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Gene: Itgb3 (integrin subunit beta 3) Rattus norvegicus
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Symbol: Itgb3
Name: integrin subunit beta 3
Description: Contributes to fibrinogen binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of signal transduction; and positive regulation of vasculature development. Localizes to the apical plasma membrane; cell surface; and integrin complex. Colocalizes with the focal adhesion. Used to study myocardial infarction. Biomarker of bacterial pneumonia; glomerulonephritis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal failure; non-arteritic anterior ischemic optic neuropathy; and platelet-type bleeding disorder 16. Orthologous to human ITGB3 (integrin subunit beta 3); PARTICIPATES IN integrin mediated signaling pathway; abciximab pharmacodynamics pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH (+)-pilocarpine; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: GPIIIa; integrin beta 3; integrin beta 3 (Cd61); integrin beta-3; integrin, beta 3; platelet membrane glycoprotein IIIa
Orthologs:
Homo sapiens (human) : ITGB3 (integrin subunit beta 3)  HGNC  Alliance
Mus musculus (house mouse) : Itgb3 (integrin beta 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb3 (integrin subunit beta 3)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB3 (integrin subunit beta 3)
Canis lupus familiaris (dog) : ITGB3 (integrin subunit beta 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb3 (integrin subunit beta 3)
Sus scrofa (pig) : ITGB3 (integrin subunit beta 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01092,667,869 - 92,783,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01092,424,545 - 92,538,859 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1088,202,821 - 88,257,185 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Itgb3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628868
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.