Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: G6PC (glucose-6-phosphatase catalytic subunit) Homo sapiens
Symbol: G6PC
Name: glucose-6-phosphatase catalytic subunit
Description: Exhibits glucose-6-phosphatase activity and phosphate ion binding activity. Involved in gluconeogenesis and glucose homeostasis. Localizes to integral component of membrane. Implicated in hepatocellular carcinoma. Biomarker of type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: G-6-Pase; G6Pase; G6Pase-alpha; G6PC1; G6PT; glucose-6-phosphatase; glucose-6-phosphatase alpha; glucose-6-phosphatase, catalytic subunit; GSD1; GSD1a; MGC163350
Mus musculus (house mouse) : G6pc (glucose-6-phosphatase, catalytic)  MGI  Alliance
Rattus norvegicus (Norway rat) : G6pc (glucose-6-phosphatase, catalytic subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : G6pc (glucose-6-phosphatase catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : G6PC (glucose-6-phosphatase catalytic subunit)
Canis lupus familiaris (dog) : G6PC (glucose-6-phosphatase catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : G6pc (glucose-6-phosphatase catalytic subunit)
Sus scrofa (pig) : G6PC (glucose-6-phosphatase catalytic subunit)
Chlorocebus sabaeus (African green monkey) : G6PC (glucose-6-phosphatase catalytic subunit)
Heterocephalus glaber (naked mole-rat) : G6pc (glucose-6-phosphatase catalytic subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1742,900,797 - 42,914,438 (+)EnsemblGRCh38hg38GRCh38
GRCh381742,900,799 - 42,914,438 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371741,052,814 - 41,066,450 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,306,341 - 38,318,912 (+)NCBINCBI36hg18NCBI36
Build 341738,306,340 - 38,318,912NCBI
Celera1737,708,948 - 37,721,525 (+)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1736,817,624 - 36,831,212 (+)NCBIHuRef
CHM1_11741,288,425 - 41,302,053 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on G6PC
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736011
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.