expression of PTGS2 protein]; U 0126 inhibits the reaction [arsenite results in increased expression of PTGS2 protein] | PMID:15894712 PMID:19808956 PMID:23639288 | | ||||||||||||||||||||||
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