GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ptgs2 | increases expression | ISO | PTGS2 (Homo sapiens) | 6480464 | CTD | nickel sulfate results in increased expression of PTGS2 mRNA | PMID:16780908 | Ptgs2 | increases expression | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | nickel sulfate results in increased expression of PTGS2 protein | PMID:26607348 | Ptgs2 | multiple interactions | ISO | PTGS2 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of PTGS2 protein]; [nickel sulfate co-treated with Dinoprostone] results in increased expression of PTGS2 protein; [nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of PTGS2 protein; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of PTGS2 mRNA]; HIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of PTGS2 protein]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of PTGS2 mRNA]; PTGS2 mRNA affects the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of CXCL1 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of CXCL5 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of CXCL8 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of VEGFA protein]; SB 203580 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of PTGS2 protein]; U 0126 inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of PTGS2 protein] | PMID:18096868 PMID:18832182 PMID:20600219 | Ptgs2 | multiple interactions | ISO | Ptgs2 (Mus musculus) | 6480464 | CTD | puerarin inhibits the reaction [nickel sulfate results in increased expression of PTGS2 protein] | PMID:26607348 | | ||||||||||||||||||||||
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