IL5 (interleukin 5) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: IL5 (interleukin 5) Homo sapiens
Analyze
Symbol: IL5
Name: interleukin 5
RGD ID: 730927
HGNC Page HGNC:6016
Description: Enables cytokine activity. Involved in interleukin-5-mediated signaling pathway and positive regulation of podosome assembly. Located in extracellular region. Is active in extracellular space. Implicated in asthma and stomach cancer. Biomarker of several diseases, including Churg-Strauss syndrome; Henoch-Schoenlein purpura; arthritis (multiple); asthma (multiple); and lymphoid leukemia (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: B cell differentiation factor I; B-cell differentiation factor I; colony-stimulating factor, eosinophil; EDF; eosinophil differentiation factor; IL-5; interleukin-5; T-cell replacing factor; TRF
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,541,445 - 132,556,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,541,445 - 132,556,838 (-)EnsemblGRCh38hg38GRCh38
GRCh375131,877,137 - 131,879,214 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,905,035 - 131,907,113 (-)NCBINCBI36Build 36hg18NCBI36
Build 345131,905,034 - 131,907,113NCBI
Celera5128,007,258 - 128,009,336 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,069,401 - 127,071,479 (-)NCBIHuRef
CHM1_15131,310,410 - 131,312,488 (-)NCBICHM1_1
T2T-CHM13v2.05133,061,254 - 133,076,701 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adult T-cell leukemia/lymphoma  (IEP)
allergic contact dermatitis  (EXP)
allergic rhinitis  (ISO)
angiostrongyliasis  (ISO)
asthma  (EXP,IAGP,IDA,IEP,ISO)
atopic dermatitis  (EXP,IEP)
autistic disorder  (EXP)
autoimmune hepatitis  (EXP)
B-lymphoblastic leukemia/lymphoma  (ISO)
Brain Injuries  (ISO)
Bronchial Hyperreactivity  (ISO)
chronic lymphocytic leukemia  (IEP)
chronic obstructive pulmonary disease  (IEP)
Churg-Strauss syndrome  (IEP)
colitis  (ISO)
Coronavirus infectious disease  (ISO)
Cough  (IDA)
Cytomegalovirus Infections  (IEP)
echinococcosis  (ISO)
Entamoebiasis  (EXP)
Eosinophilia  (EXP,IAGP,IEP,ISO)
eosinophilic esophagitis  (ISO)
eosinophilic gastroenteritis  (IEP)
esophageal cancer  (ISO)
Experimental Autoimmune Neuritis  (ISO)
extrinsic allergic alveolitis  (ISO)
familial adenomatous polyposis 1  (IAGP)
food allergy  (IEP)
Henoch-Schoenlein purpura  (IEP)
Hereditary Neoplastic Syndromes  (IAGP)
inflammatory bowel disease  (ISO)
major depressive disorder  (IEP)
middle cerebral artery infarction  (ISO)
nephrotic syndrome  (IEP)
Neurodevelopmental Disorders  (IAGP)
osteoarthritis  (IEP)
Parasitic Intestinal Diseases  (IEP)
peptic esophagitis  (ISO)
Perennial Allergic Rhinitis  (IEP)
prostatic hypertrophy  (ISO)
pulmonary eosinophilia  (IEP,ISO)
pulmonary fibrosis  (EXP,ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (IEP)
rhinitis  (ISO)
sickle cell anemia  (ISO)
status asthmaticus  (IEP)
stomach cancer  (IAGP)
strongyloidiasis  (ISO)
systemic lupus erythematosus  (IEP)
Transplant Rejection  (ISO)
urinary schistosomiasis  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1,1-dichloroethene  (ISO)
1,2,3,7,8-Pentachlorodibenzodioxin  (ISO)
1,4-dithiothreitol  (EXP)
1-Aminopyrene  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
15-acetyldeoxynivalenol  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-acetyldeoxynivalenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
6-anilino-5,8-quinolinedione  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinoic acid  (EXP)
acetic acid  (ISO)
acetone  (EXP)
acetylcholine  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
albuterol  (EXP)
alclometasone dipropionate  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
all-trans-retinoic acid  (EXP)
alpha-galactosylceramide  (ISO)
aluminium hydroxide  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
aripiprazole  (EXP)
asbestos  (EXP,ISO)
atrazine  (EXP,ISO)
beclomethasone  (EXP,ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzofurans  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (ISO)
betamethasone valerate  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bucladesine  (EXP)
budesonide  (ISO)
cadmium dichloride  (EXP)
caffeine  (EXP)
Calcimycin  (EXP)
calcipotriol  (ISO)
cannabidiol  (EXP)
capsaicin  (ISO)
carbon nanotube  (EXP,ISO)
cetirizine  (EXP)
chloroform  (ISO)
cilostazol  (ISO)
clobenpropit  (EXP)
clozapine  (EXP)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cordycepin  (EXP)
cortisol  (EXP,ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cytochalasin B  (EXP)
deoxynivalenol  (ISO)
desloratadine  (EXP)
dexamethasone  (EXP,ISO)
diclofenac  (EXP)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
Dimaprit  (EXP)
dioscin  (ISO)
diuron  (EXP)
emamectin benzoate  (EXP)
emodin  (ISO)
epinastine  (EXP)
Erionite  (ISO)
ethene  (ISO)
fenvalerate  (ISO)
ferric oxide  (ISO)
fisetin  (EXP)
flavonoids  (ISO)
flucloxacillin  (ISO)
flutamide  (ISO)
fluticasone  (EXP)
formaldehyde  (ISO)
fragrance  (EXP)
furfuryl alcohol  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (ISO)
glyphosate  (ISO)
gossypin  (ISO)
hexachlorobenzene  (EXP)
hexamethylene diisocyanate  (ISO)
histamine  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
hydroxysafflor yellow A  (ISO)
hydroxytyrosol  (EXP)
IC-87114  (ISO)
ICI 118551  (EXP)
ionomycin  (EXP,ISO)
isosilybin A  (ISO)
itraconazole  (EXP)
kaempferol  (EXP)
ketoconazole  (EXP)
L-1,4-dithiothreitol  (EXP)
L-arginine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
leukotriene C4  (EXP)
leukotriene D4  (EXP)
linoleic acid  (EXP)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
luteolin  (ISO)
melatonin  (ISO)
mercury dichloride  (ISO)
methimazole  (ISO)
methoxychlor  (ISO)
miconazole  (EXP)
mifepristone  (ISO)
Monocyte locomotion inhibitory factor  (EXP)
montelukast  (EXP,ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
naproxen  (ISO)
nicardipine  (ISO)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
nitric oxide  (EXP)
nitroprusside  (ISO)
nitrososulfamethoxazole  (EXP)
Nivalenol  (ISO)
Nonylphenol  (ISO)
o-anisidine  (EXP)
ozone  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
permethrin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalaldehyde  (ISO)
phthalic anhydride  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
polymyxin B2  (ISO)
pomalidomide  (EXP)
prednisolone  (EXP,ISO)
prednisone  (EXP)
prostaglandin E2  (EXP)
Pyridostigmine bromide  (ISO)
quercetin  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
ribavirin  (EXP)
ruxolitinib  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-nitrosoglutathione  (EXP)
serpentine asbestos  (ISO)
sildenafil citrate  (ISO)
silicon dioxide  (ISO)
Silidianin  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (ISO)
sodium arsenite  (EXP)
sodium dichromate  (EXP)
solasodine  (ISO)
SR 144528  (EXP)
staurosporine  (EXP)
sulfadimethoxine  (ISO)
sulfamethoxazole  (ISO)
sumatriptan  (ISO)
superoxide  (EXP)
syringin  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
terbinafine  (EXP)
Terfenadine  (EXP)
tetrachloromethane  (ISO)
thiazoles  (EXP)
thimerosal  (EXP)
titanium dioxide  (EXP,ISO)
tolnaftate  (EXP)
toluene  (ISO)
toluene 2,4-diisocyanate  (ISO)
tremolite asbestos  (ISO)
triadimefon  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (EXP)
verrucarin A  (ISO)
vitamin E  (EXP,ISO)
wogonin  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. The sickle cell mouse lung: proinflammatory and primed for allergic inflammation. Andemariam B, etal., Transl Res. 2015 Sep;166(3):254-68. doi: 10.1016/j.trsl.2015.03.001. Epub 2015 Mar 16.
2. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. Chen J, etal., J Virol. 2010 Feb;84(3):1289-301. Epub 2009 Nov 11.
3. [Effect of Scoparone on Th1/Th2 cytokines and IgE in the experimental allergic rhinitis rats]. Cheng L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Dec;27(23):1310-2.
4. Interleukin-5 reduces the expression of uteroglobin-related protein (UGRP) 1 gene in allergic airway inflammation. Chiba Y, etal., Immunol Lett. 2005 Feb 15;97(1):123-9.
5. Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma. Cho SH, etal., Am J Respir Crit Care Med. 2005 Feb 1;171(3):224-30. Epub 2004 Oct 22.
6. A profile of immune response to herpesvirus is associated with radiographic damage in rheumatoid arthritis. Davis JM 3rd, etal., Arthritis Res Ther. 2012 Jan 31;14(1):R24.
7. Interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 in eosinophilic gastroenteritis. Desreumaux P, etal., Gastroenterology. 1996 Mar;110(3):768-74.
8. Elevated levels of serum IL-5 are associated with an increased likelihood of major depressive disorder. Elomaa AP, etal., BMC Psychiatry. 2012 Jan 9;12:2.
9. Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosis. Emad A and Emad Y, J Clin Immunol. 2008 Jul;28(4):298-305. Epub 2007 Jun 28.
10. Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis. Engel MA, etal., Dig Liver Dis. 2012 Jan;44(1):24-9. Epub 2011 Oct 22.
11. Cytokine gene expression in the skin and peripheral blood of atopic dermatitis patients and healthy individuals. Fedenko ES, etal., Self Nonself. 2011 Apr;2(2):120-124. Epub 2011 Apr 1.
12. Association of polymorphisms in the human IL4 and IL5 genes with atopic bronchial asthma and severity of the disease. Freidin MB, etal., Comp Funct Genomics. 2003;4(3):346-50.
13. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. Fuss IJ, etal., J Immunol. 1996 Aug 1;157(3):1261-70.
14. Chronic cough resembles asthma with IL-5 and granulocyte-macrophage colony-stimulating factor gene expression in bronchoalveolar cells. Gibson PG, etal., J Allergy Clin Immunol. 1998 Mar;101(3):320-6.
15. Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic mice. Glaab T, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Mar;280(3):L565-73.
16. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
17. An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsiveness. Hall LR, etal., Infect Immun. 1998 Sep;66(9):4425-30.
18. Anti-interleukin 5 but not anti-IgE prevents airway inflammation and airway hyperresponsiveness. Hamelmann E, etal., Am J Respir Crit Care Med. 1999 Sep;160(3):934-41.
19. IL-5 prolongs allograft survival by downregulating IL-2 and IFN-gamma cytokines. He XY, etal., Transplant Proc. 2001 Feb-Mar;33(1-2):703-4.
20. IL-5 and thromboxane A2 receptor gene polymorphisms are associated with decreased pulmonary function in Korean children with atopic asthma. Hong SJ, etal., J Allergy Clin Immunol. 2005 Apr;115(4):758-63.
21. Clinical significance of serum Th1-, Th2- and regulatory T cells-associated cytokines in adult T-cell leukemia/lymphoma: high interleukin-5 and -10 levels are significant unfavorable prognostic factors. Inagaki A, etal., Int J Cancer. 2006 Jun 15;118(12):3054-61.
22. Increased production of IL-5 and dominant Th2-type response in airways of Churg-Strauss syndrome patients. Jakiela B, etal., Rheumatology (Oxford). 2012 Jul 5.
23. Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein. Johnson TR, etal., J Leukoc Biol. 2008 Sep;84(3):748-59. Epub 2008 Jun 2.
24. Interleukin-17-mediated immunopathogenesis in experimental hypersensitivity pneumonitis. Joshi AD, etal., Am J Respir Crit Care Med. 2009 Apr 15;179(8):705-16. Epub 2009 Jan 16.
25. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. Lee JJ, etal., J Exp Med. 1997 Jun 16;185(12):2143-56.
26. Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma. Lee MY, etal., Int Immunopharmacol. 2012 Jan;12(1):117-24. Epub 2011 Nov 12.
27. [Serum levels of IL-5 and LTB4 in children with Henoch-Schonlein purpura]. Liao PY and Wu SH, Zhongguo Dang Dai Er Ke Za Zhi. 2006 Jun;8(3):198-200.
28. [The roles of interleukin-5 and eotaxin in signal transmission between lung and bone marrow of rat asthmatic models] Liu CT, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Aug;29(8):558-62.
29. [Effects of suplatast tosilate on airway inflammation and interleukin-5 in asthmatic rats]. Liu D, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2014 Jul;16(7):759-63.
30. Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population. Mahajan R, etal., Jpn J Clin Oncol. 2008 Sep;38(9):626-33. doi: 10.1093/jjco/hyn075. Epub 2008 Aug 7.
31. Spirometric parameters and levels of interferon gamma and IL-5 in induced sputum from patients with allergic rhinitis or asthma. Marra SM, etal., Am J Rhinol Allergy. 2011 Sep-Oct;25(5):e196-9.
32. T-cell activation genes differentially expressed at birth in CD4(+) T-cells from children who develop IgE food allergy. Martino DJ, etal., Allergy. 2012 Feb;67(2):191-200. doi: 10.1111/j.1398-9995.2011.02737.x. Epub 2011 Nov 11.
33. Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis. Masterson JC, etal., Gut. 2014 Jan;63(1):43-53. doi: 10.1136/gutjnl-2012-303631. Epub 2012 Nov 17.
34. Increased interleukin-4 and interleukin-5 production in response to Schistosoma haematobium adult worm antigens correlates with lack of reinfection after treatment. Medhat A, etal., J Infect Dis. 1998 Aug;178(2):512-9.
35. Early peritoneal immune response during Echinococcus granulosus establishment displays a biphasic behavior. Mourglia-Ettlin G, etal., PLoS Negl Trop Dis. 2011 Aug;5(8):e1293. doi: 10.1371/journal.pntd.0001293. Epub 2011 Aug 30.
36. Increased vascular endothelial growth factor in acute eosinophilic pneumonia. Nishigaki Y, etal., Eur Respir J. 2003 May;21(5):774-8.
37. [An investigation of the clinical utility of serum interleukin-5 measurements in bronchial asthma patients]. Onizuka R, etal., Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Nov;35(11):1215-22.
38. Regulation of primary Strongyloides ratti infections in mice: a role for interleukin-5. Ovington KS, etal., Immunology. 1998 Nov;95(3):488-93.
39. Expression profiles of Th17 pathway related genes in human systemic lupus erythematosus. Pan HF, etal., Mol Biol Rep. 2013 Jan;40(1):391-9. doi: 10.1007/s11033-012-2073-2. Epub 2012 Oct 9.
40. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
41. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
42. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. LHRH antagonist Cetrorelix reduces prostate size and gene expression of proinflammatory cytokines and growth factors in a rat model of benign prostatic hyperplasia. Rick FG, etal., Prostate. 2011 May 15;71(7):736-47. doi: 10.1002/pros.21289. Epub 2010 Oct 13.
45. Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke. Ruscher K, etal., PLoS One. 2012;7(9):e45118. doi: 10.1371/journal.pone.0045118. Epub 2012 Sep 18.
46. Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiency. Saito H, etal., J Immunol. 2002 Mar 15;168(6):3017-23.
47. Ablation of eosinophils with anti-IL-5 antibody enhances the survival of intracranial worms of Angiostrongylus cantonensis in the mouse. Sasaki O, etal., Parasite Immunol. 1993 Jun;15(6):349-54.
48. Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats. Stoner GD, etal., Pharm Res. 2010 Jun;27(6):1138-45. Epub 2010 Mar 16.
49. Taurine improves functional and histological outcomes and reduces inflammation in traumatic brain injury. Su Y, etal., Neuroscience. 2014 Apr 25;266:56-65. doi: 10.1016/j.neuroscience.2014.02.006. Epub 2014 Feb 14.
50. Dual proinflammatory and antiviral properties of pulmonary eosinophils in respiratory syncytial virus vaccine-enhanced disease. Su YC, etal., J Virol. 2015 Feb;89(3):1564-78. doi: 10.1128/JVI.01536-14. Epub 2014 Nov 19.
51. A novel rat model to determine interaction between reflux oesophagitis and bronchial asthma. Sugawa T, etal., Gut. 2008 May;57(5):575-81. Epub 2008 Jan 25.
52. Preventive effect of hochu-ekki-to, a Japanese herbal medicine, on bleomycin-induced lung injury in mice. Tajima S, etal., Respirology. 2007 Nov;12(6):814-22.
53. Suppressed cytokine expression immediatey following traumatic brain injury in neonatal rats indicates an expeditious endogenous anti-inflammatory response. Tajiri N, etal., Brain Res. 2014 Apr 22;1559:65-71. doi: 10.1016/j.brainres.2014.02.041. Epub 2014 Mar 3.
54. Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice. Tanaka H, etal., Am J Respir Cell Mol Biol. 2004 Jul;31(1):62-8. Epub 2004 Feb 19.
55. TARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas. Thielen C, etal., Leuk Res. 2008 Sep;32(9):1431-8. doi: 10.1016/j.leukres.2008.02.016. Epub 2008 Apr 18.
56. CC chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus. Potential implication in eosinophil recruitment. Tillie-Leblond I, etal., Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):586-92.
57. Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production. Tominaga A, etal., J Exp Med. 1991 Feb 1;173(2):429-37.
58. IL-5 promotes induction of antigen-specific CD4+CD25+ T regulatory cells that suppress autoimmunity. Tran GT, etal., Blood. 2012 May 10;119(19):4441-50. doi: 10.1182/blood-2011-12-396101. Epub 2012 Feb 6.
59. The differences of eosinophil- and neutrophil-related inflammation in elderly allergic and non-allergic chronic obstructive pulmonary disease. Tsai JJ, etal., J Asthma. 2010 Nov;47(9):1040-4.
60. Interleukin (IL) 5 levels and eosinophilia in patients with intestinal parasitic diseases. Ustun S, etal., World J Gastroenterol. 2004 Dec 15;10(24):3643-6.
61. Human knee synovial fluid cytokines correlated with grade of knee osteoarthritis--a pilot study. Vangsness CT Jr, etal., Bull NYU Hosp Jt Dis. 2011;69(2):122-7.
62. Knockdown of neurokinin-1 receptor expression by small interfering RNA prevents the development of allergic rhinitis in rats. Wang H, etal., Inflamm Res. 2013 Oct;62(10):903-10. doi: 10.1007/s00011-013-0649-5. Epub 2013 Aug 11.
63. Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus. Wen X, etal., Eur J Immunol. 2004 Oct;34(10):2740-9.
64. In vivo changes of hemopoietic progenitors and the expression of the interleukin 5 gene in eosinophilic mice infected with Toxocara canis. Yamaguchi Y, etal., Exp Hematol. 1990 Dec;18(11):1152-7.
65. Heterogeneity of interleukin 5 genetic background in atopic dermatitis patients: significant difference between those with blood eosinophilia and normal eosinophil levels. Yamamoto N, etal., J Dermatol Sci. 2003 Nov;33(2):121-6.
66. Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia. Yan XJ, etal., Blood. 2011 Nov 10;118(19):5201-10. doi: 10.1182/blood-2011-03-342436. Epub 2011 Sep 12.
67. The clinical characteristics of steroid responsive nephrotic syndrome of children according to the serum immunoglobulin E levels and cytokines. Youn YS, etal., Yonsei Med J. 2012 Jul 1;53(4):715-22. doi: 10.3349/ymj.2012.53.4.715.
68. Effects of antisense interleukin-5 gene transferred by recombinant adeno-associated virus to allergic rats. Zeng D, etal., Respirology. 2010 Jan;15(1):132-40. Epub 2009 Nov 30.
Additional References at PubMed
PMID:1495999   PMID:1698795   PMID:1732409   PMID:1833065   PMID:2037074   PMID:2361960   PMID:2563351   PMID:2823259   PMID:2824500   PMID:3024129   PMID:3498940   PMID:7534492  
PMID:7721873   PMID:7957082   PMID:8419187   PMID:8438156   PMID:8483502   PMID:8892648   PMID:9136909   PMID:10417272   PMID:10477722   PMID:10753117   PMID:10823900   PMID:10880230  
PMID:10973484   PMID:11101310   PMID:11763346   PMID:11830476   PMID:11842300   PMID:11877300   PMID:11897983   PMID:12097386   PMID:12202242   PMID:12354764   PMID:12366695   PMID:12393708  
PMID:12444155   PMID:12477932   PMID:12525574   PMID:12534990   PMID:12575459   PMID:12581193   PMID:12759409   PMID:12771545   PMID:12851716   PMID:12910312   PMID:12915771   PMID:14564341  
PMID:14630612   PMID:14634065   PMID:15007355   PMID:15155645   PMID:15220135   PMID:15271374   PMID:15367434   PMID:15489334   PMID:15528381   PMID:15549733   PMID:15563083   PMID:15713213  
PMID:15735688   PMID:15802551   PMID:15826943   PMID:15826950   PMID:15835818   PMID:15842590   PMID:15845862   PMID:15935984   PMID:15951665   PMID:15964392   PMID:16001979   PMID:16036415  
PMID:16236836   PMID:16243713   PMID:16449530   PMID:16556602   PMID:16596275   PMID:16722389   PMID:16879311   PMID:16922677   PMID:16929824   PMID:17015735   PMID:17362254   PMID:17438848  
PMID:17517104   PMID:17567994   PMID:17581195   PMID:17620002   PMID:17620072   PMID:17623648   PMID:17628972   PMID:17690326   PMID:17703412   PMID:17845581   PMID:18028994   PMID:18056382  
PMID:18206982   PMID:18273035   PMID:18383036   PMID:18519231   PMID:18633131   PMID:18676870   PMID:18686101   PMID:18712166   PMID:18772129   PMID:18818748   PMID:18844613   PMID:18849614  
PMID:18925696   PMID:18996999   PMID:19019335   PMID:19050632   PMID:19131452   PMID:19141349   PMID:19152965   PMID:19168731   PMID:19180571   PMID:19198610   PMID:19200845   PMID:19222422  
PMID:19247692   PMID:19258923   PMID:19299749   PMID:19336370   PMID:19360850   PMID:19379606   PMID:19419945   PMID:19478474   PMID:19486544   PMID:19527514   PMID:19533685   PMID:19573080  
PMID:19578876   PMID:19698128   PMID:19773279   PMID:19773451   PMID:19840389   PMID:19845895   PMID:19860791   PMID:19913121   PMID:19914334   PMID:20041150   PMID:20237496   PMID:20332709  
PMID:20403914   PMID:20418110   PMID:20452482   PMID:20453000   PMID:20503287   PMID:20523065   PMID:20530519   PMID:20561085   PMID:20568250   PMID:20628086   PMID:20636896   PMID:20650294  
PMID:20673868   PMID:20825427   PMID:20943047   PMID:20952689   PMID:21168500   PMID:21235536   PMID:21323726   PMID:21418620   PMID:21609545   PMID:21849680   PMID:21986312   PMID:22092535  
PMID:22153509   PMID:22528658   PMID:22541618   PMID:22710862   PMID:22805115   PMID:22962576   PMID:23128233   PMID:23306429   PMID:23306834   PMID:23328843   PMID:23382558   PMID:23401558  
PMID:23555579   PMID:23684072   PMID:23770289   PMID:23957336   PMID:24447082   PMID:24530098   PMID:24706315   PMID:24710117   PMID:24738292   PMID:24822215   PMID:24875149   PMID:24980230  
PMID:25121926   PMID:25585038   PMID:25587992   PMID:25613757   PMID:25703059   PMID:25817862   PMID:25840634   PMID:25937050   PMID:26282695   PMID:26821299   PMID:26859368   PMID:27060452  
PMID:27275740   PMID:28226398   PMID:28398462   PMID:28737771   PMID:28752719   PMID:28915273   PMID:29247803   PMID:29602685   PMID:29921484   PMID:30072087   PMID:30210646   PMID:30529748  
PMID:30694585   PMID:30974106   PMID:31175163   PMID:31333650   PMID:31495774   PMID:31673233   PMID:31830482   PMID:31900992   PMID:32447242   PMID:32552827   PMID:33003107   PMID:33099778  
PMID:33109625   PMID:33176218   PMID:33191121   PMID:33494375   PMID:33852849   PMID:33921360   PMID:34239620   PMID:35243803   PMID:35752781   PMID:36233301   PMID:36543402   PMID:36685563  
PMID:37301436   PMID:37705107   PMID:37759746   PMID:37908348   PMID:38497343   PMID:38612591  


Genomics

Comparative Map Data
IL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,541,445 - 132,556,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,541,445 - 132,556,838 (-)EnsemblGRCh38hg38GRCh38
GRCh375131,877,137 - 131,879,214 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,905,035 - 131,907,113 (-)NCBINCBI36Build 36hg18NCBI36
Build 345131,905,034 - 131,907,113NCBI
Celera5128,007,258 - 128,009,336 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,069,401 - 127,071,479 (-)NCBIHuRef
CHM1_15131,310,410 - 131,312,488 (-)NCBICHM1_1
T2T-CHM13v2.05133,061,254 - 133,076,701 (-)NCBIT2T-CHM13v2.0
Il5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,611,621 - 53,615,930 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,611,621 - 53,615,933 (+)EnsemblGRCm39 Ensembl
GRCm381153,720,794 - 53,725,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,720,794 - 53,725,106 (+)EnsemblGRCm38mm10GRCm38
MGSCv371153,534,296 - 53,538,605 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361153,564,217 - 53,568,526 (+)NCBIMGSCv36mm8
Celera1158,300,334 - 58,304,644 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.99NCBI
Il5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,375,132 - 38,378,003 (+)NCBIGRCr8
mRatBN7.21037,874,342 - 37,877,213 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,874,342 - 37,877,213 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1042,566,241 - 42,569,117 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,056,311 - 42,059,187 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,560,033 - 37,562,909 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,066,716 - 39,069,587 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,066,716 - 39,069,587 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01038,848,654 - 38,851,525 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,177,786 - 39,180,657 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,187,032 - 39,189,904 (+)NCBI
Celera1037,217,913 - 37,220,782 (+)NCBICelera
RH 3.4 Map10405.8RGD
Cytogenetic Map10q22NCBI
Il5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554083,937,894 - 3,939,358 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554083,937,128 - 3,951,784 (-)NCBIChiLan1.0ChiLan1.0
IL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,852,984 - 127,868,373 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15125,985,380 - 126,007,938 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,955,377 - 127,961,726 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,119,608 - 134,121,682 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,119,608 - 134,121,675 (-)Ensemblpanpan1.1panPan2
IL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,825,469 - 20,827,269 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,825,469 - 20,827,269 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,627,141 - 19,628,942 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01121,611,416 - 21,613,216 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,611,416 - 21,613,216 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,329,893 - 20,331,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,177,516 - 20,179,316 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,819,966 - 20,821,765 (-)NCBIUU_Cfam_GSD_1.0
Il5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,645,479 - 115,648,668 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,648,241 - 2,651,430 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,647,982 - 2,651,477 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,832,147 - 134,835,212 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12134,832,143 - 134,846,141 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,301,702 - 140,315,329 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,360,143 - 35,375,169 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,360,506 - 35,362,178 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603442,568,292 - 42,583,307 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,556,797 - 39,559,119 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473339,544,487 - 39,558,943 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IL5
10 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q23.2-31.1(chr5:126438406-132873967)x1 copy number loss See cases [RCV000052109] Chr5:126438406..132873967 [GRCh38]
Chr5:125774098..132209659 [GRCh37]
Chr5:125801997..132237558 [NCBI36]
Chr5:5q23.2-31.1
pathogenic
GRCh38/hg38 5q31.1(chr5:132301874-134187817)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053312]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053312]|See cases [RCV000053312] Chr5:132301874..134187817 [GRCh38]
Chr5:131637567..133523508 [GRCh37]
Chr5:131665466..133551407 [NCBI36]
Chr5:5q31.1
uncertain significance
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
GRCh38/hg38 5q23.1-31.1(chr5:116677122-132686163)x1 copy number loss See cases [RCV000053525] Chr5:116677122..132686163 [GRCh38]
Chr5:116012818..132021855 [GRCh37]
Chr5:116040717..132049754 [NCBI36]
Chr5:5q23.1-31.1
pathogenic
GRCh38/hg38 5q31.1(chr5:131626503-135815054)x1 copy number loss See cases [RCV000135442] Chr5:131626503..135815054 [GRCh38]
Chr5:130962196..135150743 [GRCh37]
Chr5:130990095..135178642 [NCBI36]
Chr5:5q31.1
pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV004561496]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q31.1(chr5:131484039-132998360)x3 copy number gain Blepharophimosis [RCV000677199] Chr5:131484039..132998360 [GRCh37]
Chr5:5q31.1
uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q23.2-31.2(chr5:126377719-136270989)x1 copy number loss not provided [RCV000762739] Chr5:126377719..136270989 [GRCh37]
Chr5:5q23.2-31.2
likely pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
NM_000879.3(IL5):c.384C>A (p.Thr128=) single nucleotide variant not provided [RCV000948300] Chr5:132541832 [GRCh38]
Chr5:131877524 [GRCh37]
Chr5:5q31.1
benign
NM_000879.3(IL5):c.312G>A (p.Lys104=) single nucleotide variant not provided [RCV000888984] Chr5:132541904 [GRCh38]
Chr5:131877596 [GRCh37]
Chr5:5q31.1
benign
NM_000879.3(IL5):c.108G>T (p.Leu36=) single nucleotide variant not provided [RCV000890701] Chr5:132543371 [GRCh38]
Chr5:131879063 [GRCh37]
Chr5:5q31.1
benign
NC_000005.10:g.132556665C>T single nucleotide variant not provided [RCV001709000] Chr5:132556665 [GRCh38]
Chr5:131892357 [GRCh37]
Chr5:5q31.1
benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5q23.3-31.1(chr5:127800418-134002686) copy number loss Houge-Janssens syndrome 3 [RCV003236718] Chr5:127800418..134002686 [GRCh37]
Chr5:5q23.3-31.1
pathogenic
NM_000879.3(IL5):c.146C>T (p.Thr49Ile) single nucleotide variant not specified [RCV004151495] Chr5:132543125 [GRCh38]
Chr5:131878817 [GRCh37]
Chr5:5q31.1
uncertain significance
NM_000879.3(IL5):c.312G>C (p.Lys104Asn) single nucleotide variant not specified [RCV004263968] Chr5:132541904 [GRCh38]
Chr5:131877596 [GRCh37]
Chr5:5q31.1
uncertain significance
GRCh37/hg19 5q23.2-31.1(chr5:124864529-134720575)x1 copy number loss not provided [RCV004577463] Chr5:124864529..134720575 [GRCh37]
Chr5:5q23.2-31.1
pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:255
Count of miRNA genes:179
Interacting mature miRNAs:184
Transcripts:ENST00000231454, ENST00000450655, ENST00000462418
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
407150032GWAS799008_Hasthma QTL GWAS799008 (human)1e-19asthma5132549548132549549Human
407210832GWAS859808_Hasthma QTL GWAS859808 (human)2e-15asthma5132552294132552295Human
407250945GWAS899921_Heosinophil count QTL GWAS899921 (human)8e-148eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)5132552294132552295Human
407039034GWAS688010_Hage of onset of childhood onset asthma QTL GWAS688010 (human)3e-33age of onset of childhood onset asthma5132549244132549245Human
407142589GWAS791565_Heosinophil count QTL GWAS791565 (human)9e-19eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)5132549202132549203Human
407149021GWAS797997_Hrosacea severity measurement QTL GWAS797997 (human)5e-08rosacea severity measurement5132549202132549203Human
407236767GWAS885743_Heosinophil count QTL GWAS885743 (human)2e-16eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)5132552977132552978Human
407304028GWAS953004_Hasthma QTL GWAS953004 (human)0.0000006asthma5132544224132544225Human
407341003GWAS989979_Heosinophil count QTL GWAS989979 (human)2e-159eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)5132554779132554780Human
407272923GWAS921899_Hasthma QTL GWAS921899 (human)5e-10asthma5132552294132552295Human

Markers in Region
GDB:181589  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,878,647 - 131,878,911UniSTSGRCh37
Build 365131,906,546 - 131,906,810RGDNCBI36
Celera5128,008,769 - 128,009,033RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,070,912 - 127,071,176UniSTS
PMC199428P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,877,519 - 131,877,798UniSTSGRCh37
Build 365131,905,418 - 131,905,697RGDNCBI36
Celera5128,007,641 - 128,007,920RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,069,784 - 127,070,063UniSTS
ECD01085  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,876,959 - 131,877,837UniSTSGRCh37
Build 365131,904,858 - 131,905,736RGDNCBI36
Celera5128,007,081 - 128,007,959RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,069,224 - 127,070,102UniSTS
ECD01086  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,880,124 - 131,881,002UniSTSGRCh37
Build 365131,908,023 - 131,908,901RGDNCBI36
Celera5128,010,246 - 128,011,124RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,072,389 - 127,073,267UniSTS
ECD08693  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,878,657 - 131,879,305UniSTSGRCh37
Build 365131,906,556 - 131,907,204RGDNCBI36
Celera5128,008,779 - 128,009,427RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,070,922 - 127,071,570UniSTS
ECD14018  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,877,997 - 131,878,500UniSTSGRCh37
Build 365131,905,896 - 131,906,399RGDNCBI36
Celera5128,008,119 - 128,008,622RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,070,262 - 127,070,765UniSTS
ECD21131  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,879,435 - 131,879,695UniSTSGRCh37
Build 365131,907,334 - 131,907,594RGDNCBI36
Celera5128,009,557 - 128,009,817RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,071,700 - 127,071,960UniSTS
REN70668  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,876,840 - 131,877,100UniSTSGRCh37
Build 365131,904,739 - 131,904,999RGDNCBI36
Celera5128,006,962 - 128,007,222RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,069,105 - 127,069,365UniSTS
REN70669  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,877,089 - 131,877,359UniSTSGRCh37
Build 365131,904,988 - 131,905,258RGDNCBI36
Celera5128,007,211 - 128,007,481RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,069,354 - 127,069,624UniSTS
REN70670  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,877,352 - 131,877,596UniSTSGRCh37
Build 365131,905,251 - 131,905,495RGDNCBI36
Celera5128,007,474 - 128,007,718RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,069,617 - 127,069,861UniSTS
REN70671  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,877,572 - 131,877,816UniSTSGRCh37
Build 365131,905,471 - 131,905,715RGDNCBI36
Celera5128,007,694 - 128,007,938RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,069,837 - 127,070,081UniSTS
REN70672  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,877,810 - 131,878,058UniSTSGRCh37
Build 365131,905,709 - 131,905,957RGDNCBI36
Celera5128,007,932 - 128,008,180RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,070,075 - 127,070,323UniSTS
REN70673  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,878,035 - 131,878,259UniSTSGRCh37
Build 365131,905,934 - 131,906,158RGDNCBI36
Celera5128,008,157 - 128,008,381RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,070,300 - 127,070,524UniSTS
REN70674  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,878,227 - 131,878,497UniSTSGRCh37
Build 365131,906,126 - 131,906,396RGDNCBI36
Celera5128,008,349 - 128,008,619RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,070,492 - 127,070,762UniSTS
REN70675  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,878,474 - 131,878,728UniSTSGRCh37
Build 365131,906,373 - 131,906,627RGDNCBI36
Celera5128,008,596 - 128,008,850RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,070,739 - 127,070,993UniSTS
REN70676  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,878,700 - 131,878,925UniSTSGRCh37
Build 365131,906,599 - 131,906,824RGDNCBI36
Celera5128,008,822 - 128,009,047RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,070,965 - 127,071,190UniSTS
REN70677  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,878,904 - 131,879,155UniSTSGRCh37
Build 365131,906,803 - 131,907,054RGDNCBI36
Celera5128,009,026 - 128,009,277RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,071,169 - 127,071,420UniSTS
REN70678  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,879,117 - 131,879,347UniSTSGRCh37
Build 365131,907,016 - 131,907,246RGDNCBI36
Celera5128,009,239 - 128,009,469RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,071,382 - 127,071,612UniSTS
REN70679  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,879,319 - 131,879,543UniSTSGRCh37
Build 365131,907,218 - 131,907,442RGDNCBI36
Celera5128,009,441 - 128,009,665RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,071,584 - 127,071,808UniSTS
REN70680  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,879,485 - 131,879,743UniSTSGRCh37
Build 365131,907,384 - 131,907,642RGDNCBI36
Celera5128,009,607 - 128,009,865RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,071,750 - 127,072,008UniSTS
REN70681  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,879,720 - 131,879,976UniSTSGRCh37
Build 365131,907,619 - 131,907,875RGDNCBI36
Celera5128,009,842 - 128,010,098RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,071,985 - 127,072,241UniSTS
REN70682  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,879,949 - 131,880,218UniSTSGRCh37
Build 365131,907,848 - 131,908,117RGDNCBI36
Celera5128,010,071 - 128,010,340RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,072,214 - 127,072,483UniSTS
REN70683  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,880,195 - 131,880,453UniSTSGRCh37
Build 365131,908,094 - 131,908,352RGDNCBI36
Celera5128,010,317 - 128,010,575RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,072,460 - 127,072,718UniSTS
REN70684  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,880,439 - 131,880,691UniSTSGRCh37
Build 365131,908,338 - 131,908,590RGDNCBI36
Celera5128,010,561 - 128,010,813RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,072,704 - 127,072,956UniSTS
REN70685  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,880,671 - 131,880,921UniSTSGRCh37
Build 365131,908,570 - 131,908,820RGDNCBI36
Celera5128,010,793 - 128,011,043RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,072,936 - 127,073,186UniSTS
REN70686  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,880,817 - 131,881,070UniSTSGRCh37
Build 365131,908,716 - 131,908,969RGDNCBI36
Celera5128,010,939 - 128,011,192RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,073,082 - 127,073,335UniSTS
stSG601346  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,876,759 - 131,877,782UniSTSGRCh37
Build 365131,904,658 - 131,905,681RGDNCBI36
Celera5128,006,881 - 128,007,904RGD
HuRef5127,069,024 - 127,070,047UniSTS
stSG601347  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,877,763 - 131,879,077UniSTSGRCh37
Build 365131,905,662 - 131,906,976RGDNCBI36
Celera5128,007,885 - 128,009,199RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,070,028 - 127,071,342UniSTS
stSG601348  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,879,062 - 131,880,440UniSTSGRCh37
Build 365131,906,961 - 131,908,339RGDNCBI36
Celera5128,009,184 - 128,010,562RGD
HuRef5127,071,327 - 127,072,705UniSTS
IL5  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,877,517 - 131,877,569UniSTSGRCh37
Build 365131,905,416 - 131,905,468RGDNCBI36
Celera5128,007,639 - 128,007,691RGD
HuRef5127,069,782 - 127,069,834UniSTS
RH18076  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,877,342 - 131,877,500UniSTSGRCh37
Build 365131,905,241 - 131,905,399RGDNCBI36
Celera5128,007,464 - 128,007,622RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,069,607 - 127,069,765UniSTS
GeneMap99-GB4 RH Map5510.57UniSTS
D5S2473  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh375131,877,193 - 131,877,493UniSTSGRCh37
Build 365131,905,092 - 131,905,392RGDNCBI36
Celera5128,007,315 - 128,007,615RGD
Cytogenetic Map5q31.1UniSTS
HuRef5127,069,458 - 127,069,758UniSTS
GeneMap99-GB4 RH Map5508.46UniSTS
Whitehead-RH Map5422.8UniSTS
Whitehead-YAC Contig Map5 UniSTS
GeneMap99-G3 RH Map55063.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
785 1754 1717 1518 3054 1150 1497 2 340 682 242 989 4098 3708 21 2833 515 1407 1069 104

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_033019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005271988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054352521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC116366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF353265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ655971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ655974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC461680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X12705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X12706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000231454   ⟹   ENSP00000231454
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5132,541,445 - 132,543,522 (-)Ensembl
Ensembl Acc Id: ENST00000450655   ⟹   ENSP00000409825
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5132,542,066 - 132,556,838 (-)Ensembl
Ensembl Acc Id: ENST00000462418
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5132,542,066 - 132,543,920 (-)Ensembl
RefSeq Acc Id: NM_000879   ⟹   NP_000870
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,541,445 - 132,543,522 (-)NCBI
GRCh375131,877,136 - 131,892,555 (-)NCBI
Build 365131,905,035 - 131,907,113 (-)NCBI Archive
HuRef5127,069,401 - 127,071,479 (-)ENTREZGENE
CHM1_15131,310,410 - 131,312,488 (-)NCBI
T2T-CHM13v2.05133,061,254 - 133,063,331 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005271988   ⟹   XP_005272045
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,541,445 - 132,556,815 (-)NCBI
GRCh375131,877,136 - 131,892,555 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011543373   ⟹   XP_011541675
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,541,445 - 132,556,815 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047417148   ⟹   XP_047273104
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,541,445 - 132,556,815 (-)NCBI
RefSeq Acc Id: XM_054352518   ⟹   XP_054208493
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05133,061,254 - 133,076,695 (-)NCBI
RefSeq Acc Id: XM_054352519   ⟹   XP_054208494
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05133,061,254 - 133,076,695 (-)NCBI
RefSeq Acc Id: XM_054352520   ⟹   XP_054208495
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05133,061,254 - 133,076,701 (-)NCBI
RefSeq Acc Id: XM_054352521   ⟹   XP_054208496
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05133,061,254 - 133,076,701 (-)NCBI
RefSeq Acc Id: NP_000870   ⟸   NM_000879
- Peptide Label: precursor
- UniProtKB: Q13840 (UniProtKB/Swiss-Prot),   P05113 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005272045   ⟸   XM_005271988
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011541675   ⟸   XM_011543373
- Peptide Label: isoform X2
- UniProtKB: Q13840 (UniProtKB/Swiss-Prot),   P05113 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000409825   ⟸   ENST00000450655
Ensembl Acc Id: ENSP00000231454   ⟸   ENST00000231454
RefSeq Acc Id: XP_047273104   ⟸   XM_047417148
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054208496   ⟸   XM_054352521
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054208495   ⟸   XM_054352520
- Peptide Label: isoform X2
- UniProtKB: P05113 (UniProtKB/Swiss-Prot),   Q13840 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054208493   ⟸   XM_054352518
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054208494   ⟸   XM_054352519
- Peptide Label: isoform X2
- UniProtKB: P05113 (UniProtKB/Swiss-Prot),   Q13840 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05113-F1-model_v2 AlphaFold P05113 1-134 view protein structure

Promoters
RGD ID:6850130
Promoter ID:EP25044
Type:single initiation site
Name:HS_IL5
Description:Interleukin-5, Eosinophil differentiation factor/T-cell replacingfactor.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 145; Mammalian interleukin-5
Experiment Methods:Nuclease protection; Sequencing of a full-length cDNA
Regulation:T (repressed by or weakly expressed in) cells; (induced by or strongly expressed in) antigen, (induced by or strongly expressed in) mitogen
Position:
Human AssemblyChrPosition (strand)Source
Build 365131,907,113 - 131,907,173EPD
RGD ID:6870518
Promoter ID:EPDNEW_H8424
Type:multiple initiation site
Name:IL5_1
Description:interleukin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385132,543,522 - 132,543,582EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6016 AgrOrtholog
COSMIC IL5 COSMIC
Ensembl Genes ENSG00000113525 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000231454 ENTREZGENE
  ENST00000231454.6 UniProtKB/Swiss-Prot
  ENST00000450655.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000113525 GTEx
HGNC ID HGNC:6016 ENTREZGENE
Human Proteome Map IL5 Human Proteome Map
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-5_Cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3567 UniProtKB/Swiss-Prot
NCBI Gene 3567 ENTREZGENE
OMIM 147850 OMIM
PANTHER INTERLEUKIN-5 UniProtKB/Swiss-Prot
  INTERLEUKIN-5 UniProtKB/Swiss-Prot
  INTERLEUKIN-5 UniProtKB/TrEMBL
  INTERLEUKIN-5 UniProtKB/TrEMBL
Pfam IL5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29833 PharmGKB
PRINTS INTERLEUKIN5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt C9JQP9_HUMAN UniProtKB/TrEMBL
  IL5_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q13840 ENTREZGENE
UniProt Secondary Q13840 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-04-15 IL5  interleukin 5  IL5  interleukin 5 (colony-stimulating factor, eosinophil)  Symbol and/or name change 5135510 APPROVED