G6pc1 (glucose-6-phosphatase catalytic subunit 1) - Rat Genome Database

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Gene: G6pc1 (glucose-6-phosphatase catalytic subunit 1) Rattus norvegicus
Analyze
Symbol: G6pc1
Name: glucose-6-phosphatase catalytic subunit 1
RGD ID: 2644
Description: Enables glucose-6-phosphatase activity. Involved in several processes, including cellular response to insulin stimulus; gluconeogenesis; and response to resveratrol. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of proteasome activator complex. Predicted to be active in endoplasmic reticulum and membrane. Used to study type 2 diabetes mellitus. Biomarker of steatotic liver disease. Human ortholog(s) of this gene implicated in glycogen storage disease Ia and hepatocellular carcinoma. Orthologous to human G6PC1 (glucose-6-phosphatase catalytic subunit 1); PARTICIPATES IN altered galactose metabolic pathway; gluconeogenesis pathway; Fanconi syndrome pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,2-dimethylhydrazine; 1-benzylpiperazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AC123346.1; G-6-Pase; G6PASE; G6pc; Glucose-6-phosphatase; glucose-6-phosphatase, catalytic; glucose-6-phosphatase, catalytic subunit; MGC93613; proteasome activator subunit 3; Psme3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,807,659 - 86,819,023 (+)NCBIGRCr8
mRatBN7.21086,307,400 - 86,318,766 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,257,668 - 86,333,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,345,012 - 91,356,309 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,819,762 - 90,831,058 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,213,072 - 86,224,369 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,286,009 - 89,296,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,285,855 - 89,296,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,084,064 - 89,094,265 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,393,531 - 90,403,485 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,407,938 - 90,417,855 (+)NCBI
Celera1085,025,492 - 85,036,580 (+)NCBICelera
RH 3.4 Map10837.1RGD
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (ISO)
(aminooxy)acetic acid  (ISO)
(E)-thiamethoxam  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(4-hydroxyphenyl)ethanol  (EXP)
2-acetamidofluorene  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (ISO)
4-nitrophenol  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acephate  (EXP)
acetyl-CoA  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucose  (EXP,ISO)
alloxan  (EXP)
aluminium phosphide  (EXP)
AM-251  (ISO)
ammonium chloride  (EXP)
anthracen-2-amine  (EXP)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
azoxystrobin  (ISO)
bacitracin  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
betulin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (ISO)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbamazepine  (EXP)
carbendazim  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloroacetic acid  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
citronellol  (EXP)
clemizole  (ISO)
clofibrate  (EXP,ISO)
clopidogrel  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cyprodinil  (ISO)
D-glucopyranose 6-phosphate  (ISO)
D-glucose  (EXP,ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethyl maleate  (ISO)
difenoconazole  (ISO)
digoxigenin  (ISO)
dihydroouabain  (ISO)
dimethomorph  (ISO)
Diosbulbin B  (ISO)
disodium selenite  (EXP,ISO)
doramapimod  (ISO)
duvoglustat  (ISO)
ebselen  (EXP)
endosulfan  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethoprophos  (ISO)
felbamate  (EXP)
fenofibrate  (ISO)
fenpyroximate  (ISO)
fipronil  (ISO)
fludioxonil  (ISO)
fluoxetine  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
fluxapyroxad  (ISO)
folic acid  (ISO)
folpet  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furan  (EXP)
gabapentin  (EXP)
gentamycin  (EXP)
ginsenoside Re  (ISO)
glafenine  (EXP)
glucagon  (EXP)
glucose  (EXP,ISO)
glyburide  (EXP)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ketoconazole  (EXP)
L-methionine  (ISO)
lamivudine  (ISO)
Lasiocarpine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
mercury dichloride  (EXP)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methoxyacetic acid  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
Muraglitazar  (EXP)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naringin  (ISO)
nefazodone  (EXP)
nickel dichloride  (EXP)
nicotinamide  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
penconazole  (ISO)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (EXP)
PhIP  (ISO)
phlorizin  (EXP)
pirinixic acid  (ISO)
plumbagin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
strophanthidin  (ISO)
sucrose  (EXP)
sulconazole  (ISO)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP)
tebuconazole  (ISO)
teriflunomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
tungstate  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (EXP,ISO)
vanillic acid  (ISO)
vanillin  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)
xanthosine  (EXP)
xylitol  (ISO)
zidovudine  (ISO)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. Alauddin M, etal., BMC Complement Altern Med. 2016 Nov 8;16(1):442. doi: 10.1186/s12906-016-1427-z.
2. Liver glyconeogenesis: a pathway to cope with postprandial amino acid excess in high-protein fed rats? Azzout-Marniche D, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1400-7. doi: 10.1152/ajpregu.00566.2006. Epub 2006 Dec 7.
3. Gossypol ameliorates liver fibrosis in diabetic rats induced by high-fat diet and streptozocin. Chen G, etal., Life Sci. 2016 Mar 15;149:58-64. doi: 10.1016/j.lfs.2016.02.044. Epub 2016 Feb 13.
4. Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy. Clar J, etal., Kidney Int. 2014 Oct;86(4):747-56. doi: 10.1038/ki.2014.102. Epub 2014 Apr 9.
5. Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes. Clore JN, etal., Diabetes. 2000 Jun;49(6):969-74.
6. Intrinsic gluconeogenesis is enhanced in renal proximal tubules of Zucker diabetic fatty rats. Eid A, etal., J Am Soc Nephrol. 2006 Feb;17(2):398-405. Epub 2006 Jan 5.
7. Defect in glucokinase translocation in Zucker diabetic fatty rats. Fujimoto Y, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Fasting for 3 days during the suckling-weaning transient period in male rats induces metabolic abnormalities in the liver and is associated with impaired glucose tolerance in adulthood. Ikeda M, etal., Eur J Nutr. 2016 Apr;55(3):1059-67. doi: 10.1007/s00394-015-0919-9. Epub 2015 May 6.
11. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
12. Kinetic properties of the glucose 6-phosphatase of the liver from arthritic rats. Kelmer-Bracht AM, etal., Biochim Biophys Acta. 2003 May 20;1638(1):50-6.
13. Glycogen storage disease type Ia mice with less than 2% of normal hepatic glucose-6-phosphatase-α activity restored are at risk of developing hepatic tumors. Kim GY, etal., Mol Genet Metab. 2017 Mar;120(3):229-234. doi: 10.1016/j.ymgme.2017.01.003. Epub 2017 Jan 10.
14. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Kong Q, etal., Int J Mol Med. 2016 Dec;38(6):1715-1726. doi: 10.3892/ijmm.2016.2799. Epub 2016 Nov 10.
15. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
16. Isolation of a cDNA for the catalytic subunit of rat liver glucose-6-phosphatase: regulation of gene expression in FAO hepatoma cells by insulin, dexamethasone and cAMP. Lange AJ, etal., Biochem Biophys Res Commun 1994 May 30;201(1):302-9.
17. Saccharin Increases Fasting Blood Glucose but Not Liver Insulin Resistance in Comparison to a High Fructose-Fed Rat Model. Leibowitz A, etal., Nutrients. 2018 Mar 12;10(3). pii: nu10030341. doi: 10.3390/nu10030341.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context. Monteillet L, etal., Mol Metab. 2018 Oct;16:100-115. doi: 10.1016/j.molmet.2018.07.006. Epub 2018 Aug 1.
20. Regulation of glucose-6-phosphatase gene expression by insulin and metformin. Mues C, etal., Horm Metab Res. 2009 Oct;41(10):730-5. doi: 10.1055/s-0029-1225360. Epub 2009 Jul 3.
21. Glucose-6-phosphatase gene mutations in 20 adult Japanese patients with glycogen storage disease type 1a with reference to hepatic tumors. Nakamura T, etal., J Gastroenterol Hepatol. 2001 Dec;16(12):1402-8.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease. Nishikawa T, etal., J Hepatol. 2014 Jun;60(6):1203-11. doi: 10.1016/j.jhep.2014.02.014. Epub 2014 Feb 26.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
26. Enhanced trimethylation of histone h3 mediates impaired expression of hepatic glucose 6-phosphatase expression in offspring from rat dams exposed to hypoxia during pregnancy. Osumek JE, etal., Reprod Sci. 2014 Jan;21(1):112-21. doi: 10.1177/1933719113492212. Epub 2013 Jun 6.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
30. Polyunsaturated fatty acyl coenzyme A suppress the glucose-6-phosphatase promoter activity by modulating the DNA binding of hepatocyte nuclear factor 4 alpha. Rajas F, etal., J Biol Chem 2002 May 3;277(18):15736-44.
31. Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats. Ramesh B, etal., J Med Food. 2005 Fall;8(3):377-81.
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Expression and distribution of glucose-6-phosphatase catalytic subunit messenger RNA and its changes in the diabetic state. Shingu R, etal., Res Commun Mol Pathol Pharmacol 1996 Jul;93(1):13-24.
36. Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin. Song S, etal., Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E275-82.
37. Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats. Trinh KY, etal., J Biol Chem. 1998 Nov 20;273(47):31615-20.
38. DYRK1 is a co-activator of FKHR (FOXO1a)-dependent glucose-6-phosphatase gene expression. von Groote-Bidlingmaier F, etal., Biochem Biophys Res Commun 2003 Jan 17;300(3):764-9.
39. Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation. Vuguin P, etal., Diabetes. 2004 Oct;53(10):2617-22.
40. 1,2-Dichloroethane impairs glucose and lipid homeostasis in the livers of NIH Swiss mice. Wang T, etal., Toxicology. 2017 Apr 1;380:38-49. doi: 10.1016/j.tox.2017.02.005. Epub 2017 Feb 8.
41. An acute increase in fructose concentration increases hepatic glucose-6-phosphatase mRNA via mechanisms that are independent of glycogen synthase kinase-3 in rats. Wei Y, etal., J Nutr. 2004 Mar;134(3):545-51.
42. Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
43. Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice. Yamashita H, etal., Pediatr Res. 2003 Mar;53(3):411-8.
44. Complete normalization of hepatic G6PC deficiency in murine glycogen storage disease type Ia using gene therapy. Yiu WH, etal., Mol Ther. 2010 Jun;18(6):1076-84. doi: 10.1038/mt.2010.64. Epub 2010 Apr 13.
45. Resveratrol improves glycemic control in insulin-treated diabetic rats: participation of the hepatic territory. Yonamine CY, etal., Nutr Metab (Lond). 2016 Jun 29;13:44. doi: 10.1186/s12986-016-0103-0. eCollection 2016.
46. Gluconeogenesis in developing rat kidney cortex. Zorzoli A, etal., Biochem J. 1969 Jan;111(2):181-5.
Additional References at PubMed
PMID:7860767   PMID:8211187   PMID:8407995   PMID:8640227   PMID:8866562   PMID:10318794   PMID:10625614   PMID:10787428   PMID:11121425   PMID:11882511   PMID:12093795   PMID:12477932  
PMID:12902328   PMID:12915406   PMID:14759518   PMID:15087461   PMID:15302872   PMID:15388792   PMID:15661744   PMID:15682487   PMID:15735652   PMID:16256938   PMID:16893891   PMID:17106062  
PMID:17160355   PMID:17211624   PMID:17588937   PMID:17931592   PMID:18304430   PMID:18717264   PMID:21402051   PMID:22214556   PMID:31904090  


Genomics

Comparative Map Data
G6pc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,807,659 - 86,819,023 (+)NCBIGRCr8
mRatBN7.21086,307,400 - 86,318,766 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,257,668 - 86,333,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,345,012 - 91,356,309 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,819,762 - 90,831,058 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,213,072 - 86,224,369 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,286,009 - 89,296,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,285,855 - 89,296,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,084,064 - 89,094,265 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,393,531 - 90,403,485 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,407,938 - 90,417,855 (+)NCBI
Celera1085,025,492 - 85,036,580 (+)NCBICelera
RH 3.4 Map10837.1RGD
Cytogenetic Map10q31NCBI
G6PC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,900,799 - 42,914,438 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,900,797 - 42,914,438 (+)EnsemblGRCh38hg38GRCh38
GRCh371741,052,816 - 41,066,455 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,306,341 - 38,318,912 (+)NCBINCBI36Build 36hg18NCBI36
Build 341738,306,340 - 38,318,912NCBI
Celera1737,708,948 - 37,721,525 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1736,817,624 - 36,831,212 (+)NCBIHuRef
CHM1_11741,288,425 - 41,302,053 (+)NCBICHM1_1
T2T-CHM13v2.01743,757,942 - 43,771,581 (+)NCBIT2T-CHM13v2.0
G6pc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,258,542 - 101,268,729 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,258,387 - 101,268,729 (+)EnsemblGRCm39 Ensembl
GRCm3811101,367,716 - 101,377,903 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,367,561 - 101,377,903 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711101,229,044 - 101,239,217 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,183,820 - 101,193,993 (+)NCBIMGSCv36mm8
MGSCv3611102,147,317 - 102,157,491 (+)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1164.83NCBI
G6pc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,672,979 - 16,680,001 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,672,512 - 16,680,001 (+)NCBIChiLan1.0ChiLan1.0
G6PC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,072,152 - 22,087,542 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11723,961,401 - 23,976,773 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,407,355 - 14,419,660 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,635,667 - 14,646,674 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,635,667 - 14,646,674 (-)Ensemblpanpan1.1panPan2
G6PC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,132,973 - 20,143,642 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,132,978 - 20,143,642 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,594,513 - 19,605,089 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,851,596 - 20,862,184 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,852,175 - 20,862,060 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,636,449 - 19,647,026 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,902,743 - 19,913,338 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,005,407 - 20,015,994 (-)NCBIUU_Cfam_GSD_1.0
G6pc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,459,203 - 19,469,287 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,605,865 - 17,615,145 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,605,865 - 17,614,754 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
G6PC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,965,330 - 19,975,857 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,965,885 - 19,975,783 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
G6PC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,380,921 - 63,392,122 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,381,382 - 63,391,540 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,170,149 - 34,181,234 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
G6pc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,331,601 - 1,339,580 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,331,592 - 1,339,575 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in G6pc1
64 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat

Markers in Region
RH129533  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,318,480 - 86,318,677 (+)MAPPERmRatBN7.2
Rnor_6.01089,295,928 - 89,296,124NCBIRnor6.0
Rnor_5.01089,093,980 - 89,094,176UniSTSRnor5.0
RH 3.4 Map10838.0UniSTS
Cytogenetic Map10q32.1UniSTS
RH94788  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21086,317,643 - 86,317,842 (+)MAPPERmRatBN7.2
Rnor_6.01089,295,091 - 89,295,289NCBIRnor6.0
Rnor_5.01089,093,143 - 89,093,341UniSTSRnor5.0
RGSC_v3.41090,403,147 - 90,403,345UniSTSRGSC3.4
Celera1085,035,807 - 85,036,005UniSTS
RH 3.4 Map10837.1UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 23 23 23
Low 1 9 4 6 4 2 2 6 6 5 2
Below cutoff 2 17 19 8 13 8 6 6 21 2 29 6 6

Sequence


RefSeq Acc Id: ENSRNOT00000027957   ⟹   ENSRNOP00000027957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,257,668 - 86,265,444 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000028033   ⟹   ENSRNOP00000028033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,307,438 - 86,318,420 (+)Ensembl
Rnor_6.0 Ensembl1089,285,855 - 89,296,213 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1089,286,061 - 89,288,641 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076727   ⟹   ENSRNOP00000068494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,257,694 - 86,265,460 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076820   ⟹   ENSRNOP00000068449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,257,872 - 86,333,804 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077603   ⟹   ENSRNOP00000070071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,257,872 - 86,317,581 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085831   ⟹   ENSRNOP00000071453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,307,438 - 86,318,420 (+)Ensembl
Rnor_6.0 Ensembl1089,286,047 - 89,295,867 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000101325   ⟹   ENSRNOP00000091678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,257,694 - 86,265,460 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117234   ⟹   ENSRNOP00000080141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1086,258,383 - 86,265,460 (+)Ensembl
RefSeq Acc Id: NM_013098   ⟹   NP_037230
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,807,659 - 86,819,023 (+)NCBI
mRatBN7.21086,307,400 - 86,318,766 (+)NCBI
Rnor_6.01089,286,009 - 89,296,213 (+)NCBI
Rnor_5.01089,084,064 - 89,094,265 (+)NCBI
RGSC_v3.41090,393,531 - 90,403,485 (+)RGD
Celera1085,025,492 - 85,036,580 (+)RGD
Sequence:
RefSeq Acc Id: NP_037230   ⟸   NM_013098
- UniProtKB: Q5FVC9 (UniProtKB/Swiss-Prot),   P43428 (UniProtKB/Swiss-Prot),   A6HJB1 (UniProtKB/TrEMBL),   A0A8L2QF08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028033   ⟸   ENSRNOT00000028033
RefSeq Acc Id: ENSRNOP00000071453   ⟸   ENSRNOT00000085831
RefSeq Acc Id: ENSRNOP00000068494   ⟸   ENSRNOT00000076727
RefSeq Acc Id: ENSRNOP00000091678   ⟸   ENSRNOT00000101325
RefSeq Acc Id: ENSRNOP00000070071   ⟸   ENSRNOT00000077603
RefSeq Acc Id: ENSRNOP00000068449   ⟸   ENSRNOT00000076820
RefSeq Acc Id: ENSRNOP00000080141   ⟸   ENSRNOT00000117234
RefSeq Acc Id: ENSRNOP00000027957   ⟸   ENSRNOT00000027957
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43428-F1-model_v2 AlphaFold P43428 1-357 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697756
Promoter ID:EPDNEW_R8281
Type:single initiation site
Name:G6pc_1
Description:glucose-6-phosphatase, catalytic subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01089,285,998 - 89,286,058EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2644 AgrOrtholog
BioCyc Gene G2FUF-23176 BioCyc
BioCyc Pathway PWY66-399 [gluconeogenesis III] BioCyc
BioCyc Pathway Image PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000051171 Ensembl
  ENSRNOG00000053448 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055033526 UniProtKB/Swiss-Prot
  ENSRNOG00060015588 UniProtKB/Swiss-Prot
  ENSRNOG00065033341 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028033.7 UniProtKB/TrEMBL
  ENSRNOT00000076727.2 UniProtKB/TrEMBL
  ENSRNOT00000076820.2 UniProtKB/TrEMBL
  ENSRNOT00000077603.2 UniProtKB/TrEMBL
  ENSRNOT00000085831 ENTREZGENE
  ENSRNOT00000085831.2 UniProtKB/Swiss-Prot
  ENSRNOT00000117234.1 UniProtKB/TrEMBL
  ENSRNOT00055057948 UniProtKB/Swiss-Prot
  ENSRNOT00060026706 UniProtKB/Swiss-Prot
  ENSRNOT00065057318 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.180 UniProtKB/TrEMBL
  1.20.5.120 UniProtKB/TrEMBL
  2.70.98.20 UniProtKB/TrEMBL
  3.10.450.40 UniProtKB/TrEMBL
  Phosphatidic acid phosphatase type 2/haloperoxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7109006 IMAGE-MGC_LOAD
InterPro Cu_amine_oxidase UniProtKB/TrEMBL
  Cu_amine_oxidase_C UniProtKB/TrEMBL
  Cu_amine_oxidase_C_sf UniProtKB/TrEMBL
  Cu_amine_oxidase_N-reg UniProtKB/TrEMBL
  Cu_amine_oxidase_N2 UniProtKB/TrEMBL
  Cu_amine_oxidase_N3 UniProtKB/TrEMBL
  Glucose-6-phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_Acid_Pase_2/haloperoxi_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_Acid_Pase_2/haloperoxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PA28_C UniProtKB/TrEMBL
  PA28_C_sf UniProtKB/TrEMBL
  PA28_N_sf UniProtKB/TrEMBL
  Proteasome_activ_PA28 UniProtKB/TrEMBL
  Proteasome_activ_PA28_N UniProtKB/TrEMBL
  Proteasome_activ_sf UniProtKB/TrEMBL
KEGG Report rno:25634 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93613 IMAGE-MGC_LOAD
NCBI Gene 25634 ENTREZGENE
PANTHER GLUCOSE-6-PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MEMBRANE PRIMARY AMINE OXIDASE UniProtKB/TrEMBL
  PROTEASOME ACTIVATOR COMPLEX SUBUNIT 3 UniProtKB/TrEMBL
  PROTEASOME ACTIVATOR SUBUNIT 3 UniProtKB/TrEMBL
  PTHR10638 UniProtKB/TrEMBL
  PTHR10660 UniProtKB/TrEMBL
Pfam Cu_amine_oxid UniProtKB/TrEMBL
  Cu_amine_oxidN2 UniProtKB/TrEMBL
  Cu_amine_oxidN3 UniProtKB/TrEMBL
  PA28_alpha UniProtKB/TrEMBL
  PA28_beta UniProtKB/TrEMBL
  PAP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen G6pc1 PhenoGen
PIRSF Glucose-6-phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CUDAOXIDASE UniProtKB/TrEMBL
PROSITE COPPER_AMINE_OXID_1 UniProtKB/TrEMBL
  COPPER_AMINE_OXID_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051171 RatGTEx
  ENSRNOG00000053448 RatGTEx
  ENSRNOG00055033526 RatGTEx
  ENSRNOG00060015588 RatGTEx
  ENSRNOG00065033341 RatGTEx
SMART acidPPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47216 UniProtKB/TrEMBL
  SSF48317 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49998 UniProtKB/TrEMBL
  SSF54416 UniProtKB/TrEMBL
UniProt A0A096MKF4_RAT UniProtKB/TrEMBL
  A0A0G2JWZ2_RAT UniProtKB/TrEMBL
  A0A8I5ZP59_RAT UniProtKB/TrEMBL
  A0A8L2QF08 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R069_RAT UniProtKB/TrEMBL
  A6HJB1 ENTREZGENE, UniProtKB/TrEMBL
  G6PC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5FVC9 ENTREZGENE
UniProt Secondary Q5FVC9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 G6pc1  glucose-6-phosphatase catalytic subunit 1  AC123346.1    Data merged from RGD:15007920 737654 PROVISIONAL
2021-09-02 AC123346.1    Psme3  proteasome activator subunit 3  Symbol and/or name change 19259462 PROVISIONAL
2021-08-09 Psme3  proteasome activator subunit 3  AC123346.1    Symbol and/or name change 19259462 PROVISIONAL
2020-11-12 G6pc1  glucose-6-phosphatase catalytic subunit 1  G6pc  glucose-6-phosphatase, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-11-08 AC123346.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2008-09-18 G6pc  glucose-6-phosphatase, catalytic subunit  G6pc  glucose-6-phosphatase, catalytic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 G6pc  glucose-6-phosphatase, catalytic    Glucose-6-phosphatase  Name updated 625702 APPROVED
2002-06-10 G6pc  Glucose-6-phosphatase      Symbol and Name status set to approved 70586 APPROVED