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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70499
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Birc5
Name: baculoviral IAP repeat-containing 5
Acc ID: CHEBI:77012
Term: methylseleninic acid
Definition: An organoselenium compound that is seleninic acid in which the hydrogen attached to selenium is replaced by a methyl group.
Chemical ID: MESH:C008493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Birc5decreases expressionISOBIRC5 (Homo sapiens)6480464CTDmethylselenic acid results in decreased expression of BIRC5 mRNA; methylselenic acid results in decreased expression of BIRC5 proteinPMID:12517777 PMID:17876054 PMID:18444175 PMID:18567002
Birc5multiple interactionsISOBIRC5 (Homo sapiens)6480464CTD[2,5,7,8-tetramethyl-2R-(4R,8R,12-trimethyltridecyl)chroman-6-yloxy acetic acid co-treated with methylselenic acid co-treated with resveratrol] results in decreased expression of BIRC5 protein; methylselenic acid inhibits the reaction [SP1 protein binds to BIRC5 promoter]PMID:17876054 PMID:18444175
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