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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3affects methylationISOSTAT3 (Homo sapiens)6480464CTDArsenic affects the methylation of STAT3 genePMID:25304211
Stat3affects phosphorylationISOStat3 (Mus musculus)6480464CTDArsenic affects the phosphorylation of STAT3 proteinPMID:27289040
Stat3affects phosphorylationISOSTAT3 (Homo sapiens)6480464CTDArsenic affects the phosphorylation of STAT3 proteinPMID:35031324
Stat3decreases expressionISOSTAT3 (Homo sapiens)6480464CTDArsenic results in decreased expression of STAT3 mRNAPMID:35031324
Stat3decreases response to substanceISOSTAT3 (Homo sapiens)6480464CTDSTAT3 results in decreased susceptibility to ArsenicPMID:15116095
Stat3increases expressionISOSTAT3 (Homo sapiens)6480464CTDArsenic results in increased expression of STAT3 mRNAPMID:27838757
Stat3increases phosphorylationISOSTAT3 (Homo sapiens)6480464CTDArsenic analog results in increased phosphorylation of STAT3 protein; Arsenic results in increased phosphorylation of STAT3 proteinPMID:24582688 PMID:25559853
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTD[ATF3 protein affects the susceptibility to Arsenic] which affects the phosphorylation of STAT3 protein; [sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of STAT3 protein; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of STAT3 protein]; CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of STAT3 protein]; Genistein inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of STAT3 protein]; Lapatinib inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of STAT3 protein]]; reparixin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [Arsenic results in increased expression of VEGFA protein]PMID:24582688 PMID:25559853 PMID:33396024 PMID:34364923
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