Il5 (interleukin 5) - Rat Genome Database

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Gene: Il5 (interleukin 5) Mus musculus
Analyze
Symbol: Il5
Name: interleukin 5
RGD ID: 10799
MGI Page MGI
Description: Enables cytokine activity. Involved in interleukin-5-mediated signaling pathway; positive regulation of immunoglobulin production; and positive regulation of transcription by RNA polymerase II. Located in extracellular space. Is expressed in colon; thymus; and thymus primordium. Human ortholog(s) of this gene implicated in asthma and stomach cancer. Orthologous to human IL5 (interleukin 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B-cell growth factor II; BCGF-II; cytotoxic T-lymphocyte inducer; eosinophil differentiation factor; Il; Il-5; interleukin-5; T-cell replacing factor; TRF
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,611,621 - 53,615,930 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,611,621 - 53,615,933 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381153,720,794 - 53,725,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,720,794 - 53,725,106 (+)Ensemblmm10GRCm38
MGSCv371153,534,296 - 53,538,605 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361153,564,217 - 53,568,526 (+)NCBIMGSCv36mm8
Celera1158,300,334 - 58,304,644 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.99NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
adult T-cell leukemia/lymphoma  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (ISO)
angiostrongyliasis  (IMP)
asthma  (IEP,IMP,ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
B-lymphoblastic leukemia/lymphoma  (IMP)
Brain Injuries  (ISO)
Bronchial Hyperreactivity  (IMP)
chronic lymphocytic leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
chronic rhinosinusitis with nasal polyps  (IEP)
Churg-Strauss syndrome  (ISO)
colitis  (IEP)
Coronavirus infectious disease  (IEP)
Cough  (ISO)
Cytomegalovirus Infections  (ISO)
echinococcosis  (IEP)
Entamoebiasis  (ISO)
Eosinophilia  (IMP,ISO)
eosinophilic esophagitis  (IMP)
eosinophilic gastroenteritis  (ISO)
esophageal cancer  (ISO)
Experimental Autoimmune Neuritis  (ISO)
extrinsic allergic alveolitis  (IEP)
food allergy  (ISO)
IgA vasculitis  (ISO)
inflammatory bowel disease  (IEP)
major depressive disorder  (ISO)
middle cerebral artery infarction  (ISO)
nephrotic syndrome  (ISO)
osteoarthritis  (ISO)
Parasitic Intestinal Diseases  (ISO)
peptic esophagitis  (ISO)
Perennial Allergic Rhinitis  (ISO)
prostatic hypertrophy  (ISO)
pulmonary eosinophilia  (IMP,ISO)
pulmonary fibrosis  (IEP,IMP,ISO)
respiratory syncytial virus infectious disease  (IMP)
rheumatoid arthritis  (ISO)
rhinitis  (IMP)
sickle cell anemia  (IEP)
status asthmaticus  (ISO)
stomach cancer  (ISO)
strongyloidiasis  (IMP)
systemic lupus erythematosus  (ISO)
Transplant Rejection  (ISO)
urinary schistosomiasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
1,1-dichloroethene  (EXP)
1,2,3,7,8-Pentachlorodibenzodioxin  (EXP)
1,4-dithiothreitol  (ISO)
1-Aminopyrene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
15-acetyldeoxynivalenol  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (EXP)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-acetyldeoxynivalenol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-nitro-m-cresol  (EXP)
5-azacytidine  (EXP)
6-anilino-5,8-quinolinedione  (EXP)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP)
9,10-phenanthroquinone  (EXP)
9-cis-retinoic acid  (ISO)
acetic acid  (EXP)
acetone  (ISO)
acetylcholine  (ISO)
acrolein  (EXP)
aflatoxin B1  (EXP,ISO)
albuterol  (ISO)
alclometasone dipropionate  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-galactosylceramide  (EXP)
aluminium hydroxide  (EXP)
aluminium sulfate (anhydrous)  (EXP)
amitrole  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
apigenin  (EXP)
aripiprazole  (ISO)
asbestos  (EXP,ISO)
ATP  (EXP)
atrazine  (EXP,ISO)
Azoxymethane  (EXP)
beclomethasone  (EXP,ISO)
benzalkonium chloride  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzofurans  (EXP)
beryllium sulfate  (EXP)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (EXP)
betamethasone valerate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bucladesine  (ISO)
budesonide  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcipotriol  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (EXP,ISO)
cetirizine  (ISO)
chloroform  (EXP)
cilostazol  (EXP)
clobenpropit  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
cortisol  (EXP,ISO)
crocidolite asbestos  (EXP)
curcumin  (EXP)
cycloheximide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cytochalasin B  (ISO)
deoxynivalenol  (EXP)
desloratadine  (ISO)
dexamethasone  (EXP,ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diisononyl phthalate  (EXP)
diisopropyl fluorophosphate  (EXP)
Dimaprit  (ISO)
dioscin  (EXP)
diuron  (ISO)
doxorubicin  (EXP)
emamectin benzoate  (ISO)
emodin  (EXP)
epinastine  (ISO)
Erionite  (EXP)
ethene  (ISO)
fenvalerate  (ISO)
ferric oxide  (EXP)
fisetin  (ISO)
flavonoids  (ISO)
flucloxacillin  (EXP)
fluorescein 5-isothiocyanate  (EXP)
flutamide  (EXP)
fluticasone  (ISO)
formaldehyde  (EXP,ISO)
fragrance  (ISO)
furfuryl alcohol  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (ISO)
glyburide  (EXP)
glyphosate  (EXP)
gossypin  (ISO)
GSK2193874  (EXP)
hexachlorobenzene  (ISO)
hexamethylene diisocyanate  (EXP)
histamine  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (ISO)
hydroxysafflor yellow A  (EXP)
hydroxytyrosol  (ISO)
IC-87114  (EXP)
ICI 118551  (ISO)
ionomycin  (EXP,ISO)
isosilybin A  (EXP)
itraconazole  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
L-1,4-dithiothreitol  (ISO)
L-arginine  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
leukotriene C4  (ISO)
leukotriene D4  (ISO)
linoleic acid  (ISO)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (EXP)
luteolin  (EXP)
melatonin  (EXP)
mercury dichloride  (EXP)
methimazole  (EXP,ISO)
methoxychlor  (EXP)
miconazole  (ISO)
mifepristone  (EXP)
Monocyte locomotion inhibitory factor  (ISO)
montelukast  (EXP,ISO)
N,N-diethyl-m-toluamide  (EXP,ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
naproxen  (ISO)
nicardipine  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
nitrososulfamethoxazole  (ISO)
Nivalenol  (EXP)
Nonylphenol  (EXP)
o-anisidine  (ISO)
ozone  (EXP,ISO)
parathion  (EXP)
pentachlorophenol  (EXP)
permethrin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phthalaldehyde  (EXP)
phthalic anhydride  (EXP,ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP)
polymyxin B2  (EXP)
pomalidomide  (ISO)
prednisolone  (EXP,ISO)
prednisone  (ISO)
prostaglandin E2  (ISO)
Pyridostigmine bromide  (EXP,ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
ribavirin  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
serpentine asbestos  (EXP)
sildenafil citrate  (EXP)
silicon dioxide  (EXP)
Silidianin  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
solasodine  (ISO)
SR 144528  (ISO)
staurosporine  (ISO)
sulfadimethoxine  (ISO)
sulfamethoxazole  (EXP)
sumatriptan  (ISO)
superoxide  (ISO)
syringin  (EXP)
T-2 toxin  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
terbinafine  (ISO)
Terfenadine  (ISO)
tetrachloromethane  (EXP,ISO)
thiazoles  (ISO)
thimerosal  (ISO)
titanium dioxide  (EXP,ISO)
tolnaftate  (ISO)
toluene  (EXP)
toluene 2,4-diisocyanate  (EXP,ISO)
tremolite asbestos  (EXP)
triadimefon  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trimellitic anhydride  (EXP)
triptonide  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
verrucarin A  (EXP)
vitamin E  (EXP,ISO)
wogonin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA,ISO)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The sickle cell mouse lung: proinflammatory and primed for allergic inflammation. Andemariam B, etal., Transl Res. 2015 Sep;166(3):254-68. doi: 10.1016/j.trsl.2015.03.001. Epub 2015 Mar 16.
2. Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. Chen J, etal., J Virol. 2010 Feb;84(3):1289-301. Epub 2009 Nov 11.
3. [Effect of Scoparone on Th1/Th2 cytokines and IgE in the experimental allergic rhinitis rats]. Cheng L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Dec;27(23):1310-2.
4. Interleukin-5 reduces the expression of uteroglobin-related protein (UGRP) 1 gene in allergic airway inflammation. Chiba Y, etal., Immunol Lett. 2005 Feb 15;97(1):123-9.
5. Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma. Cho SH, etal., Am J Respir Crit Care Med. 2005 Feb 1;171(3):224-30. Epub 2004 Oct 22.
6. A profile of immune response to herpesvirus is associated with radiographic damage in rheumatoid arthritis. Davis JM 3rd, etal., Arthritis Res Ther. 2012 Jan 31;14(1):R24.
7. Interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 in eosinophilic gastroenteritis. Desreumaux P, etal., Gastroenterology. 1996 Mar;110(3):768-74.
8. Elevated levels of serum IL-5 are associated with an increased likelihood of major depressive disorder. Elomaa AP, etal., BMC Psychiatry. 2012 Jan 9;12:2.
9. Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosis. Emad A and Emad Y, J Clin Immunol. 2008 Jul;28(4):298-305. Epub 2007 Jun 28.
10. Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis. Engel MA, etal., Dig Liver Dis. 2012 Jan;44(1):24-9. Epub 2011 Oct 22.
11. Cytokine gene expression in the skin and peripheral blood of atopic dermatitis patients and healthy individuals. Fedenko ES, etal., Self Nonself. 2011 Apr;2(2):120-124. Epub 2011 Apr 1.
12. Association of polymorphisms in the human IL4 and IL5 genes with atopic bronchial asthma and severity of the disease. Freidin MB, etal., Comp Funct Genomics. 2003;4(3):346-50.
13. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. Fuss IJ, etal., J Immunol. 1996 Aug 1;157(3):1261-70.
14. Chronic cough resembles asthma with IL-5 and granulocyte-macrophage colony-stimulating factor gene expression in bronchoalveolar cells. Gibson PG, etal., J Allergy Clin Immunol. 1998 Mar;101(3):320-6.
15. Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic mice. Glaab T, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Mar;280(3):L565-73.
16. An essential role for interleukin-5 and eosinophils in helminth-induced airway hyperresponsiveness. Hall LR, etal., Infect Immun. 1998 Sep;66(9):4425-30.
17. Anti-interleukin 5 but not anti-IgE prevents airway inflammation and airway hyperresponsiveness. Hamelmann E, etal., Am J Respir Crit Care Med. 1999 Sep;160(3):934-41.
18. IL-5 prolongs allograft survival by downregulating IL-2 and IFN-gamma cytokines. He XY, etal., Transplant Proc. 2001 Feb-Mar;33(1-2):703-4.
19. Clinical significance of serum Th1-, Th2- and regulatory T cells-associated cytokines in adult T-cell leukemia/lymphoma: high interleukin-5 and -10 levels are significant unfavorable prognostic factors. Inagaki A, etal., Int J Cancer. 2006 Jun 15;118(12):3054-61.
20. Increased production of IL-5 and dominant Th2-type response in airways of Churg-Strauss syndrome patients. Jakiela B, etal., Rheumatology (Oxford). 2012 Jul 5.
21. Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein. Johnson TR, etal., J Leukoc Biol. 2008 Sep;84(3):748-59. Epub 2008 Jun 2.
22. Interleukin-17-mediated immunopathogenesis in experimental hypersensitivity pneumonitis. Joshi AD, etal., Am J Respir Crit Care Med. 2009 Apr 15;179(8):705-16. Epub 2009 Jan 16.
23. Resveratrol prevents development of eosinophilic rhinosinusitis with nasal polyps in a mouse model. Kim SW, etal., Allergy. 2013 Jul;68(7):862-9. doi: 10.1111/all.12132. Epub 2013 Jun 10.
24. Interleukin-5 expression in the lung epithelium of transgenic mice leads to pulmonary changes pathognomonic of asthma. Lee JJ, etal., J Exp Med. 1997 Jun 16;185(12):2143-56.
25. Tiarellic acid attenuates airway hyperresponsiveness and inflammation in a murine model of allergic asthma. Lee MY, etal., Int Immunopharmacol. 2012 Jan;12(1):117-24. Epub 2011 Nov 12.
26. [Serum levels of IL-5 and LTB4 in children with Henoch-Schonlein purpura]. Liao PY and Wu SH, Zhongguo Dang Dai Er Ke Za Zhi. 2006 Jun;8(3):198-200.
27. [The roles of interleukin-5 and eotaxin in signal transmission between lung and bone marrow of rat asthmatic models] Liu CT, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Aug;29(8):558-62.
28. [Effects of suplatast tosilate on airway inflammation and interleukin-5 in asthmatic rats]. Liu D, etal., Zhongguo Dang Dai Er Ke Za Zhi. 2014 Jul;16(7):759-63.
29. Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population. Mahajan R, etal., Jpn J Clin Oncol. 2008 Sep;38(9):626-33. doi: 10.1093/jjco/hyn075. Epub 2008 Aug 7.
30. Spirometric parameters and levels of interferon gamma and IL-5 in induced sputum from patients with allergic rhinitis or asthma. Marra SM, etal., Am J Rhinol Allergy. 2011 Sep-Oct;25(5):e196-9.
31. T-cell activation genes differentially expressed at birth in CD4(+) T-cells from children who develop IgE food allergy. Martino DJ, etal., Allergy. 2012 Feb;67(2):191-200. doi: 10.1111/j.1398-9995.2011.02737.x. Epub 2011 Nov 11.
32. Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis. Masterson JC, etal., Gut. 2014 Jan;63(1):43-53. doi: 10.1136/gutjnl-2012-303631. Epub 2012 Nov 17.
33. Increased interleukin-4 and interleukin-5 production in response to Schistosoma haematobium adult worm antigens correlates with lack of reinfection after treatment. Medhat A, etal., J Infect Dis. 1998 Aug;178(2):512-9.
34. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
35. MGDs mouse GO annotations MGD data from the GO Consortium
36. MGD IEA MGD IEA
37. Early peritoneal immune response during Echinococcus granulosus establishment displays a biphasic behavior. Mourglia-Ettlin G, etal., PLoS Negl Trop Dis. 2011 Aug;5(8):e1293. doi: 10.1371/journal.pntd.0001293. Epub 2011 Aug 30.
38. Increased vascular endothelial growth factor in acute eosinophilic pneumonia. Nishigaki Y, etal., Eur Respir J. 2003 May;21(5):774-8.
39. [An investigation of the clinical utility of serum interleukin-5 measurements in bronchial asthma patients]. Onizuka R, etal., Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Nov;35(11):1215-22.
40. Regulation of primary Strongyloides ratti infections in mice: a role for interleukin-5. Ovington KS, etal., Immunology. 1998 Nov;95(3):488-93.
41. Expression profiles of Th17 pathway related genes in human systemic lupus erythematosus. Pan HF, etal., Mol Biol Rep. 2013 Jan;40(1):391-9. doi: 10.1007/s11033-012-2073-2. Epub 2012 Oct 9.
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
44. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
45. Mouse MP Annotation Import Pipeline RGD automated import pipeline
46. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
47. LHRH antagonist Cetrorelix reduces prostate size and gene expression of proinflammatory cytokines and growth factors in a rat model of benign prostatic hyperplasia. Rick FG, etal., Prostate. 2011 May 15;71(7):736-47. doi: 10.1002/pros.21289. Epub 2010 Oct 13.
48. Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke. Ruscher K, etal., PLoS One. 2012;7(9):e45118. doi: 10.1371/journal.pone.0045118. Epub 2012 Sep 18.
49. Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiency. Saito H, etal., J Immunol. 2002 Mar 15;168(6):3017-23.
50. Ablation of eosinophils with anti-IL-5 antibody enhances the survival of intracranial worms of Angiostrongylus cantonensis in the mouse. Sasaki O, etal., Parasite Immunol. 1993 Jun;15(6):349-54.
51. Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats. Stoner GD, etal., Pharm Res. 2010 Jun;27(6):1138-45. Epub 2010 Mar 16.
52. Taurine improves functional and histological outcomes and reduces inflammation in traumatic brain injury. Su Y, etal., Neuroscience. 2014 Apr 25;266:56-65. doi: 10.1016/j.neuroscience.2014.02.006. Epub 2014 Feb 14.
53. Dual proinflammatory and antiviral properties of pulmonary eosinophils in respiratory syncytial virus vaccine-enhanced disease. Su YC, etal., J Virol. 2015 Feb;89(3):1564-78. doi: 10.1128/JVI.01536-14. Epub 2014 Nov 19.
54. A novel rat model to determine interaction between reflux oesophagitis and bronchial asthma. Sugawa T, etal., Gut. 2008 May;57(5):575-81. Epub 2008 Jan 25.
55. Preventive effect of hochu-ekki-to, a Japanese herbal medicine, on bleomycin-induced lung injury in mice. Tajima S, etal., Respirology. 2007 Nov;12(6):814-22.
56. Suppressed cytokine expression immediatey following traumatic brain injury in neonatal rats indicates an expeditious endogenous anti-inflammatory response. Tajiri N, etal., Brain Res. 2014 Apr 22;1559:65-71. doi: 10.1016/j.brainres.2014.02.041. Epub 2014 Mar 3.
57. Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice. Tanaka H, etal., Am J Respir Cell Mol Biol. 2004 Jul;31(1):62-8. Epub 2004 Feb 19.
58. TARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas. Thielen C, etal., Leuk Res. 2008 Sep;32(9):1431-8. doi: 10.1016/j.leukres.2008.02.016. Epub 2008 Apr 18.
59. CC chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus. Potential implication in eosinophil recruitment. Tillie-Leblond I, etal., Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):586-92.
60. Transgenic mice expressing a B cell growth and differentiation factor gene (interleukin 5) develop eosinophilia and autoantibody production. Tominaga A, etal., J Exp Med. 1991 Feb 1;173(2):429-37.
61. IL-5 promotes induction of antigen-specific CD4+CD25+ T regulatory cells that suppress autoimmunity. Tran GT, etal., Blood. 2012 May 10;119(19):4441-50. doi: 10.1182/blood-2011-12-396101. Epub 2012 Feb 6.
62. The differences of eosinophil- and neutrophil-related inflammation in elderly allergic and non-allergic chronic obstructive pulmonary disease. Tsai JJ, etal., J Asthma. 2010 Nov;47(9):1040-4.
63. Expression of leukotriene biosynthetic enzymes in tonsillar tissue of children with obstructive sleep apnea: a prospective nonrandomized study. Tsaoussoglou M, etal., JAMA Otolaryngol Head Neck Surg. 2014 Oct;140(10):944-50. doi: 10.1001/jamaoto.2014.1936.
64. Interleukin (IL) 5 levels and eosinophilia in patients with intestinal parasitic diseases. Ustun S, etal., World J Gastroenterol. 2004 Dec 15;10(24):3643-6.
65. Human knee synovial fluid cytokines correlated with grade of knee osteoarthritis--a pilot study. Vangsness CT Jr, etal., Bull NYU Hosp Jt Dis. 2011;69(2):122-7.
66. Knockdown of neurokinin-1 receptor expression by small interfering RNA prevents the development of allergic rhinitis in rats. Wang H, etal., Inflamm Res. 2013 Oct;62(10):903-10. doi: 10.1007/s00011-013-0649-5. Epub 2013 Aug 11.
67. Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus. Wen X, etal., Eur J Immunol. 2004 Oct;34(10):2740-9.
68. In vivo changes of hemopoietic progenitors and the expression of the interleukin 5 gene in eosinophilic mice infected with Toxocara canis. Yamaguchi Y, etal., Exp Hematol. 1990 Dec;18(11):1152-7.
69. Heterogeneity of interleukin 5 genetic background in atopic dermatitis patients: significant difference between those with blood eosinophilia and normal eosinophil levels. Yamamoto N, etal., J Dermatol Sci. 2003 Nov;33(2):121-6.
70. Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia. Yan XJ, etal., Blood. 2011 Nov 10;118(19):5201-10. doi: 10.1182/blood-2011-03-342436. Epub 2011 Sep 12.
71. The clinical characteristics of steroid responsive nephrotic syndrome of children according to the serum immunoglobulin E levels and cytokines. Youn YS, etal., Yonsei Med J. 2012 Jul 1;53(4):715-22. doi: 10.3349/ymj.2012.53.4.715.
72. Effects of antisense interleukin-5 gene transferred by recombinant adeno-associated virus to allergic rats. Zeng D, etal., Respirology. 2010 Jan;15(1):132-40. Epub 2009 Nov 30.
Additional References at PubMed
PMID:1347470   PMID:1349581   PMID:1353738   PMID:1358285   PMID:1649220   PMID:1794054   PMID:1794058   PMID:1969921   PMID:2215480   PMID:2230651   PMID:2466396   PMID:2563351  
PMID:2784565   PMID:2784591   PMID:2789124   PMID:2823259   PMID:3024009   PMID:3024129   PMID:3078564   PMID:3133208   PMID:7507352   PMID:7541729   PMID:7543541   PMID:7615560  
PMID:7749983   PMID:7774561   PMID:7841363   PMID:7950399   PMID:7974717   PMID:8012110   PMID:8100556   PMID:8204886   PMID:8207122   PMID:8223866   PMID:8227050   PMID:8245456  
PMID:8258700   PMID:8313907   PMID:8406478   PMID:8461254   PMID:8499630   PMID:8524855   PMID:8551213   PMID:8551223   PMID:8557976   PMID:8574848   PMID:8595891   PMID:8618887  
PMID:8770556   PMID:8875898   PMID:8918267   PMID:8934515   PMID:8988371   PMID:8992981   PMID:9013977   PMID:9070927   PMID:9098436   PMID:9105679   PMID:9177770   PMID:9243294  
PMID:9294206   PMID:9344502   PMID:9498782   PMID:9500796   PMID:9551990   PMID:9686617   PMID:9739047   PMID:9741339   PMID:9858522   PMID:9916727   PMID:9973388   PMID:10072551  
PMID:10207161   PMID:10224281   PMID:10229862   PMID:10338513   PMID:10444455   PMID:10452966   PMID:10456878   PMID:10558953   PMID:10570267   PMID:10623847   PMID:10655497   PMID:10663563  
PMID:10671193   PMID:10704283   PMID:10725799   PMID:10841566   PMID:10872802   PMID:10898511   PMID:10970823   PMID:11012974   PMID:11031101   PMID:11035095   PMID:11037973   PMID:11057672  
PMID:11058459   PMID:11160193   PMID:11306598   PMID:11440633   PMID:11544284   PMID:11590387   PMID:11694459   PMID:11733500   PMID:11830476   PMID:11859139   PMID:11960640   PMID:12045241  
PMID:12083417   PMID:12097386   PMID:12150887   PMID:12231478   PMID:12466851   PMID:12477932   PMID:12507769   PMID:12620930   PMID:12648490   PMID:12660425   PMID:14514727   PMID:14565926  
PMID:14598258   PMID:14607953   PMID:14635046   PMID:14638787   PMID:14966564   PMID:14969690   PMID:15087456   PMID:15100311   PMID:15128785   PMID:15162425   PMID:15214040   PMID:15240714  
PMID:15277569   PMID:15286809   PMID:15322148   PMID:15388256   PMID:15470039   PMID:15514019   PMID:15563687   PMID:15589174   PMID:15593125   PMID:15632004   PMID:15661899   PMID:15662016  
PMID:15823208   PMID:15880101   PMID:15944318   PMID:15963784   PMID:16275384   PMID:16339565   PMID:16495517   PMID:16606668   PMID:16751370   PMID:16769892   PMID:16783848   PMID:16849489  
PMID:16856933   PMID:16909433   PMID:17015719   PMID:17035062   PMID:17101709   PMID:17177681   PMID:17371978   PMID:17487773   PMID:17579048   PMID:17601518   PMID:17623648   PMID:17627772  
PMID:17883722   PMID:17934471   PMID:18166354   PMID:18268038   PMID:18390753   PMID:18410989   PMID:18490710   PMID:18768855   PMID:18772129   PMID:18829681   PMID:18839016   PMID:18997793  
PMID:19198019   PMID:19224206   PMID:19282460   PMID:19548628   PMID:19650867   PMID:19734227   PMID:19954023   PMID:20107184   PMID:20337994   PMID:20412815   PMID:20494340   PMID:20693421  
PMID:20876456   PMID:20976099   PMID:21037078   PMID:21267068   PMID:21276008   PMID:21402950   PMID:21460847   PMID:21646791   PMID:22048766   PMID:22174445   PMID:22348321   PMID:22424785  
PMID:22459292   PMID:22539286   PMID:22627364   PMID:22633287   PMID:23150660   PMID:23420878   PMID:23554941   PMID:23711860   PMID:23755285   PMID:23810766   PMID:23855447   PMID:23942524  
PMID:24037376   PMID:24068930   PMID:24115031   PMID:24246030   PMID:24478083   PMID:24605680   PMID:24631157   PMID:24663677   PMID:24738290   PMID:24808371   PMID:25015831   PMID:25092334  
PMID:25323825   PMID:25409540   PMID:25452118   PMID:25629516   PMID:25691457   PMID:26092469   PMID:26129648   PMID:26425820   PMID:26675736   PMID:26719095   PMID:27453471   PMID:27683753  
PMID:27742702   PMID:27749840   PMID:28096407   PMID:28228256   PMID:28302646   PMID:28317868   PMID:28405615   PMID:28431248   PMID:28506464   PMID:28589929   PMID:28725048   PMID:28737771  
PMID:28921511   PMID:28935682   PMID:28982732   PMID:29122948   PMID:29133293   PMID:29758105   PMID:29887373   PMID:30201992   PMID:30446384   PMID:30575775   PMID:30755607   PMID:30824323  
PMID:30853691   PMID:30980570   PMID:31109364   PMID:31128962   PMID:31328158   PMID:31469835   PMID:31674692   PMID:32031571   PMID:32240600   PMID:32268121   PMID:32444388   PMID:32552827  
PMID:32948777   PMID:33002412   PMID:33393815   PMID:33494375   PMID:33536623   PMID:33852849   PMID:33917349   PMID:34259869   PMID:34290377   PMID:34428519   PMID:34473956   PMID:34506849  
PMID:34707292   PMID:34974065   PMID:35042776   PMID:35075279   PMID:35139352   PMID:35245089   PMID:35303432   PMID:35443177   PMID:35468400   PMID:36044899   PMID:36071169   PMID:36323781  
PMID:36323785   PMID:36411381   PMID:36525971   PMID:36571761   PMID:36592421   PMID:36693372   PMID:36720287   PMID:36750100   PMID:36811605   PMID:37036426   PMID:37676935   PMID:37833706  
PMID:37921466   PMID:38030609   PMID:38597952   PMID:38670109   PMID:38723629   PMID:38772366   PMID:38776917   PMID:38938056   PMID:38963241   PMID:39028828   PMID:39141517   PMID:39366382  
PMID:39632879   PMID:39909036   PMID:40074948  


Genomics

Comparative Map Data
Il5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,611,621 - 53,615,930 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,611,621 - 53,615,933 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381153,720,794 - 53,725,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,720,794 - 53,725,106 (+)Ensemblmm10GRCm38
MGSCv371153,534,296 - 53,538,605 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361153,564,217 - 53,568,526 (+)NCBIMGSCv36mm8
Celera1158,300,334 - 58,304,644 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.99NCBI
IL5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,541,445 - 132,556,815 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5132,541,445 - 132,556,838 (-)Ensemblhg38GRCh38
GRCh375131,877,137 - 131,879,214 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,905,035 - 131,907,113 (-)NCBIBuild 36Build 36hg18NCBI36
Build 345131,905,034 - 131,907,113NCBI
Celera5128,007,258 - 128,009,336 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,069,401 - 127,071,479 (-)NCBIHuRef
CHM1_15131,310,410 - 131,312,488 (-)NCBICHM1_1
T2T-CHM13v2.05133,061,254 - 133,076,701 (-)NCBIT2T-CHM13v2.0
Il5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81038,375,132 - 38,378,003 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1038,375,132 - 38,378,003 (+)EnsemblGRCr8
mRatBN7.21037,874,342 - 37,877,213 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1037,874,342 - 37,877,213 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1042,566,241 - 42,569,117 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01042,056,311 - 42,059,187 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01037,560,033 - 37,562,909 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01039,066,716 - 39,069,587 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,066,716 - 39,069,587 (+)Ensemblrn6Rnor6.0
Rnor_5.01038,848,654 - 38,851,525 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41039,177,786 - 39,180,657 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1037,217,913 - 37,220,782 (+)NCBICelera
RGSC_v3.11039,187,032 - 39,189,904 (+)NCBI
RH 3.4 Map10405.8RGD
Cytogenetic Map10q22NCBI
Il5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554083,937,894 - 3,939,358 (-)Ensembl
ChiLan1.0NW_0049554083,937,128 - 3,951,784 (-)NCBIChiLan1.0ChiLan1.0
IL5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24127,852,984 - 127,868,373 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15125,985,380 - 126,007,938 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05127,955,377 - 127,961,726 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,119,608 - 134,121,682 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,119,608 - 134,121,675 (-)EnsemblpanPan2panpan1.1
IL5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,825,469 - 20,827,269 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,825,469 - 20,827,269 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1119,627,141 - 19,628,942 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01121,611,416 - 21,613,216 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1121,611,416 - 21,613,216 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,329,893 - 20,331,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,177,516 - 20,179,316 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,819,966 - 20,821,765 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Il5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213115,645,479 - 115,648,668 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366472,648,241 - 2,651,430 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366472,647,982 - 2,651,477 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2134,832,147 - 134,835,212 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.12134,832,143 - 134,846,141 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22140,301,702 - 140,315,329 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12335,360,143 - 35,375,169 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2335,360,506 - 35,362,178 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603442,568,292 - 42,583,307 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473339,556,797 - 39,559,119 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473339,544,487 - 39,558,943 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Il5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1936,201,293 - 36,204,023 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Il5
176 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:388
Count of miRNA genes:296
Interacting mature miRNAs:329
Transcripts:ENSMUST00000048605
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
4141770Tcpm1_mT-cell phenotype modifier 1 (mouse)Not determined5145247953615930Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse

Markers in Region
D618  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381153,722,793 - 53,723,008UniSTSGRCm38
MGSCv371153,536,295 - 53,536,510UniSTSGRCm37
Celera1158,302,334 - 58,302,549UniSTS
Cytogenetic Map11A5UniSTS
Whitehead_YAC11 UniSTS
X06271  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381153,724,332 - 53,724,513UniSTSGRCm38
MGSCv371153,537,834 - 53,538,015UniSTSGRCm37
Celera1158,303,873 - 58,304,054UniSTS
Cytogenetic Map11A5UniSTS
Whitehead/MRC_RH11727.12UniSTS
Whitehead_YAC11 UniSTS
Il5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371153,534,876 - 53,535,168UniSTSGRCm37
MGSCv371153,539,203 - 53,539,283UniSTSGRCm37
Celera1158,305,242 - 58,305,322UniSTS
Celera1158,300,914 - 58,301,206UniSTS
Cytogenetic Map11A5UniSTS
cM Map1129.2UniSTS
cM Map1129.2UniSTS
cM Map1129.2UniSTS
cM Map11 UniSTS
cM Map1129.2UniSTS
D11Nds9  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381153,722,738 - 53,723,028UniSTSGRCm38
MGSCv371153,536,240 - 53,536,530UniSTSGRCm37
Celera1158,302,279 - 58,302,569UniSTS
Cytogenetic Map11A5UniSTS
cM Map1127.95UniSTS
cM Map1129.2UniSTS
Il5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A5UniSTS
cM Map1129.2UniSTS
Il5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A5UniSTS
cM Map1129.2UniSTS
Il5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381153,721,374 - 53,721,666UniSTSGRCm38
MGSCv371153,534,876 - 53,535,168UniSTSGRCm37
Celera1158,300,914 - 58,301,206UniSTS
Cytogenetic Map11A5UniSTS
cM Map1129.2UniSTS
Il5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A5UniSTS
cM Map1129.2UniSTS
cM Map11 UniSTS
X06271  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381153,724,893 - 53,724,986UniSTSGRCm38
MGSCv371153,538,395 - 53,538,488UniSTSGRCm37
Celera1158,304,434 - 58,304,527UniSTS
Cytogenetic Map11A5UniSTS
Whitehead/MRC_RH11727.12UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000048605   ⟹   ENSMUSP00000043369
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1153,611,621 - 53,615,933 (+)Ensembl
GRCm38.p6 Ensembl1153,720,794 - 53,725,106 (+)Ensembl
RefSeq Acc Id: NM_010558   ⟹   NP_034688
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391153,611,621 - 53,615,930 (+)NCBI
GRCm381153,720,794 - 53,725,103 (+)NCBI
MGSCv371153,534,296 - 53,538,605 (+)RGD
Celera1158,300,334 - 58,304,644 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034688   ⟸   NM_010558
- Peptide Label: precursor
- UniProtKB: P04401 (UniProtKB/Swiss-Prot),   Q5SV01 (UniProtKB/TrEMBL),   Q05A89 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000043369   ⟸   ENSMUST00000048605

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04401-F1-model_v2 AlphaFold P04401 1-133 view protein structure

Promoters
RGD ID:6850128
Promoter ID:EP25045
Type:single initiation site
Name:MM_IL5
Description:Interleukin-5, Eosinophil differentiation factor/T-cell replacingfactor, IL5 or IL-5 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 145; Mammalian interleukin-5
Experiment Methods:Sequencing of a full-length cDNA
Regulation:T (repressed by or weakly expressed in) cells; (induced by or strongly expressed in) antigen, (induced by or strongly expressed in) mitogen
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv371153,534,296 - 53,534,356EPD
MGSCv361153,534,296 - 53,534,356EPD
RGD ID:6821110
Promoter ID:MM_KWN:7400
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:OTTMUST00000012554
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361153,534,496 - 53,534,996 (+)MPROMDB
RGD ID:8674624
Promoter ID:EPDNEW_M15343
Type:multiple initiation site
Name:Il5_1
Description:Mus musculus interleukin 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381153,720,793 - 53,720,853EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96557 AgrOrtholog
Ensembl Genes ENSMUSG00000036117 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000048605 ENTREZGENE
  ENSMUST00000048605.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-5 UniProtKB/Swiss-Prot
KEGG Report mmu:16191 UniProtKB/Swiss-Prot
MGD MGI:96557 ENTREZGENE
NCBI Gene 16191 ENTREZGENE
PANTHER INTERLEUKIN-5 UniProtKB/Swiss-Prot
  INTERLEUKIN-5 UniProtKB/Swiss-Prot
Pfam IL5 UniProtKB/Swiss-Prot
PhenoGen Il5 PhenoGen
PRINTS INTERLEUKIN5 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt IL5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q05A89 ENTREZGENE
  Q5SV01 ENTREZGENE, UniProtKB/TrEMBL
  Q62349_MOUSE UniProtKB/TrEMBL