G6pc1 (glucose-6-phosphatase catalytic subunit 1) - Rat Genome Database

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Gene: G6pc1 (glucose-6-phosphatase catalytic subunit 1) Mus musculus
Analyze
Symbol: G6pc1 (Ensembl: G6pc)
Name: glucose-6-phosphatase catalytic subunit 1 (Ensembl:glucose-6-phosphatase, catalytic)
RGD ID: 733336
MGI Page MGI
Description: Enables glucose-6-phosphatase activity and phosphotransferase activity, alcohol group as acceptor. Involved in gluconeogenesis. Acts upstream of or within several processes, including cholesterol homeostasis; glucose-6-phosphate transport; and glycogen catabolic process. Is active in endoplasmic reticulum. Is expressed in embryo; liver; metanephros; and small intestine. Used to study glycogen storage disease Ia. Human ortholog(s) of this gene implicated in glycogen storage disease Ia; hepatocellular carcinoma; and type 2 diabetes mellitus. Orthologous to human G6PC1 (glucose-6-phosphatase catalytic subunit 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AW107337; G-6-Pase; G6P; G6Pase; G6pc; G6pt; Glc-6-; Glc-6-Pase; Glc-6-Pase-alpha; glucose-6-phosphatase; glucose-6-phosphatase, catalytic
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,258,542 - 101,268,729 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,258,387 - 101,268,729 (+)EnsemblGRCm39 Ensembl
GRCm3811101,367,716 - 101,377,903 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,367,561 - 101,377,903 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711101,229,044 - 101,239,217 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,183,820 - 101,193,993 (+)NCBIMGSCv36mm8
MGSCv3611102,147,317 - 102,157,491 (+)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1164.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(1->4)-beta-D-glucan  (EXP)
(aminooxy)acetic acid  (EXP)
(E)-thiamethoxam  (ISO)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-benzylpiperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-(4-hydroxyphenyl)ethanol  (ISO)
2-acetamidofluorene  (ISO)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside  (EXP)
4-nitrophenol  (EXP)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acephate  (ISO)
acetyl-CoA  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alloxan  (ISO)
aluminium phosphide  (ISO)
AM-251  (EXP)
ammonium chloride  (ISO)
anthracen-2-amine  (ISO)
arachidonyl-2'-chloroethylamide  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atorvastatin calcium  (ISO)
azoxystrobin  (ISO)
bacitracin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (EXP)
betulin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bosentan  (ISO)
bucladesine  (EXP)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
carbamazepine  (ISO)
carbendazim  (ISO)
cefaloridine  (ISO)
chloroacetic acid  (EXP)
chlorpyrifos  (ISO)
choline  (EXP)
chromium(6+)  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
citronellol  (ISO)
clemizole  (ISO)
clofibrate  (EXP,ISO)
clopidogrel  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cyprodinil  (ISO)
D-glucopyranose 6-phosphate  (EXP)
D-glucose  (EXP,ISO)
dehydroepiandrosterone  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP)
diethyl maleate  (EXP,ISO)
difenoconazole  (ISO)
digoxigenin  (ISO)
dihydroouabain  (ISO)
dimethomorph  (ISO)
Diosbulbin B  (EXP)
disodium selenite  (EXP,ISO)
doramapimod  (EXP)
duvoglustat  (EXP)
ebselen  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
epoxiconazole  (EXP,ISO)
erythromycin estolate  (ISO)
esculetin  (EXP)
ethanol  (EXP,ISO)
ethoprophos  (ISO)
felbamate  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
fipronil  (ISO)
fludioxonil  (ISO)
fluoxetine  (EXP,ISO)
flusilazole  (ISO)
flutamide  (ISO)
fluvastatin  (ISO)
fluxapyroxad  (ISO)
folic acid  (EXP)
folpet  (EXP)
fructose  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gabapentin  (ISO)
gentamycin  (ISO)
ginsenoside Re  (ISO)
glafenine  (ISO)
glucagon  (ISO)
glucose  (EXP,ISO)
glyburide  (ISO)
GW 4064  (EXP)
hexadecanoic acid  (EXP)
indole-3-methanol  (ISO)
inulin  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
ketoconazole  (ISO)
L-methionine  (EXP)
lamivudine  (EXP)
Lasiocarpine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
maneb  (ISO)
MeIQ  (ISO)
MeIQx  (ISO)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methapyrilene  (ISO)
methoxyacetic acid  (ISO)
methylmercury chloride  (EXP)
microcystin-LR  (EXP)
mifepristone  (ISO)
Mitotane  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
Muraglitazar  (ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naringin  (EXP)
nefazodone  (ISO)
nickel dichloride  (ISO)
nicotinamide  (EXP)
nitrofen  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oleic acid  (EXP)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
penconazole  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
PhIP  (ISO)
phlorizin  (ISO)
pirinixic acid  (EXP)
plumbagin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (ISO)
silicon dioxide  (EXP)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (EXP,ISO)
strophanthidin  (ISO)
sucrose  (ISO)
sulconazole  (ISO)
taurine  (EXP)
tauroursodeoxycholic acid  (ISO)
tebuconazole  (ISO)
teriflunomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thiamethoxam  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
titanium dioxide  (EXP)
tributylstannane  (EXP,ISO)
trichloroethene  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP,ISO)
triptonide  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
tungstate  (ISO)
tunicamycin  (EXP)
urethane  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (EXP,ISO)
vanillic acid  (ISO)
vanillin  (ISO)
withaferin A  (ISO)
wortmannin  (ISO)
xanthosine  (ISO)
xylitol  (EXP)
zidovudine  (EXP)
zinc dichloride  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood homeostasis  (IAGP)
abnormal cartilage development  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal hepatocyte morphology  (IAGP)
abnormal homeostasis  (IAGP)
abnormal joint morphology  (IAGP)
abnormal kidney cortex morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal lipid homeostasis  (IAGP)
abnormal liver sinusoid morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal renal tubule epithelium morphology  (IAGP)
abnormal renal tubule morphology  (IAGP)
abnormal urine homeostasis  (IAGP)
decreased body size  (IAGP)
decreased circulating glucose level  (IAGP)
decreased urine pH  (IAGP)
dilated renal tubule  (IAGP)
enlarged kidney  (IAGP)
enlarged liver  (IAGP)
hepatic necrosis  (IAGP)
hepatic steatosis  (IAGP)
hypoglycemia  (IAGP)
increased blood uric acid level  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased kidney glycogen level  (IAGP)
increased kidney weight  (IAGP)
increased liver adenoma incidence  (IAGP)
increased liver glycogen level  (IAGP)
increased liver triglyceride level  (IAGP)
increased liver weight  (IAGP)
increased urine magnesium level  (IAGP)
increased urine microalbumin level  (IAGP)
increased urine phosphate level  (IAGP)
increased urine uric acid level  (IAGP)
pale liver  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
renal glomerulus atrophy  (IAGP)
renal tubule atrophy  (IAGP)
seizures  (IAGP)
slow postnatal weight gain  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats. Alauddin M, etal., BMC Complement Altern Med. 2016 Nov 8;16(1):442. doi: 10.1186/s12906-016-1427-z.
2. Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy. Clar J, etal., Kidney Int. 2014 Oct;86(4):747-56. doi: 10.1038/ki.2014.102. Epub 2014 Apr 9.
3. Glucose-6-phosphatase flux in vitro is increased in type 2 diabetes. Clore JN, etal., Diabetes. 2000 Jun;49(6):969-74.
4. Intrinsic gluconeogenesis is enhanced in renal proximal tubules of Zucker diabetic fatty rats. Eid A, etal., J Am Soc Nephrol. 2006 Feb;17(2):398-405. Epub 2006 Jan 5.
5. Defect in glucokinase translocation in Zucker diabetic fatty rats. Fujimoto Y, etal., Am J Physiol Endocrinol Metab. 2004 Sep;287(3):E414-23. Epub 2004 May 11.
6. Glycogen storage disease type Ia mice with less than 2% of normal hepatic glucose-6-phosphatase-α activity restored are at risk of developing hepatic tumors. Kim GY, etal., Mol Genet Metab. 2017 Mar;120(3):229-234. doi: 10.1016/j.ymgme.2017.01.003. Epub 2017 Jan 10.
7. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Kong Q, etal., Int J Mol Med. 2016 Dec;38(6):1715-1726. doi: 10.3892/ijmm.2016.2799. Epub 2016 Nov 10.
8. Saccharin Increases Fasting Blood Glucose but Not Liver Insulin Resistance in Comparison to a High Fructose-Fed Rat Model. Leibowitz A, etal., Nutrients. 2018 Mar 12;10(3). pii: nu10030341. doi: 10.3390/nu10030341.
9. Cloning and characterization of cDNAs encoding a candidate glycogen storage disease type 1b protein in rodents. Lin B, etal., J Biol Chem 1998 Nov 27;273(48):31656-60.
10. Cloning and characterization of the human and rat islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) genes. Martin CC, etal., J Biol Chem 2001 Jul 6;276(27):25197-207.
11. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
12. MGDs mouse GO annotations MGD data from the GO Consortium
13. MGD IEA MGD IEA
14. Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context. Monteillet L, etal., Mol Metab. 2018 Oct;16:100-115. doi: 10.1016/j.molmet.2018.07.006. Epub 2018 Aug 1.
15. Glucose-6-phosphatase gene mutations in 20 adult Japanese patients with glycogen storage disease type 1a with reference to hepatic tumors. Nakamura T, etal., J Gastroenterol Hepatol. 2001 Dec;16(12):1402-8.
16. A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease. Nishikawa T, etal., J Hepatol. 2014 Jun;60(6):1203-11. doi: 10.1016/j.jhep.2014.02.014. Epub 2014 Feb 26.
17. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. Enhanced trimethylation of histone h3 mediates impaired expression of hepatic glucose 6-phosphatase expression in offspring from rat dams exposed to hypoxia during pregnancy. Osumek JE, etal., Reprod Sci. 2014 Jan;21(1):112-21. doi: 10.1177/1933719113492212. Epub 2013 Jun 6.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
23. Influence of sesame oil on blood glucose, lipid peroxidation, and antioxidant status in streptozotocin diabetic rats. Ramesh B, etal., J Med Food. 2005 Fall;8(3):377-81.
24. Mouse MP Annotation Import Pipeline RGD automated import pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Expression and distribution of glucose-6-phosphatase catalytic subunit messenger RNA and its changes in the diabetic state. Shingu R, etal., Res Commun Mol Pathol Pharmacol 1996 Jul;93(1):13-24.
28. Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin. Song S, etal., Am J Physiol Endocrinol Metab. 2001 Aug;281(2):E275-82.
29. Hepatic insulin resistance precedes the development of diabetes in a model of intrauterine growth retardation. Vuguin P, etal., Diabetes. 2004 Oct;53(10):2617-22.
30. 1,2-Dichloroethane impairs glucose and lipid homeostasis in the livers of NIH Swiss mice. Wang T, etal., Toxicology. 2017 Apr 1;380:38-49. doi: 10.1016/j.tox.2017.02.005. Epub 2017 Feb 8.
31. Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
32. Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice. Yamashita H, etal., Pediatr Res. 2003 Mar;53(3):411-8.
33. Complete normalization of hepatic G6PC deficiency in murine glycogen storage disease type Ia using gene therapy. Yiu WH, etal., Mol Ther. 2010 Jun;18(6):1076-84. doi: 10.1038/mt.2010.64. Epub 2010 Apr 13.
34. Resveratrol improves glycemic control in insulin-treated diabetic rats: participation of the hepatic territory. Yonamine CY, etal., Nutr Metab (Lond). 2016 Jun 29;13:44. doi: 10.1186/s12986-016-0103-0. eCollection 2016.
35. Gluconeogenesis in developing rat kidney cortex. Zorzoli A, etal., Biochem J. 1969 Jan;111(2):181-5.
Additional References at PubMed
PMID:7628695   PMID:8099313   PMID:8407995   PMID:8640227   PMID:9115220   PMID:9507200   PMID:9689059   PMID:9750160   PMID:10049364   PMID:10078553   PMID:10205167   PMID:10349636  
PMID:10625614   PMID:10766845   PMID:10787428   PMID:11042159   PMID:11076861   PMID:11121425   PMID:11217851   PMID:12189168   PMID:12416993   PMID:12477932   PMID:12754525   PMID:12819187  
PMID:12878201   PMID:12925567   PMID:14662765   PMID:14668353   PMID:14681479   PMID:14759518   PMID:15087461   PMID:15178647   PMID:15578515   PMID:15661744   PMID:15735652   PMID:15744310  
PMID:16141072   PMID:16141073   PMID:16288022   PMID:17203215   PMID:17438133   PMID:17588937   PMID:17659284   PMID:17937387   PMID:18075499   PMID:18478268   PMID:18563384   PMID:18805788  
PMID:18847435   PMID:19015022   PMID:19039140   PMID:19185577   PMID:19419892   PMID:19548314   PMID:19581879   PMID:19923254   PMID:20195241   PMID:21081500   PMID:21109326   PMID:21184805  
PMID:21267068   PMID:21402089   PMID:21873635   PMID:22013018   PMID:22075642   PMID:22874919   PMID:23260145   PMID:23386589   PMID:23596325   PMID:23623482   PMID:23856420   PMID:24412651  
PMID:24569808   PMID:24874427   PMID:25061558   PMID:25147298   PMID:25561689   PMID:25685698   PMID:26089201   PMID:26220403   PMID:26919869   PMID:27069866   PMID:27146480   PMID:27215380  
PMID:27428080   PMID:27436577   PMID:27626668   PMID:27631137   PMID:27631554   PMID:27689697   PMID:27754788   PMID:27904043   PMID:28245920   PMID:28317891   PMID:28340340   PMID:28558013  
PMID:28622511   PMID:28749080   PMID:29428299   PMID:29530977   PMID:29545180   PMID:29784585   PMID:30256948   PMID:30733279   PMID:30818059   PMID:30898969   PMID:31524221   PMID:31735334  
PMID:31813960   PMID:31961433   PMID:32430177   PMID:32620541   PMID:32798765   PMID:33137488   PMID:33359667   PMID:34035281   PMID:34091064   PMID:34599818   PMID:35008754   PMID:35082330  
PMID:35377412   PMID:36421460   PMID:36870604   PMID:37855366   PMID:37871105   PMID:38042368  


Genomics

Comparative Map Data
G6pc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,258,542 - 101,268,729 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,258,387 - 101,268,729 (+)EnsemblGRCm39 Ensembl
GRCm3811101,367,716 - 101,377,903 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,367,561 - 101,377,903 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711101,229,044 - 101,239,217 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611101,183,820 - 101,193,993 (+)NCBIMGSCv36mm8
MGSCv3611102,147,317 - 102,157,491 (+)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1164.83NCBI
G6PC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,900,799 - 42,914,438 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,900,797 - 42,914,438 (+)EnsemblGRCh38hg38GRCh38
GRCh371741,052,816 - 41,066,455 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,306,341 - 38,318,912 (+)NCBINCBI36Build 36hg18NCBI36
Build 341738,306,340 - 38,318,912NCBI
Celera1737,708,948 - 37,721,525 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1736,817,624 - 36,831,212 (+)NCBIHuRef
CHM1_11741,288,425 - 41,302,053 (+)NCBICHM1_1
T2T-CHM13v2.01743,757,942 - 43,771,581 (+)NCBIT2T-CHM13v2.0
G6pc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,807,659 - 86,819,023 (+)NCBIGRCr8
mRatBN7.21086,307,400 - 86,318,766 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1086,257,668 - 86,333,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1091,345,012 - 91,356,309 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,819,762 - 90,831,058 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,213,072 - 86,224,369 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,286,009 - 89,296,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,285,855 - 89,296,213 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,084,064 - 89,094,265 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,393,531 - 90,403,485 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,407,938 - 90,417,855 (+)NCBI
Celera1085,025,492 - 85,036,580 (+)NCBICelera
RH 3.4 Map10837.1RGD
Cytogenetic Map10q31NCBI
G6pc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,672,979 - 16,680,001 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,672,512 - 16,680,001 (+)NCBIChiLan1.0ChiLan1.0
G6PC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,072,152 - 22,087,542 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11723,961,401 - 23,976,773 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,407,355 - 14,419,660 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11714,635,667 - 14,646,674 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1714,635,667 - 14,646,674 (-)Ensemblpanpan1.1panPan2
G6PC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,132,973 - 20,143,642 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,132,978 - 20,143,642 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,594,513 - 19,605,089 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,851,596 - 20,862,184 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,852,175 - 20,862,060 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,636,449 - 19,647,026 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,902,743 - 19,913,338 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,005,407 - 20,015,994 (-)NCBIUU_Cfam_GSD_1.0
G6pc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,459,203 - 19,469,287 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,605,865 - 17,615,145 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,605,865 - 17,614,754 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
G6PC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1219,965,330 - 19,975,857 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11219,965,885 - 19,975,783 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
G6PC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,380,921 - 63,392,122 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,381,382 - 63,391,540 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,170,149 - 34,181,234 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
G6pc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,331,601 - 1,339,580 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,331,592 - 1,339,575 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in G6pc1
236 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:392
Count of miRNA genes:303
Interacting mature miRNAs:344
Transcripts:ENSMUST00000019469
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
13513919Heal56_mwound healing/ regeneration 56 (mouse)11101156468101540293Mouse

Markers in Region
AW107337  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,377,511 - 101,377,645UniSTSGRCm38
MGSCv3711101,238,825 - 101,238,959UniSTSGRCm37
Cytogenetic Map11DUniSTS
Whitehead/MRC_RH111354.3UniSTS
U00445  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,377,357 - 101,377,479UniSTSGRCm38
MGSCv3711101,238,671 - 101,238,793UniSTSGRCm37
Cytogenetic Map11DUniSTS
Whitehead/MRC_RH111351.18UniSTS
G6pc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,376,834 - 101,376,909UniSTSGRCm38
MGSCv3711101,238,148 - 101,238,223UniSTSGRCm37
Cytogenetic Map11DUniSTS
cM Map11 UniSTS
PMC209474P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,376,731 - 101,377,343UniSTSGRCm38
MGSCv3711101,238,045 - 101,238,657UniSTSGRCm37
Cytogenetic Map11DUniSTS
PMC86435P4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,367,781 - 101,368,020UniSTSGRCm38
MGSCv3711101,229,095 - 101,229,334UniSTSGRCm37
Cytogenetic Map11DUniSTS
G6pc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811101,377,560 - 101,377,639UniSTSGRCm38
MGSCv3711101,238,874 - 101,238,953UniSTSGRCm37
Cytogenetic Map11DUniSTS
G6pc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11DUniSTS
cM Map11 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000019469   ⟹   ENSMUSP00000019469
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11101,258,387 - 101,268,729 (+)Ensembl
GRCm38.p6 Ensembl11101,367,561 - 101,377,903 (+)Ensembl
RefSeq Acc Id: NM_008061   ⟹   NP_032087
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911101,258,542 - 101,268,729 (+)NCBI
GRCm3811101,367,716 - 101,377,903 (+)NCBI
MGSCv3711101,229,044 - 101,239,217 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032087 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52122 (Get FASTA)   NCBI Sequence Viewer  
  AAC53166 (Get FASTA)   NCBI Sequence Viewer  
  AAH13448 (Get FASTA)   NCBI Sequence Viewer  
  BAC34162 (Get FASTA)   NCBI Sequence Viewer  
  BAC35084 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000019469
  ENSMUSP00000019469.3
GenBank Protein P35576 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032087   ⟸   NM_008061
- UniProtKB: Q91WV3 (UniProtKB/Swiss-Prot),   P35576 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000019469   ⟸   ENSMUST00000019469

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35576-F1-model_v2 AlphaFold P35576 1-357 view protein structure

Promoters
RGD ID:6820905
Promoter ID:MM_KWN:9888
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000005672
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611101,228,894 - 101,229,394 (+)MPROMDB
RGD ID:8676794
Promoter ID:EPDNEW_M16427
Type:multiple initiation site
Name:G6pc_1
Description:Mus musculus glucose-6-phosphatase, catalytic , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811101,367,716 - 101,367,776EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95607 AgrOrtholog
Ensembl Genes ENSMUSG00000019325
  ENSMUSG00000078650 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000019469 ENTREZGENE
  ENSMUST00000019469.3 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphatidic acid phosphatase type 2/haloperoxidase UniProtKB/Swiss-Prot
InterPro Glucose-6-phosphatase UniProtKB/Swiss-Prot
  P_Acid_Pase_2/haloperoxi_sf UniProtKB/Swiss-Prot
  P_Acid_Pase_2/haloperoxidase UniProtKB/Swiss-Prot
KEGG Report mmu:14377 UniProtKB/Swiss-Prot
MGD MGI:95607 ENTREZGENE
NCBI Gene 14377 ENTREZGENE
PANTHER GLUCOSE-6-PHOSPHATASE UniProtKB/Swiss-Prot
  GLUCOSE-6-PHOSPHATASE CATALYTIC SUBUNIT 1 UniProtKB/Swiss-Prot
Pfam PAP2 UniProtKB/Swiss-Prot
PhenoGen G6pc1 PhenoGen
PIRSF Glucose-6-phosphatase UniProtKB/Swiss-Prot
SMART acidPPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48317 UniProtKB/Swiss-Prot
UniProt G6PC_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q91WV3 ENTREZGENE
UniProt Secondary Q91WV3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-06-05 G6pc1  glucose-6-phosphatase catalytic subunit 1  G6pc  glucose-6-phosphatase, catalytic  Symbol and/or name updated 27372883 PROVISIONAL