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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70499
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Birc5
Name: baculoviral IAP repeat-containing 5
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Birc5decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of BIRC5 mRNAPMID:25181051
Birc5increases expressionEXP 6480464CTDbisphenol A results in increased expression of BIRC5 mRNAPMID:18180321 PMID:32145629
Birc5affects expressionISOBIRC5 (Homo sapiens)6480464CTDbisphenol A affects the expression of BIRC5 mRNAPMID:21826169 PMID:30903817
Birc5decreases expressionISOBIRC5 (Homo sapiens)6480464CTDbisphenol A analog results in decreased expression of BIRC5 mRNA; bisphenol A results in decreased expression of BIRC5 mRNAPMID:27979917 PMID:29275510 PMID:32387340 PMID:33670352 PMID:36982678
Birc5increases expressionISOBirc5 (Mus musculus)6480464CTDbisphenol A results in increased expression of BIRC5 mRNAPMID:27623287
Birc5increases expressionISOBIRC5 (Homo sapiens)6480464CTDbisphenol A results in increased expression of BIRC5 mRNA; bisphenol A results in increased expression of BIRC5 proteinPMID:16474171 PMID:19270784 PMID:33312107
Birc5multiple interactionsISOBIRC5 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of BIRC5 mRNA; [naringenin co-treated with bisphenol A] results in increased expression of BIRC5 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BIRC5 mRNAPMID:28628672 PMID:36235125
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