PTGS2 (prostaglandin-endoperoxide synthase 2) - Rat Genome Database

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Gene: PTGS2 (prostaglandin-endoperoxide synthase 2) Canis lupus familiaris
Analyze
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
RGD ID: 12279597
Description: ENCODES a protein that exhibits oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (ortholog); INVOLVED IN cellular response to non-ionic osmotic stress; negative regulation of apoptotic process; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); acute kidney failure (ortholog); Acute Liver Failure (ortholog); FOUND IN cytoplasm; caveola (ortholog); nucleus (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; carprofen; etodolac
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: COX-2; cyclooxygenase 2; cyclooxygenase type 2; prostaglandin G/H synthase 2; prostaglandin G/H synthase-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1719,668,079 - 19,674,903 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl719,668,082 - 19,674,903 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha719,190,741 - 19,197,565 (-)NCBI
ROS_Cfam_1.0719,405,501 - 19,412,325 (-)NCBI
ROS_Cfam_1.0 Ensembl719,405,504 - 19,412,176 (-)Ensembl
UMICH_Zoey_3.1719,311,510 - 19,318,356 (-)NCBI
UNSW_CanFamBas_1.0719,420,827 - 19,427,651 (-)NCBI
UU_Cfam_GSD_1.0719,552,954 - 19,559,778 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (ISO)
Adrenal Gland Neoplasms  (ISO)
Albuminuria  (ISO)
Alcohol Withdrawal Delirium  (ISO)
allergic rhinitis  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Anaphylaxis  (ISO)
Anorexia  (ISO)
arteriosclerosis  (ISO)
asphyxia neonatorum  (ISO)
aspirin-induced respiratory disease  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
avian influenza  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
B-cell lymphoma  (ISO)
Barrett's esophagus  (ISO)
bipolar disorder  (ISO)
bladder neck obstruction  (ISO)
Bone Fractures  (ISO)
Bone Neoplasms  (ISO)
Brain Injuries  (ISO)
Brain Injuries, Traumatic  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cachexia  (ISO)
calcification of aortic valve  (ISO)
carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
cardiomyopathy  (ISO)
cardiovascular system disease  (ISO)
Cerebral Hemorrhage  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholangiocarcinoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
cognitive disorder  (ISO)
colitis  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Cough  (ISO)
COVID-19  (ISO)
Creutzfeldt-Jakob disease  (ISO)
Crohn's disease  (ISO)
cryptorchidism  (ISO)
cystic fibrosis  (ISO)
cystitis  (ISO)
demyelinating disease  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
disease of cellular proliferation  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
ductal carcinoma in situ  (ISO)
duodenal ulcer  (ISO)
Edema  (ISO)
end stage renal disease  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
esophagitis  (ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
familial adenomatous polyposis  (ISO)
fatty liver disease  (ISO)
Fetal Growth Retardation  (ISO)
Fever  (ISO)
Fibrosis  (ISO)
Gallbladder Neoplasms  (ISO)
gastric ulcer  (ISO)
gastritis  (ISO)
gastroesophageal reflux disease  (ISO)
gastrointestinal stromal tumor  (ISO)
glioblastoma  (ISO)
gliosarcoma  (ISO)
granulosa cell tumor  (ISO)
Graves ophthalmopathy  (ISO)
growth hormone secreting pituitary adenoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
hydronephrosis  (ISO)
Hyperalgesia  (ISO)
Hyperemia  (ISO)
hyperglycemia  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Hypoxia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
in situ carcinoma  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intestinal obstruction  (ISO)
Intestinal Polyps  (ISO)
invasive ductal carcinoma  (ISO)
kidney disease  (ISO)
Kidney Neoplasms  (ISO)
Laryngeal Neoplasms  (ISO)
Laryngeal Papillomatosis  (ISO)
Left Ventricular Hypertrophy  (ISO)
leiomyosarcoma  (ISO)
liver cirrhosis  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
mental depression  (ISO)
Metabolic Syndrome  (ISO)
mouth disease  (ISO)
Mouth Neoplasms  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
nephroblastoma  (ISO)
nephrotic syndrome  (ISO)
nervous system disease  (ISO)
Neurogenic Inflammation  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
occupational asthma  (ISO)
open-angle glaucoma  (ISO)
oral mucosa leukoplakia  (ISO)
oral submucous fibrosis  (ISO)
osteoarthritis  (ISO)
Ovarian Neoplasms  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (ISO)
papilloma  (ISO)
parathyroid carcinoma  (ISO)
Parkinsonism  (ISO)
pericardial effusion  (ISO)
Peripheral Nerve Injuries  (ISO)
pleurisy  (ISO)
polycystic kidney disease  (ISO)
portal hypertension  (ISO)
pre-malignant neoplasm  (ISO)
Precocious Puberty  (ISO)
Premature Birth  (ISO)
prolactinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
prostatitis  (ISO)
proteinuria  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
Radiation Injuries, Experimental  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
retrograde amnesia  (ISO)
rheumatoid arthritis  (ISO)
sarcoidosis  (ISO)
schizophrenia  (ISO)
secondary hyperparathyroidism  (ISO)
skin disease  (ISO)
Skin Neoplasms  (ISO)
Sleep Deprivation  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
thrombosis  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
Uterine Cervical Neoplasms  (ISO)
Ventilator-Induced Lung Injury  (ISO)
visual epilepsy  (ISO)
Wernicke encephalopathy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
angiogenesis  (ISO)
bone mineralization  (ISO)
brown fat cell differentiation  (IEA)
cellular oxidant detoxification  (IEA)
cellular response to ATP  (ISO)
cellular response to fluid shear stress  (IEA,ISO)
cellular response to heat  (ISO)
cellular response to hypoxia  (IEA)
cellular response to lead ion  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to non-ionic osmotic stress  (IDA,IEA)
cellular response to UV  (ISO)
cyclooxygenase pathway  (IBA,IEA,ISO)
decidualization  (IEA,ISO)
embryo implantation  (IEA,ISO)
fatty acid biosynthetic process  (IEA)
fatty acid metabolic process  (IEA)
hair cycle  (ISO)
inflammatory response  (IEA,ISO)
learning  (ISO)
lipid metabolic process  (IEA)
maintenance of blood-brain barrier  (ISO)
memory  (ISO)
negative regulation of apoptotic process  (IDA,IEA)
negative regulation of calcium ion transport  (ISO)
negative regulation of cell cycle  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  (IEA,IMP)
negative regulation of smooth muscle contraction  (ISO)
negative regulation of synaptic transmission, dopaminergic  (ISO)
organic substance metabolic process  (IEA)
ovulation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of brown fat cell differentiation  (IEA)
positive regulation of cell death  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of fever generation  (IEA)
positive regulation of fibroblast growth factor production  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IDA,IEA)
positive regulation of platelet-derived growth factor production  (ISO)
positive regulation of prostaglandin biosynthetic process  (IDA,IEA)
positive regulation of protein import into nucleus  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of smooth muscle contraction  (ISO)
positive regulation of synaptic plasticity  (ISO)
positive regulation of synaptic transmission, glutamatergic  (ISO)
positive regulation of transforming growth factor beta production  (ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
positive regulation of vasoconstriction  (ISO)
prostaglandin biosynthetic process  (IEA,ISO)
prostaglandin metabolic process  (IEA)
prostaglandin secretion  (IEA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of neuroinflammatory response  (IEA)
response to angiotensin  (ISO)
response to cytokine  (ISO)
response to estradiol  (ISO)
response to fatty acid  (ISO)
response to fructose  (ISO)
response to glucocorticoid  (ISO)
response to lipopolysaccharide  (ISO)
response to lithium ion  (ISO)
response to manganese ion  (ISO)
response to nematode  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to oxidative stress  (IEA)
response to radiation  (ISO)
response to tumor necrosis factor  (ISO)
response to vitamin D  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of pain  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
celecoxib pharmacokinetics pathway  (ISO)
cyclooxygenase mediated pathway of arachidonic acid metabolism  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
etoposide pharmacodynamics pathway  (ISO)
etoposide pharmacokinetics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacokinetics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway  (ISO)
paracetamol drug pathway  (ISO)
piroxicam pharmacodynamics pathway  (ISO)
pro-inflammatory cytokine mediated pathway  (ISO)
prostanoid biosynthetic pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sphingosine 1-phosphate signaling pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:11861541   PMID:16538539   PMID:16966442   PMID:17316722   PMID:17708399   PMID:17921331   PMID:18562222   PMID:18717642   PMID:19005164   PMID:19243816   PMID:19274754   PMID:19535119  
PMID:19605908   PMID:19691646   PMID:19795944   PMID:20207364   PMID:22731506   PMID:23489848   PMID:23531445   PMID:24060154   PMID:24197070   PMID:24813155   PMID:26549149   PMID:27892876  
PMID:28956485   PMID:29867151  


Genomics

Comparative Map Data
PTGS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1719,668,079 - 19,674,903 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl719,668,082 - 19,674,903 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha719,190,741 - 19,197,565 (-)NCBI
ROS_Cfam_1.0719,405,501 - 19,412,325 (-)NCBI
ROS_Cfam_1.0 Ensembl719,405,504 - 19,412,176 (-)Ensembl
UMICH_Zoey_3.1719,311,510 - 19,318,356 (-)NCBI
UNSW_CanFamBas_1.0719,420,827 - 19,427,651 (-)NCBI
UU_Cfam_GSD_1.0719,552,954 - 19,559,778 (-)NCBI
PTGS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,671,791 - 186,680,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1186,671,791 - 186,680,922 (-)EnsemblGRCh38hg38GRCh38
GRCh371186,640,923 - 186,649,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361184,907,592 - 184,916,179 (-)NCBINCBI36hg18NCBI36
Build 341183,372,625 - 183,381,213NCBI
Celera1159,751,694 - 159,760,309 (-)NCBI
Cytogenetic Map1q31.1NCBI
HuRef1157,875,712 - 157,884,327 (-)NCBIHuRef
CHM1_11188,062,673 - 188,071,288 (-)NCBICHM1_1
T2T-CHM13v2.01186,026,616 - 186,035,248 (-)NCBI
Ptgs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,975,782 - 149,983,985 (+)NCBIGRCm39mm39
GRCm39 Ensembl1149,975,782 - 149,983,978 (+)Ensembl
GRCm381150,100,031 - 150,108,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,100,031 - 150,108,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv371151,947,254 - 151,955,147 (+)NCBIGRCm37mm9NCBIm37
MGSCv361151,862,342 - 151,870,235 (+)NCBImm8
Celera1152,546,728 - 152,554,611 (+)NCBICelera
Cytogenetic Map1G1NCBI
cM Map163.84NCBI
Ptgs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21362,164,080 - 62,169,770 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1362,163,932 - 62,172,188 (+)Ensembl
Rnor_6.01367,351,230 - 67,356,920 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,351,087 - 67,359,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,315,959 - 72,324,483 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,427,288 - 64,432,978 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11364,441,245 - 64,449,480 (+)NCBI
Celera1362,129,439 - 62,135,131 (+)NCBICelera
Cytogenetic Map13q21NCBI
Ptgs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540625,079,945 - 25,086,171 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540625,077,988 - 25,086,259 (-)NCBIChiLan1.0ChiLan1.0
PTGS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11166,355,845 - 166,364,517 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,355,845 - 166,364,519 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01162,205,534 - 162,214,130 (-)NCBIMhudiblu_PPA_v0panPan3
Ptgs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934485,975,505 - 85,982,237 (+)NCBI
SpeTri2.0NW_0049364813,821,564 - 3,828,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9127,850,015 - 127,858,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19127,850,164 - 127,858,866 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29140,251,667 - 140,260,362 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12542,733,535 - 42,742,463 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2542,734,771 - 42,742,429 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605543,903,786 - 43,913,892 (+)NCBIVero_WHO_p1.0
Ptgs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248146,897,857 - 6,903,728 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248146,897,818 - 6,904,890 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2
Low 5 2 16 6 4 6 5 2 6 4
Below cutoff 3 6 2 1 6 10 8 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000021841   ⟹   ENSCAFP00000020288
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl719,668,082 - 19,674,903 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845009561   ⟹   ENSCAFP00845007477
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl719,405,504 - 19,412,176 (-)Ensembl
RefSeq Acc Id: NM_001003354   ⟹   NP_001003354
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1719,668,079 - 19,674,903 (-)NCBI
Dog10K_Boxer_Tasha719,190,741 - 19,197,565 (-)NCBI
ROS_Cfam_1.0719,405,501 - 19,412,325 (-)NCBI
UMICH_Zoey_3.1719,311,510 - 19,318,356 (-)NCBI
UNSW_CanFamBas_1.0719,420,827 - 19,427,651 (-)NCBI
UU_Cfam_GSD_1.0719,552,954 - 19,559,778 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038670503   ⟹   XP_038526431
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0719,405,501 - 19,412,186 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001003354 (Get FASTA)   NCBI Sequence Viewer  
  XP_038526431 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK31626 (Get FASTA)   NCBI Sequence Viewer  
  AAK97783 (Get FASTA)   NCBI Sequence Viewer  
  ADO27661 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003354   ⟸   NM_001003354
- Peptide Label: precursor
- UniProtKB: Q8SPQ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000020288   ⟸   ENSCAFT00000021841
RefSeq Acc Id: XP_038526431   ⟸   XM_038670503
- Peptide Label: isoform X1
RefSeq Acc Id: ENSCAFP00845007477   ⟸   ENSCAFT00845009561
Protein Domains
EGF-like

Promoters
RGD ID:13683927
Promoter ID:EPDNEW_C1995
Type:single initiation site
Name:PTGS2_1
Description:prostaglandin-endoperoxide synthase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1719,674,931 - 19,674,991EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
7 19669818 19669819 A T snv Saluki (SL006)
7 19672955 19672956 G A snv Chinese indigenous dogs (YJ9), Chinese indigenous dogs (YJ6)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000013762 Ensembl
  ENSCAFG00030000542 UniProtKB/TrEMBL
  ENSCAFG00040005256 UniProtKB/TrEMBL
  ENSCAFG00845005378 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030000768.1 UniProtKB/TrEMBL
  ENSCAFP00040008538 UniProtKB/TrEMBL
  ENSCAFP00845007477 ENTREZGENE
  ENSCAFP00845007477.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030000891.1 UniProtKB/TrEMBL
  ENSCAFT00040009852 UniProtKB/TrEMBL
  ENSCAFT00845009561 ENTREZGENE
  ENSCAFT00845009561.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/TrEMBL
InterPro COX-2 UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  Haem_peroxidase_animal UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/TrEMBL
KEGG Report cfa:442942 UniProtKB/TrEMBL
NCBI Gene PTGS2 ENTREZGENE
PANTHER PTHR11903:SF8 UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
PRINTS ANPEROXIDASE UniProtKB/TrEMBL
PROSITE EGF_3 UniProtKB/TrEMBL
  PEROXIDASE_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF48113 UniProtKB/TrEMBL
UniProt A0A8C0LV05_CANLF UniProtKB/TrEMBL
  A0A8C0QK63_CANLF UniProtKB/TrEMBL
  Q8SPQ9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45152 ENTREZGENE