Acly (ATP citrate lyase) - Rat Genome Database

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Gene: Acly (ATP citrate lyase) Rattus norvegicus
Analyze
Symbol: Acly
Name: ATP citrate lyase
RGD ID: 2018
Description: Enables ATP citrate synthase activity. Involved in acetyl-CoA metabolic process; citrate metabolic process; and fatty acid biosynthetic process. Predicted to be located in ciliary basal body and nucleoplasm. Predicted to be active in cytosol. Orthologous to human ACLY (ATP citrate lyase); PARTICIPATES IN fatty acid biosynthetic pathway; citric acid cycle pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ACL; ATP-citrate (pro-S-)-lyase; ATP-citrate synthase; citrate cleavage enzyme; Clatp; MGC124629
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81085,912,402 - 85,964,605 (-)NCBIGRCr8
mRatBN7.21085,412,045 - 85,464,253 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,412,049 - 85,463,320 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,448,266 - 90,499,722 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01089,927,528 - 89,978,548 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,320,315 - 85,371,541 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,392,248 - 88,442,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,392,248 - 88,442,845 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,185,495 - 88,237,133 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,420,934 - 89,471,398 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,435,312 - 89,485,719 (-)NCBI
Celera1084,129,399 - 84,179,946 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-beta-thujone  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-camphor  (ISO)
(R)-linalyl acetate  (ISO)
1,2-dimethylhydrazine  (ISO)
1,8-cineole  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dimethoxyphenol  (ISO)
2-chloroethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetyl-CoA  (ISO)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldrin  (ISO)
alpha-linolenic acid  (EXP)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
benzene  (EXP)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
benzylpenicillin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
brexpiprazole  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP)
caffeine  (EXP,ISO)
calyculin a  (ISO)
camphor  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
chloroethene  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cis-caffeic acid  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corn oil  (EXP)
corticosterone  (EXP)
cortisol  (ISO)
coumarin  (EXP)
coumestrol  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
cyproconazole  (EXP)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
dexamethasone  (EXP)
Di-n-octyl phthalate  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP,ISO)
erythromycin A  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
ferrostatin-1  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP)
furan  (EXP)
furfural  (ISO)
gamma-hexachlorocyclohexane  (EXP)
Ganoderic acid A  (ISO)
genistein  (ISO)
glucose  (EXP,ISO)
glyphosate  (ISO)
guggulsterone  (ISO)
GW 3965  (ISO)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
Honokiol  (EXP)
hydrogen cyanide  (ISO)
indometacin  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
josamycin  (ISO)
L-methionine  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
linoleic acid  (EXP)
metformin  (EXP,ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
monosodium L-glutamate  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-methyl-N-nitrosourea  (EXP)
n-propyl gallate  (EXP)
naloxone  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP)
nimesulide  (EXP)
Oleacein  (ISO)
oleic acid  (ISO)
orotic acid  (EXP)
Osajin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
Pomiferin  (ISO)
potassium cyanide  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procymidone  (ISO)
propamocarb  (ISO)
propiconazole  (EXP)
Propiverine  (EXP)
puerarin  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
Rosavin  (ISO)
rotenone  (EXP,ISO)
rutin  (ISO)
sabinene  (ISO)
sarin  (ISO)
SB 431542  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
spathulenol  (ISO)
sucrose  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
toosendanin  (ISO)
trametinib  (ISO)
trans-caffeic acid  (ISO)
Tributyltin oxide  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vemurafenib  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
ciliary basal body  (IEA,ISO)
cytoplasm  (IEA)
cytosol  (IBA,IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes. Berwick DC, etal., J Biol Chem. 2002 Sep 13;277(37):33895-900. Epub 2002 Jul 09.
2. [Biological-molecular trend in psychiatry] Bilikiewicz A Pol Tyg Lek 1978 Jun 26;33(26):1046-50.
3. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
4. [Sanitary and hygienic evaluation of a technological line for removing manure]. Dolgov VS, Veterinariia. 1978 Dec;(12):61-3.
5. Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age. Elshourbagy NA, etal., J Biol Chem 1990 Jan 25;265(3):1430-5.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats. Huong DT and Ide T, Br J Nutr. 2008 Jul;100(1):79-87. Epub 2007 Dec 7.
9. Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in pancreatic beta-cells. Kamath V, etal., Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E276-86. doi: 10.1152/ajpendo.00091.2010. Epub 2010 May 25.
10. Variant cDNA sequences of human ATP:citrate lyase: cloning, expression, and purification from baculovirus-infected insect cells. Lord KA, etal., Protein Expr Purif. 1997 Feb;9(1):133-41. doi: 10.1006/prep.1996.0668.
11. Activity of adenosine deaminase in the sleep regulatory areas of the rat CNS. Mackiewicz M, etal., Brain Res Mol Brain Res 2000 Sep 15;80(2):252-5.
12. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Menendez JA and Lupu R, Nat Rev Cancer. 2007 Oct;7(10):763-77.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Effect of cold acclimation on brown adipose tissue fatty acid synthesis in rats adapted to a high-protein, carbohydrate-free diet. Moura MA, etal., Metabolism. 2001 Dec;50(12):1493-8.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1371749   PMID:2176822   PMID:8688462   PMID:10653665   PMID:11989980   PMID:12086928   PMID:12477932   PMID:16396499   PMID:16854843   PMID:17823126   PMID:18614015   PMID:19056867  
PMID:19286649   PMID:19946888   PMID:20458337   PMID:20460097   PMID:21454710   PMID:23225248   PMID:23533145   PMID:23932781   PMID:24625528   PMID:25450640   PMID:26296893   PMID:32357304  
PMID:33450132  


Genomics

Comparative Map Data
Acly
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81085,912,402 - 85,964,605 (-)NCBIGRCr8
mRatBN7.21085,412,045 - 85,464,253 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,412,049 - 85,463,320 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,448,266 - 90,499,722 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01089,927,528 - 89,978,548 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,320,315 - 85,371,541 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,392,248 - 88,442,845 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,392,248 - 88,442,845 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,185,495 - 88,237,133 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,420,934 - 89,471,398 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,435,312 - 89,485,719 (-)NCBI
Celera1084,129,399 - 84,179,946 (-)NCBICelera
Cytogenetic Map10q31NCBI
ACLY
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,866,917 - 41,930,545 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1741,866,917 - 41,930,542 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,023,170 - 40,075,275 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,276,705 - 37,328,798 (-)NCBINCBI36Build 36hg18NCBI36
Build 341737,276,706 - 37,328,798NCBI
Celera1736,674,340 - 36,725,809 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,785,140 - 35,836,956 (-)NCBIHuRef
CHM1_11740,258,594 - 40,311,000 (-)NCBICHM1_1
T2T-CHM13v2.01742,723,421 - 42,775,531 (-)NCBIT2T-CHM13v2.0
Acly
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,367,178 - 100,418,826 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,367,179 - 100,418,826 (-)EnsemblGRCm39 Ensembl
GRCm3811100,476,352 - 100,528,000 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,476,353 - 100,528,000 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,337,670 - 100,389,215 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,292,446 - 100,343,991 (-)NCBIMGSCv36mm8
Celera11111,095,710 - 111,147,350 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.47NCBI
Acly
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,058,727 - 16,092,589 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,058,916 - 16,091,831 (-)NCBIChiLan1.0ChiLan1.0
ACLY
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21923,053,400 - 23,115,308 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,943,541 - 25,005,482 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,385,335 - 15,447,269 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,615,957 - 15,665,692 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,615,994 - 15,664,800 (+)Ensemblpanpan1.1panPan2
ACLY
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,929,530 - 20,974,200 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,929,614 - 20,973,663 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,390,153 - 20,434,737 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,648,350 - 21,693,226 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,648,295 - 21,693,224 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,433,791 - 20,478,844 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,700,516 - 20,745,189 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,803,776 - 20,849,064 (+)NCBIUU_Cfam_GSD_1.0
Acly
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,276,950 - 20,317,138 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,757,985 - 16,798,237 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649016,758,001 - 16,798,152 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACLY
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,796,749 - 20,841,298 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,796,678 - 20,841,301 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,082,937 - 21,106,727 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACLY
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,343,175 - 64,392,011 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607735,156,831 - 35,219,899 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acly
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,872,454 - 1,911,004 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,872,413 - 1,910,495 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acly
401 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:452
Count of miRNA genes:197
Interacting mature miRNAs:227
Transcripts:ENSRNOT00000023447, ENSRNOT00000043172
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
D10Wox19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,412,685 - 85,412,915 (+)MAPPERmRatBN7.2
Rnor_6.01088,392,889 - 88,393,118NCBIRnor6.0
Rnor_5.01088,186,136 - 88,186,365UniSTSRnor5.0
RGSC_v3.41089,421,575 - 89,421,804RGDRGSC3.4
RGSC_v3.41089,421,575 - 89,421,804UniSTSRGSC3.4
RGSC_v3.11089,435,945 - 89,436,174RGD
Celera1084,130,040 - 84,130,269UniSTS
RH 3.4 Map10857.8UniSTS
RH 3.4 Map10857.8RGD
RH 2.0 Map10966.3RGD
Cytogenetic Map10q32.1UniSTS
D10Arb16   No map positions available.
D10Mco75  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81085,930,592 - 85,930,855 (+)Marker Load Pipeline
mRatBN7.21085,430,237 - 85,430,500 (+)MAPPERmRatBN7.2
Rnor_6.01088,410,439 - 88,410,701NCBIRnor6.0
Rnor_5.01088,203,686 - 88,203,948UniSTSRnor5.0
RGSC_v3.41089,439,125 - 89,439,388RGDRGSC3.4
RGSC_v3.41089,439,126 - 89,439,388UniSTSRGSC3.4
RGSC_v3.11089,453,495 - 89,453,758RGD
Celera1084,147,582 - 84,147,844UniSTS
Cytogenetic Map10q32.1UniSTS
D10Wox48  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,430,237 - 85,430,498 (+)MAPPERmRatBN7.2
Rnor_6.01088,410,439 - 88,410,699NCBIRnor6.0
Rnor_5.01088,203,686 - 88,203,946UniSTSRnor5.0
RGSC_v3.41089,439,126 - 89,439,386UniSTSRGSC3.4
Celera1084,147,582 - 84,147,842UniSTS
Cytogenetic Map10q32.1UniSTS
AW526881  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,412,474 - 85,412,567 (+)MAPPERmRatBN7.2
Rnor_6.01088,392,678 - 88,392,770NCBIRnor6.0
Rnor_5.01088,185,925 - 88,186,017UniSTSRnor5.0
RGSC_v3.41089,421,364 - 89,421,456UniSTSRGSC3.4
Celera1084,129,829 - 84,129,921UniSTS
RH 3.4 Map10858.6UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000023447   ⟹   ENSRNOP00000023447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,412,049 - 85,463,310 (-)Ensembl
Rnor_6.0 Ensembl1088,392,248 - 88,442,845 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000043172   ⟹   ENSRNOP00000046597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,412,049 - 85,463,320 (-)Ensembl
Rnor_6.0 Ensembl1088,392,248 - 88,442,845 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077579   ⟹   ENSRNOP00000073397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,412,049 - 85,463,298 (-)Ensembl
Rnor_6.0 Ensembl1088,392,257 - 88,442,796 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114571   ⟹   ENSRNOP00000093648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,412,049 - 85,463,310 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119580   ⟹   ENSRNOP00000084652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,435,410 - 85,463,310 (-)Ensembl
RefSeq Acc Id: NM_001111095   ⟹   NP_001104565
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81085,912,402 - 85,963,631 (-)NCBI
mRatBN7.21085,412,045 - 85,463,279 (-)NCBI
Rnor_6.01088,392,248 - 88,442,845 (-)NCBI
Rnor_5.01088,185,495 - 88,237,133 (-)NCBI
RGSC_v3.41089,420,934 - 89,471,398 (-)RGD
Celera1084,129,399 - 84,179,946 (-)RGD
Sequence:
RefSeq Acc Id: NM_016987   ⟹   NP_058683
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81085,912,402 - 85,963,631 (-)NCBI
mRatBN7.21085,412,045 - 85,463,279 (-)NCBI
Rnor_6.01088,392,248 - 88,442,845 (-)NCBI
Rnor_5.01088,185,495 - 88,237,133 (-)NCBI
RGSC_v3.41089,420,934 - 89,471,398 (-)RGD
Celera1084,129,399 - 84,179,946 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085164   ⟹   XP_038941092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81085,912,406 - 85,964,605 (-)NCBI
mRatBN7.21085,412,053 - 85,464,253 (-)NCBI
RefSeq Acc Id: NP_058683   ⟸   NM_016987
- Peptide Label: isoform 1
- UniProtKB: Q8VIQ1 (UniProtKB/Swiss-Prot),   Q497C7 (UniProtKB/Swiss-Prot),   P16638 (UniProtKB/Swiss-Prot),   G3V888 (UniProtKB/TrEMBL),   A6HJ39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001104565   ⟸   NM_001111095
- Peptide Label: isoform 2
- UniProtKB: Q8VIQ1 (UniProtKB/Swiss-Prot),   Q497C7 (UniProtKB/Swiss-Prot),   P16638 (UniProtKB/Swiss-Prot),   G3V9G4 (UniProtKB/TrEMBL),   A6HJ38 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046597   ⟸   ENSRNOT00000043172
Ensembl Acc Id: ENSRNOP00000023447   ⟸   ENSRNOT00000023447
Ensembl Acc Id: ENSRNOP00000073397   ⟸   ENSRNOT00000077579
RefSeq Acc Id: XP_038941092   ⟸   XM_039085164
- Peptide Label: isoform X1
- UniProtKB: Q8VIQ1 (UniProtKB/Swiss-Prot),   Q497C7 (UniProtKB/Swiss-Prot),   P16638 (UniProtKB/Swiss-Prot),   G3V888 (UniProtKB/TrEMBL),   A6HJ39 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084652   ⟸   ENSRNOT00000119580
Ensembl Acc Id: ENSRNOP00000093648   ⟸   ENSRNOT00000114571
Protein Domains
ATP-citrate synthase citrate-binding   ATP-grasp   CoA-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16638-F1-model_v2 AlphaFold P16638 1-1100 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697727
Promoter ID:EPDNEW_R8248
Type:multiple initiation site
Name:Acly_1
Description:ATP citrate lyase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01088,442,822 - 88,442,882EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2018 AgrOrtholog
BioCyc Gene G2FUF-23232 BioCyc
BioCyc Pathway PWY-5172 [acetyl-CoA biosynthesis from citrate] BioCyc
BioCyc Pathway Image PWY-5172 BioCyc
Ensembl Genes ENSRNOG00000016924 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000023447 ENTREZGENE
  ENSRNOT00000043172 ENTREZGENE
Gene3D-CATH 1.10.230.10 UniProtKB/Swiss-Prot
  1.10.580.10 UniProtKB/Swiss-Prot
  3.30.470.110 UniProtKB/Swiss-Prot
  3.40.50.261 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7934668 IMAGE-MGC_LOAD
InterPro ATP-citrate_synthase UniProtKB/Swiss-Prot
  Cit_synth/succinyl-CoA_lig_AS UniProtKB/Swiss-Prot
  Citrate-bd UniProtKB/Swiss-Prot
  Citrate_synth-like_lrg_a-sub UniProtKB/Swiss-Prot
  Citrate_synth-like_sm_a-sub UniProtKB/Swiss-Prot
  Citrate_synthase UniProtKB/Swiss-Prot
  Citrate_synthase_sf UniProtKB/Swiss-Prot
  Citrt_syn/SCS-alpha_CS UniProtKB/Swiss-Prot
  CoA-bd UniProtKB/Swiss-Prot
  CoA_ligase UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
  Succ-CoA_synthase_bsu_CS UniProtKB/Swiss-Prot
  Succinyl-CoA_synth-like UniProtKB/Swiss-Prot
KEGG Report rno:24159 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124629 IMAGE-MGC_LOAD
NCBI Gene 24159 ENTREZGENE
PANTHER ATP-CITRATE SYNTHASE UniProtKB/Swiss-Prot
  ATP-CITRATE SYNTHASE UniProtKB/Swiss-Prot
Pfam Citrate_bind UniProtKB/Swiss-Prot
  Citrate_synt UniProtKB/Swiss-Prot
  CoA_binding UniProtKB/Swiss-Prot
  Ligase_CoA UniProtKB/Swiss-Prot
PhenoGen Acly PhenoGen
PIRSF ATP_citrt_syn UniProtKB/Swiss-Prot
PROSITE SUCCINYL_COA_LIG_1 UniProtKB/Swiss-Prot
  SUCCINYL_COA_LIG_2 UniProtKB/Swiss-Prot
  SUCCINYL_COA_LIG_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016924 RatGTEx
SMART CoA_binding UniProtKB/Swiss-Prot
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot
  SSF48256 UniProtKB/Swiss-Prot
  SSF51735 UniProtKB/Swiss-Prot
  SSF52210 UniProtKB/Swiss-Prot
UniProt A0A0G2K5E7_RAT UniProtKB/TrEMBL
  A0A8I6AM81_RAT UniProtKB/TrEMBL
  A0A8I6GAT1_RAT UniProtKB/TrEMBL
  A6HJ37_RAT UniProtKB/TrEMBL
  A6HJ38 ENTREZGENE, UniProtKB/TrEMBL
  A6HJ39 ENTREZGENE, UniProtKB/TrEMBL
  A6HJ40_RAT UniProtKB/TrEMBL
  ACLY_RAT UniProtKB/Swiss-Prot
  G3V888 ENTREZGENE, UniProtKB/TrEMBL
  G3V9G4 ENTREZGENE, UniProtKB/TrEMBL
  P16638 ENTREZGENE
  Q497C7 ENTREZGENE
  Q8VIQ1 ENTREZGENE
UniProt Secondary Q497C7 UniProtKB/Swiss-Prot
  Q8VIQ1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Acly  ATP citrate lyase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression protein detected in adipocytes 631762
gene_expression mRNA and active enzyme detected in liver 631747
gene_expression mRNA expression in liver is high at birth, decreases during suckling, and is higher in adults 631747
gene_function substrate for protein kinase B in adipocytes 631762
gene_function catalyzes the synthesis of cytosolic acetyl-CoA 631747
gene_process plays a role in lipid and cholesterol metabolism 631747
gene_regulation phosphorylated at Ser454 by protein kinase B in adipocytes 631762
gene_regulation increased mRNA expression is detected in rats fed a low fat, high carbohydrate diet 631747
gene_transcript mRNA is 4.3 kb in size 631747