RGD Reference Report - Increased production of IL-5 and dominant Th2-type response in airways of Churg-Strauss syndrome patients. - Rat Genome Database

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Increased production of IL-5 and dominant Th2-type response in airways of Churg-Strauss syndrome patients.

Authors: Jakiela, B  Szczeklik, W  Plutecka, H  Sokolowska, B  Mastalerz, L  Sanak, M  Bazan-Socha, S  Szczeklik, A  Musial, J 
Citation: Jakiela B, etal., Rheumatology (Oxford). 2012 Jul 5.
RGD ID: 6892720
Pubmed: PMID:22772323   (View Abstract at PubMed)
DOI: DOI:10.1093/rheumatology/kes171   (Journal Full-text)

Objective. Churg-Strauss syndrome (CSS) is a rare systemic vasculitis associated with eosinophilia and asthma. We assessed the local immune response in airways of CSS patients with different activity of the disease.Methods. Concentration of IL-5, CCL17, CCL22 and CCL26 (ELISA) together with cell expression of T-helper-related genes (real-time PCR array) were measured in bronchoalveolar lavage fluid (BALF) sampled from 11 patients with active CSS, 11 patients with CSS in remission and 9 control subjects with bronchial asthma.Results. In active CSS, both BALF and blood eosinophil counts were increased (P < 0.01). BALF cells in active disease were characterized by an increased expression of Th2 and regulatory-type transcripts: STAT6, STAT3, GATA3, IL4, IL5 and IL10 as compared with asthmatics, and STAT5A, CCR4, FOXP3, IL4, IL5 and IL10 when compared with inactive CSS. There was significant increase in BALF concentration of IL-5 and CCL26 in exacerbation of CSS. CCR4-active chemokines were detected more frequently in active disease. We found a strong positive correlation between clinical parameters of disease activity (BVAS, eosinophilia) and expression of IL4, IL5, IL10 and STAT5A.Conclusion. These results indicate that as compared with asthma, active-CSS patients have much stronger local Th2 response in the airways. Airway cells may contribute to lung eosinophilia in CSS by producing IL-5 and eosinophil active chemokines.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL5HumanChurg-Strauss syndrome severityIEP  RGD 
Il5RatChurg-Strauss syndrome severityISOIL5 (Homo sapiens) RGD 
Il5MouseChurg-Strauss syndrome severityISOIL5 (Homo sapiens) RGD 
STAT3HumanChurg-Strauss syndrome  IEP  RGD 
Stat3RatChurg-Strauss syndrome  ISOSTAT3 (Homo sapiens) RGD 
Stat3MouseChurg-Strauss syndrome  ISOSTAT3 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il5  (interleukin 5)
Stat3  (signal transducer and activator of transcription 3)

Genes (Mus musculus)
Il5  (interleukin 5)
Stat3  (signal transducer and activator of transcription 3)

Genes (Homo sapiens)
IL5  (interleukin 5)
STAT3  (signal transducer and activator of transcription 3)


Additional Information