RGD Reference Report - Positive association between STAT3 and Ki-67 in cervical intraepithelial neoplasia. - Rat Genome Database

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Positive association between STAT3 and Ki-67 in cervical intraepithelial neoplasia.

Authors: Yang, SF  Yuan, SS  Yeh, YT  Hung, SC  Wu, MT  Su, JH  Chai, CY 
Citation: Yang SF, etal., Kaohsiung J Med Sci. 2006 Nov;22(11):539-46.
RGD ID: 2291916
Pubmed: PMID:17110342   (View Abstract at PubMed)
DOI: DOI:10.1016/S1607-551X(09)70350-X   (Journal Full-text)

Signal transducer and activator of transcription 3 (STAT3) has been regarded as an oncogene in many types of cancers. However, its role in cervical carcinogenesis is not well determined. The purpose of this study was to evaluate the expression patterns of STAT3 in cervical intraepithelial neoplasia (CIN), normal cervix (NC), and squamous cell carcinoma (SCC) to explore its possible role in cervical carcinogenesis. Paraffin-embedded sections from 83 patients including 20 CIN 1, 10 CIN 2, 26 CIN 3, and 27 comparative cases of 10 NC and 17 stage Ib SCC were collected in this study. Immunohistochemistry was performed to analyze the expression patterns of STAT3, and the results obtained were categorized by a semiquantitative method and were further correlated with the CIN histopathologic grade and the proliferation marker, Ki-67, using the chi2 test. Our results showed that nuclear STAT3 expression was predominantly in the squamous epithelial cells, and that high-grade CIN and stage Ib SCC lesions had a higher nuclear STAT3 expression when compared with NC and CIN 1. Furthermore, the nuclear STAT3 expression in CIN was significantly correlated with Ki-67 expression (p = 0.025), but not CIN lesion grade. In summary, our results indicate that an altered STAT3 expression in CIN is correlated with cell proliferation but may not have a direct contribution to cervical carcinogenesis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
STAT3Humancervix uteri carcinoma in situ  IEP protein:increased expression:nucleusRGD 
Stat3Ratcervix uteri carcinoma in situ  ISOSTAT3 (Homo sapiens)protein:increased expression:nucleusRGD 
Stat3Mousecervix uteri carcinoma in situ  ISOSTAT3 (Homo sapiens)protein:increased expression:nucleusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Stat3  (signal transducer and activator of transcription 3)

Genes (Mus musculus)
Stat3  (signal transducer and activator of transcription 3)

Genes (Homo sapiens)
STAT3  (signal transducer and activator of transcription 3)


Additional Information