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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:38912
Term: Ro 31-8220
Definition: An imidothiocarbamic ester that has formula C25H23N5O2S.
Chemical ID: MESH:C064758
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2multiple interactionsISORGD:7310066480464CTDRo 31-8220 inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein], Ro 31-8220 inhibits the reaction [NCX 4040 results in increased expression of PTGS2 protein]

PMID:11854442, PMID:19576865
Ptgs2multiple interactionsISORGD:7310076480464CTDRo 31-8220 inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]

PMID:32416088
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.