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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:37550
Term: sphingosine 1-phosphate
Definition: A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
Chemical ID: MESH:C060506
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases expressionISORGD:7310066480464CTDsphingosine 1-phosphate results in increased expression of PTGS2 mRNA sphingosine 1-phosphate results in increased expression of PTGS2 protein

PMID:18612546 PMID:26518876
Ptgs2multiple interactionsISORGD:7310066480464CTDdihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein] JTE 013 inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]] JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein] JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]] Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]] MK 2206 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein] S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA] sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein] sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein] Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]] Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]

PMID:18612546 PMID:26518876
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