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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70499
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Birc5
Name: baculoviral IAP repeat-containing 5
Acc ID: CHEBI:10136
Term: gingerol
Definition: A beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger.
Chemical ID: MESH:C007845
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Birc5decreases expressionISOBIRC5 (Homo sapiens)6480464CTDgingerol results in decreased expression of BIRC5 proteinPMID:18030663 PMID:25034532
Birc5multiple interactionsISOBirc5 (Mus musculus)6480464CTDgingerol inhibits the reaction [Testosterone results in increased expression of BIRC5 protein]PMID:18030663
Birc5multiple interactionsISOBIRC5 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [gingerol results in decreased expression of BIRC5 protein]; gingerol inhibits the reaction [Testosterone results in increased expression of BIRC5 protein]PMID:18030663 PMID:25034532
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